SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 111
LEU A  45
LEU A  43
ILE A  31
LEU A 125
 None
 1.46A 1ereC-4yfjA:
undetectable		 1ereC-4yfjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 111
LEU A  45
LEU A  43
ILE A  31
LEU A 125
 None
 1.45A 1ereD-4yfjA:
undetectable		 1ereD-4yfjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  29
VAL A  42
LEU A  43
ALA A  77
 None
 0.79A 1pthA-4yfjA:
undetectable		 1pthA-4yfjA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  29
VAL A  42
LEU A  43
ALA A  77
 None
 0.79A 1pthB-4yfjA:
undetectable		 1pthB-4yfjA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 112
ILE A  26
GLY A 120
ILE A 126
LEU A 110
 SO4  A 204 ( 4.5A)
None
SO4  A 201 (-3.1A)
None
SO4  A 204 (-4.4A)
 1.13A 1z11C-4yfjA:
undetectable		 1z11C-4yfjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 110
ALA A  91
GLY A  88
ILE A 107
LEU A 129
 SO4  A 204 (-4.4A)
None
None
None
None
 1.27A 3gyqA-4yfjA:
undetectable
3gyqB-4yfjA:
undetectable		 3gyqA-4yfjA:
24.35
3gyqB-4yfjA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 128
ARG A 131
GLU A 135
 None
 1.19A 3qf1A-4yfjA:
undetectable		 3qf1A-4yfjA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 109
PRO A 151
TYR A 156
LEU A 155
 None
SO4  A 204 ( 4.6A)
None
SO4  A 201 ( 4.4A)
 1.05A 5bmvB-4yfjA:
undetectable		 5bmvB-4yfjA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 142
LEU A 129
ALA A 133
LEU A 136
TYR A  93
 None
 1.29A 5ljcA-4yfjA:
undetectable		 5ljcA-4yfjA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 129
LYS A 130
ALA A 133
LEU A 136
 None
 0.87A 5vkqC-4yfjA:
undetectable
5vkqD-4yfjA:
undetectable		 5vkqC-4yfjA:
7.21
5vkqD-4yfjA:
7.21