SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 4yg3 OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		4 / 6 ASN A  79
ASP A 169
GLY A 170
PRO A 196
 None
 0.89A 1n4fA-4yg3A:
undetectable		 1n4fA-4yg3A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4yg3 OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		4 / 7 TYR A 166
THR A 182
THR A 159
VAL A  92
 None
 1.13A 2fb2B-4yg3A:
undetectable		 2fb2B-4yg3A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4yg3 OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		5 / 12 THR A 105
TYR A 191
GLY A 172
TYR A 166
ASN A 176
 None
 1.18A 3hiiB-4yg3A:
1.4		 3hiiB-4yg3A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4yg3 OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		4 / 5 SER A  87
ARG A 162
TYR A 137
VAL A  92
 SO4  A 303 (-4.9A)
SO4  A 303 ( 3.0A)
None
None
 1.40A 3sufC-4yg3A:
undetectable		 3sufC-4yg3A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 4yg3 OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		4 / 6 LEU A 202
ASN A 201
MET A 122
VAL A 119
 None
 1.15A 4okbA-4yg3A:
undetectable		 4okbA-4yg3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4yg3 OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		4 / 8 ASP A 169
ILE A 174
ARG A 167
TYR A 177
 None
 1.14A 6hisC-4yg3A:
undetectable
6hisD-4yg3A:
undetectable		 6hisC-4yg3A:
19.33
6hisD-4yg3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4yg3 OUTER CAPSID PROTEIN
VP4
(Rotavirus
A) 		4 / 8 TYR A 177
ASP A 169
ILE A 174
ARG A 167
 None
 1.14A 6hisA-4yg3A:
undetectable
6hisE-4yg3A:
undetectable		 6hisA-4yg3A:
19.33
6hisE-4yg3A:
19.33