SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4yfh DNA-BINDING PROTEIN
HU-ALPHA
(Escherichia
coli) 		5 / 12 ILE A  32
ALA A  31
ALA A  24
ILE A  10
PHE A  50
 None
 1.08A 2h77A-4yfhA:
undetectable		 2h77A-4yfhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4yfh DNA-BINDING PROTEIN
HU-ALPHA
(Escherichia
coli) 		4 / 6 ASN A  75
HIS A  54
PRO A  77
ASP A  40
 None
 1.19A 3oi8A-4yfhA:
undetectable		 3oi8A-4yfhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4yfh DNA-BINDING PROTEIN
HU-ALPHA
(Escherichia
coli) 		5 / 12 ILE A  32
ALA A  31
ALA A  24
ILE A  10
PHE A  50
 None
 1.02A 4lnwA-4yfhA:
undetectable		 4lnwA-4yfhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4yfh DNA-BINDING PROTEIN
HU-ALPHA
(Escherichia
coli) 		5 / 12 ILE A  32
ALA A  31
ALA A  24
ILE A  10
PHE A  50
 None
 1.03A 4lnxA-4yfhA:
undetectable		 4lnxA-4yfhA:
15.09