SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.12A 1c9sN-4yfmA:
undetectable
1c9sO-4yfmA:
undetectable		 1c9sN-4yfmA:
15.00
1c9sO-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 11 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.13A 1c9sP-4yfmA:
undetectable
1c9sQ-4yfmA:
undetectable		 1c9sP-4yfmA:
15.00
1c9sQ-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.11A 1c9sQ-4yfmA:
undetectable
1c9sR-4yfmA:
undetectable		 1c9sQ-4yfmA:
15.00
1c9sR-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.13A 1c9sL-4yfmA:
undetectable
1c9sV-4yfmA:
undetectable		 1c9sL-4yfmA:
15.00
1c9sV-4yfmA:
15.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		6 / 12 SER A  71
LYS A  74
SER A 131
ASN A 133
LYS A 233
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
 0.28A 1ghmA-4yfmA:
36.3		 1ghmA-4yfmA:
32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.08A 1gtfD-4yfmA:
undetectable
1gtfE-4yfmA:
undetectable		 1gtfD-4yfmA:
15.00
1gtfE-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.09A 1gtfJ-4yfmA:
undetectable
1gtfK-4yfmA:
undetectable		 1gtfJ-4yfmA:
15.00
1gtfK-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 11 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.15A 1gtfQ-4yfmA:
undetectable
1gtfR-4yfmA:
undetectable		 1gtfQ-4yfmA:
15.00
1gtfR-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.17A 1gtfR-4yfmA:
undetectable
1gtfS-4yfmA:
undetectable		 1gtfR-4yfmA:
15.00
1gtfS-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 11 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.15A 1gtfS-4yfmA:
undetectable
1gtfT-4yfmA:
undetectable		 1gtfS-4yfmA:
15.00
1gtfT-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 11 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.15A 1gtnT-4yfmA:
undetectable
1gtnU-4yfmA:
undetectable		 1gtnT-4yfmA:
15.00
1gtnU-4yfmA:
15.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 SER A  71
LYS A  74
SER A 131
ASN A 133
GLU A 167
THR A 215
LYS A 233
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
 0.42A 1i2wA-4yfmA:
40.1		 1i2wA-4yfmA:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 SER A  71
LYS A  74
SER A 131
ASN A 133
GLU A 167
THR A 215
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.3A)
 0.43A 1i2wB-4yfmA:
40.2		 1i2wB-4yfmA:
44.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 12 ALA A  50
ILE A 248
ILE A 220
ILE A 282
ALA A 289
 None
 1.00A 1sguB-4yfmA:
undetectable		 1sguB-4yfmA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.10A 1utdE-4yfmA:
undetectable
1utdF-4yfmA:
undetectable		 1utdE-4yfmA:
15.00
1utdF-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.09A 1utdH-4yfmA:
undetectable
1utdI-4yfmA:
undetectable		 1utdH-4yfmA:
15.00
1utdI-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A 272
ALA A 279
THR A 262
ILE A 276
GLY A  44
 None
 1.16A 1utdU-4yfmA:
undetectable
1utdV-4yfmA:
undetectable		 1utdU-4yfmA:
15.00
1utdV-4yfmA:
15.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		10 / 12 SER A  71
LYS A  74
SER A 131
ASN A 133
GLU A 167
ASN A 171
THR A 215
LYS A 233
GLY A 235
GLY A 237
 ACT  A 301 (-3.5A)
ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.56A 1ymxA-4yfmA:
42.0		 1ymxA-4yfmA:
44.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		9 / 12 SER A  71
LYS A  74
SER A 131
ASN A 133
GLU A 167
ASN A 171
LYS A 233
GLY A 235
GLY A 237
 ACT  A 301 (-3.5A)
ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.50A 1ymxB-4yfmA:
42.3		 1ymxB-4yfmA:
44.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		4 / 5 LEU A  51
VAL A  78
LEU A  82
ARG A 212
 None
 1.10A 2oiqA-4yfmA:
undetectable		 2oiqA-4yfmA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		4 / 4 VAL A  48
ARG A 281
ILE A 248
THR A 262
 None
 1.00A 3cl9A-4yfmA:
undetectable		 3cl9A-4yfmA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 LYS A  74
