SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4yfz OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		5 / 12 GLY A 223
HIS A 161
ILE A  84
LEU A 202
LEU A  65
 None
 1.20A 1r30B-4yfzA:
undetectable		 1r30B-4yfzA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4yfz OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		3 / 3 LEU A 109
ARG A 162
ILE A 108
 None
 0.63A 2xn5B-4yfzA:
undetectable		 2xn5B-4yfzA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4yfz OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		5 / 12 THR A 105
TYR A 191
GLY A 172
TYR A 166
ASN A 176
 None
 1.27A 3hiiA-4yfzA:
1.9		 3hiiA-4yfzA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4yfz OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		5 / 12 THR A 105
TYR A 191
GLY A 172
TYR A 166
ASN A 176
 None
 1.22A 3hiiB-4yfzA:
1.7		 3hiiB-4yfzA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4yfz OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		4 / 4 ASN A 176
SER A  74
LEU A  76
THR A 105
 None
 1.39A 4an2A-4yfzA:
undetectable		 4an2A-4yfzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4yfz OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		4 / 6 LYS A 222
GLY A 184
SER A 180
LEU A 186
 None
None
NAG  A1002 (-4.1A)
None
 1.28A 5bphA-4yfzA:
undetectable		 5bphA-4yfzA:
17.80