SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yfl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yfl 1B2530 HEAVY CHAIN
1B2530 LIGHT CHAIN
(Homo
sapiens) 		5 / 12 SER L 175
TYR L 177
PHE H 178
SER L 165
VAL H 164
 None
 1.44A 1q23D-4yflL:
undetectable
1q23E-4yflL:
undetectable		 1q23D-4yflL:
21.81
1q23E-4yflL:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4yfl 1B2530 LIGHT CHAIN
(Homo
sapiens) 		4 / 5 TYR L  91
TYR L  32
ARG L  96
GLY L  95
 None
 1.24A 1ve9A-4yflL:
undetectable		 1ve9A-4yflL:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4yfl 1B2530 LIGHT CHAIN
(Homo
sapiens) 		4 / 5 TYR L  91
TYR L  32
ARG L  96
GLY L  95
 None
 1.15A 2du8J-4yflL:
undetectable		 2du8J-4yflL:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4yfl 1B2530 LIGHT CHAIN
(Homo
sapiens) 		5 / 12 GLY L 101
GLY L  99
LEU L  46
LEU L  47
LEU L  73
 None
 0.77A 2egvA-4yflL:
undetectable		 2egvA-4yflL:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4yfl 1B2530 HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H 189
VAL H 181
SER H 191
VAL H 154
 None
 1.34A 2j9cA-4yflH:
undetectable
2j9cB-4yflH:
undetectable
2j9cC-4yflH:
undetectable		 2j9cA-4yflH:
13.91
2j9cB-4yflH:
13.91
2j9cC-4yflH:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yfl 1B2530 HEAVY CHAIN
1B2530 LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 10 SER L 175
TYR L 177
PHE H 178
SER L 165
VAL H 164
 None
 1.38A 3u9fI-4yflL:
undetectable		 3u9fI-4yflL:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yfl 1B2530 HEAVY CHAIN
1B2530 LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 10 SER L 175
TYR L 177
PHE H 178
SER L 165
VAL H 164
 None
 1.47A 3u9fR-4yflL:
undetectable		 3u9fR-4yflL:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4yfl 1B2530 HEAVY CHAIN
(Homo
sapiens) 		4 / 7 TYR H  54
GLY H  56
ILE H  51
ILE H  33
 None
 0.66A 4eatA-4yflH:
undetectable		 4eatA-4yflH:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4yfl 1B2530 HEAVY CHAIN
1B2530 LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE H 112
ASP H 113
PRO L  44
ILE H  33
 None
 0.74A 4pcuA-4yflH:
undetectable		 4pcuA-4yflH:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 4yfl 1B2530 HEAVY CHAIN
1B2530 LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 VAL H 181
TYR H 188
GLU L 160
 None
 0.93A 5zmqD-4yflH:
undetectable
5zmqE-4yflH:
undetectable		 5zmqD-4yflH:
21.55
5zmqE-4yflH:
12.95