SER A 131
ASN A 133
ASN A 171
THR A 215
LYS A 233
GLY A 235
GLY A 237
 ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.46A 3hlwA-4yfmA:
41.9		 3hlwA-4yfmA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 SER A 131
ASN A 133
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.41A 3hlwB-4yfmA:
42.2		 3hlwB-4yfmA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 CYH A  70
LYS A  74
ASN A 133
ASN A 171
LYS A 233
THR A 234
GLY A 235
GLY A 237
 None
ACT  A 301 ( 4.8A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.34A 3huoA-4yfmA:
42.0		 3huoA-4yfmA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 6 THR A  53
ARG A 190
LEU A 194
ALA A 254
PRO A 255
 None
 0.43A 3huoA-4yfmA:
42.0		 3huoA-4yfmA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 CYH A  70
LYS A  74
ASN A 133
ASN A 171
LYS A 233
GLY A 235
GLY A 237
 None
ACT  A 301 ( 4.8A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.34A 3huoB-4yfmA:
42.2		 3huoB-4yfmA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.44A 3ny4A-4yfmA:
39.4		 3ny4A-4yfmA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 LYS A  74
SER A 131
ASN A 133
ASN A 171
LYS A 233
GLY A 235
GLY A 237
 ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.34A 3q07A-4yfmA:
41.9		 3q07A-4yfmA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 LYS A  74
SER A 131
ASN A 133
ASN A 171
LYS A 233
GLY A 235
GLY A 237
 ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.41A 3q07B-4yfmA:
39.4		 3q07B-4yfmA:
43.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		3 / 3 THR A 181
ASP A 158
GLU A 150
 None
 0.79A 3qowA-4yfmA:
undetectable		 3qowA-4yfmA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		6 / 12 SER A  71
SER A 131
ASN A 133
LYS A 233
THR A 234
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
 0.18A 3sh8A-4yfmA:
39.8		 3sh8A-4yfmA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		6 / 12 SER A  71
LYS A  74
SER A 131
ASN A 133
LYS A 233
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
 0.21A 3sh8B-4yfmA:
39.4		 3sh8B-4yfmA:
45.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		4 / 5 ASP A 164
THR A 179
GLU A 150
LYS A 147
 None
 1.12A 4a3pA-4yfmA:
undetectable		 4a3pA-4yfmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 9 ILE A 140
GLY A 145
VAL A  73
THR A 149
ARG A  66
 None
 1.38A 4acaB-4yfmA:
undetectable
4acaC-4yfmA:
undetectable		 4acaB-4yfmA:
21.14
4acaC-4yfmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		4 / 7 THR A  75
ASN A 243
LEU A 261
PHE A  76
 None
 1.35A 4awuA-4yfmA:
undetectable		 4awuA-4yfmA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 LYS A  74
SER A 131
ASN A 133
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
 ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
 0.41A 4euzA-4yfmA:
40.5		 4euzA-4yfmA:
45.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 SER A 131
ASN A 133
LYS A 233
THR A 234
GLY A 235
 ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
 0.52A 4fh2A-4yfmA:
34.7		 4fh2A-4yfmA:
35.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 12 LEU A 123
CYH A 124
ALA A  80
GLY A 145
LEU A 143
 None
 1.21A 4j7xB-4yfmA:
undetectable		 4j7xB-4yfmA:
26.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 SER A  71
SER A 131
ASN A 133
ASN A 171
LYS A 233
THR A 234
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
 0.25A 4n9kA-4yfmA:
41.1		 4n9kA-4yfmA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 SER A  71
SER A 131
ASN A 133
ASN A 171
LYS A 233
THR A 234
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
 0.29A 4n9kB-4yfmA:
40.9		 4n9kB-4yfmA:
46.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A  61
GLU A  65
ASP A  64
GLY A  60
PHE A  67
 None
 1.50A 4pfjA-4yfmA:
undetectable		 4pfjA-4yfmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A  61
