SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yfg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 8 VAL B 122
ARG B  75
ALA B  48
GLU B 100
 None
 1.01A 1dmiA-4yfgB:
undetectable
1dmiB-4yfgB:
undetectable		 1dmiA-4yfgB:
22.53
1dmiB-4yfgB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 7 PHE B 235
ALA B 310
ILE B 252
PRO B 239
 None
 0.89A 1oniA-4yfgB:
undetectable
1oniB-4yfgB:
undetectable		 1oniA-4yfgB:
15.14
1oniB-4yfgB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 6 PHE B 235
ALA B 310
ILE B 252
PRO B 239
 None
 1.02A 1oniH-4yfgB:
undetectable
1oniI-4yfgB:
undetectable		 1oniH-4yfgB:
15.14
1oniI-4yfgB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		3 / 3 THR B  29
PRO B  58
PRO B  30
 None
 0.82A 2d55C-4yfgB:
undetectable		 2d55C-4yfgB:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		3 / 3 GLN B 412
THR B 493
ASN B 442
 None
 0.73A 3v4tE-4yfgB:
undetectable		 3v4tE-4yfgB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		4 / 8 SER B 198
ARG B 181
GLY B 204
GLN B 203
 None
 1.02A 4af0A-4yfgB:
undetectable		 4af0A-4yfgB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		3 / 3 SER B 349
ALA B 392
VAL B 391
 None
 0.57A 4o2bA-4yfgB:
undetectable		 4o2bA-4yfgB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		3 / 3 SER B 349
ALA B 392
VAL B 391
 None
 0.56A 4x1iA-4yfgB:
undetectable		 4x1iA-4yfgB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		5 / 11 VAL B 209
PHE B 132
GLY B  46
GLY B  45
ILE B  91
 None
 1.36A 4zvmA-4yfgB:
undetectable
4zvmB-4yfgB:
undetectable		 4zvmA-4yfgB:
18.87
4zvmB-4yfgB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		3 / 3 SER B 349
ALA B 392
VAL B 391
 None
 0.58A 5eypA-4yfgB:
undetectable		 5eypA-4yfgB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Mus
musculus) 		5 / 12 TYR B 386
ALA B 333
SER B 376
HIS B 355
PHE B 388
 None
 1.40A 5wbvA-4yfgB:
undetectable		 5wbvA-4yfgB:
19.83