GLU A  65
ASP A  64
GLY A  60
PHE A  67
 None
 1.49A 4pfjB-4yfmA:
undetectable		 4pfjB-4yfmA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 SER A 131
ASN A 133
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.61A 4pm5A-4yfmA:
41.8		 4pm5A-4yfmA:
44.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 LYS A  74
SER A 131
ASN A 133
ASN A 171
THR A 215
LYS A 233
GLY A 235
GLY A 237
 ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.65A 4pm7A-4yfmA:
41.7		 4pm7A-4yfmA:
44.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 SER A 131
ASN A 133
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.60A 4pm9A-4yfmA:
41.9		 4pm9A-4yfmA:
42.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A  61
GLU A  65
ASP A  64
GLY A  60
PHE A  67
 None
 1.46A 5axaA-4yfmA:
undetectable		 5axaA-4yfmA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.11A 5eevA-4yfmA:
undetectable
5eevB-4yfmA:
undetectable		 5eevA-4yfmA:
15.00
5eevB-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.11A 5eewA-4yfmA:
undetectable
5eewB-4yfmA:
undetectable		 5eewA-4yfmA:
15.00
5eewB-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.11A 5eexA-4yfmA:
undetectable
5eexB-4yfmA:
undetectable		 5eexA-4yfmA:
15.00
5eexB-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.11A 5eeyA-4yfmA:
undetectable
5eeyB-4yfmA:
undetectable		 5eeyA-4yfmA:
15.00
5eeyB-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.11A 5eezA-4yfmA:
undetectable
5eezB-4yfmA:
undetectable		 5eezA-4yfmA:
15.00
5eezB-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.11A 5ef0A-4yfmA:
undetectable
5ef0B-4yfmA:
undetectable		 5ef0A-4yfmA:
15.00
5ef0B-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.12A 5ef1A-4yfmA:
undetectable
5ef1B-4yfmA:
undetectable		 5ef1A-4yfmA:
15.00
5ef1B-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.11A 5ef2A-4yfmA:
undetectable
5ef2B-4yfmA:
undetectable		 5ef2A-4yfmA:
15.00
5ef2B-4yfmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 GLY A  44
GLY A 272
ALA A 279
THR A 262
ILE A 276
 None
 1.12A 5ef3A-4yfmA:
undetectable
5ef3B-4yfmA:
undetectable		 5ef3A-4yfmA:
15.00
5ef3B-4yfmA:
15.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		6 / 12 SER A  71
SER A 131
ASN A 133
ASN A 171
LYS A 233
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
 0.38A 5ghyA-4yfmA:
40.8		 5ghyA-4yfmA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		6 / 12 SER A  71
SER A 131
ASN A 133
ASN A 171
LYS A 233
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
 0.36A 5ghyB-4yfmA:
40.6		 5ghyB-4yfmA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 11 SER A  71
SER A 131
ASN A 133
ASN A 171
LYS A 233
THR A 234
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
 0.33A 5ghzA-4yfmA:
40.7		 5ghzA-4yfmA:
46.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 10 SER A  71
SER A 131
ASN A 133
ASN A 171
LYS A 233
THR A 234
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
 0.31A 5ghzB-4yfmA:
40.9		 5ghzB-4yfmA:
46.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 10 TYR A  98
ALA A 126
ILE A 109
GLY A 117
GLY A 135
 None
 1.25A 5i6xA-4yfmA:
undetectable		 5i6xA-4yfmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		4 / 6 PRO A 274
ARG A 281
THR A 280
ILE A 276
 None
 1.41A 5ih0A-4yfmA:
undetectable		 5ih0A-4yfmA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		4 / 6 LEU A 156
ILE A 140
THR A 149
MET A  69
 None
 1.44A 5ljeA-4yfmA:
undetectable		 5ljeA-4yfmA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		6 / 9 ILE A  46
GLY A  47
VAL A  48
ALA A 279
ILE A 220
ASN A 243
 None
 1.11A 5lw1B-4yfmA:
undetectable		 5lw1B-4yfmA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 12 TRP A 106
SER A 131
GLN A 169
THR A 215
GLY A 235
 None
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.3A)
 1.39A 5oj0A-4yfmA:
9.5		 5oj0A-4yfmA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		4 / 6 PHE A  67
VAL A 263
PHE A  42
THR A 275
 None
 0.80A 5t7bA-4yfmA:
undetectable		 5t7bA-4yfmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A  61
GLU A  65
ASP A  64
GLY A  60
PHE A  67
 None
 1.45A 5v96B-4yfmA:
undetectable		 5v96B-4yfmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 9 TYR A  98
ALA A 126
ILE A 109
GLY A 117
GLY A 135
 None
 1.28A 6awoA-4yfmA:
undetectable		 6awoA-4yfmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		5 / 9 TYR A  98
ALA A 126
ILE A 109
GLY A 117
GLY A 135
 None
 1.29A 6awqA-4yfmA:
undetectable		 6awqA-4yfmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		9 / 12 CYH A  70
SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 None
ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.40A 6b5yB-4yfmA:
39.7		 6b5yB-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		9 / 12 CYH A  70
SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 None
ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.39A 6b5yD-4yfmA:
39.6		 6b5yD-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		9 / 12 CYH A  70
SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 None
ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.28A 6b68B-4yfmA:
39.8		 6b68B-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
GLY A 235
GLY A 237
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.34A 6b68D-4yfmA:
39.7		 6b68D-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.28A 6b69A-4yfmA:
39.6
6b69B-4yfmA:
39.7		 6b69A-4yfmA:
17.83
6b69B-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		9 / 12 CYH A  70
SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 None
ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.30A 6b69D-4yfmA:
39.6		 6b69D-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		9 / 12 CYH A  70
SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 None
ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.32A 6b6aB-4yfmA:
39.5		 6b6aB-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 SER A  71
SER A 131
ASN A 171
LYS A 233
THR A 234
GLY A 235
GLY A 237
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.31A 6b6aD-4yfmA:
39.4		 6b6aD-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 SER A  71
SER A 131
ASN A 171
LYS A 233
THR A 234
GLY A 235
GLY A 237
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.38A 6b6cA-4yfmA:
39.4		 6b6cA-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		9 / 12 CYH A  70
SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 None
ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.53A 6b6dA-4yfmA:
39.2		 6b6dA-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 SER A  71
SER A 131
ASN A 171
THR A 215
LYS A 233
THR A 234
GLY A 235
GLY A 237
 ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.35A 6b6eA-4yfmA:
39.4		 6b6eA-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		8 / 12 CYH A  70
SER A  71
SER A 131
ASN A 171
LYS A 233
THR A 234
GLY A 235
GLY A 237
 None
ACT  A 301 (-3.5A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.5A)
ACT  A 301 (-3.3A)
None
 0.43A 6b6fA-4yfmA:
39.1		 6b6fA-4yfmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		7 / 12 SER A 131
ASN A 133
ASN A 171
THR A 215
LYS A 233
GLY A 235
GLY A 237
 ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.37A 6c79A-4yfmA:
42.4		 6c79A-4yfmA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		4 / 5 GLY A 157
ASN A 159
ASP A 158
ARG A 154
 None
 1.35A 6dwdB-4yfmA:
undetectable
6dwdD-4yfmA:
undetectable		 6dwdB-4yfmA:
20.47
6dwdD-4yfmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4yfm BETA-LACTAMASE
(Mycobacteroides
abscessus) 		4 / 5 ARG A 154
GLY A 157
ASN A 159
ASP A 158
 None
 1.31A 6dwjB-4yfmA:
undetectable
6dwjD-4yfmA:
undetectable		 6dwjB-4yfmA:
20.47
6dwjD-4yfmA:
20.47