SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yg7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		3 / 3 ASP D 254
HIS D 311
ASP D 332
 None
 0.80A 1nw5A-4yg7D:
undetectable		 1nw5A-4yg7D:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		4 / 6 ALA D 159
TYR D 132
ILE D 169
PRO D 170
 None
 1.20A 1oniB-4yg7D:
undetectable
1oniC-4yg7D:
undetectable		 1oniB-4yg7D:
17.63
1oniC-4yg7D:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		4 / 6 ALA D 159
TYR D 132
ILE D 169
PRO D 170
 None
 1.17A 1oniH-4yg7D:
undetectable
1oniI-4yg7D:
undetectable		 1oniH-4yg7D:
17.63
1oniI-4yg7D:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		4 / 6 LEU D 350
ILE D 347
ARG D 432
VAL D 217
 None
 1.19A 2ygoA-4yg7D:
undetectable		 2ygoA-4yg7D:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		5 / 12 PHE D 315
PHE D 236
THR D 328
ALA D 336
ALA D 154
 None
 1.19A 3nxuB-4yg7D:
undetectable		 3nxuB-4yg7D:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		4 / 5 ILE D 163
THR D 177
GLU D 221
GLU D 234
 None
 1.20A 3ny4A-4yg7D:
undetectable		 3ny4A-4yg7D:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		5 / 10 ILE D 149
ASP D  96
LEU D 129
ILE D 184
ILE D 334
 None
 1.13A 3prsA-4yg7D:
undetectable		 3prsA-4yg7D:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		3 / 3 TYR D 331
MET D 296
LEU D 282
 None
 0.98A 3vw1D-4yg7D:
undetectable		 3vw1D-4yg7D:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		4 / 6 HIS D  24
SER D  91
ASP D  73
ASP D  88
 None
 1.32A 4blvA-4yg7D:
undetectable		 4blvA-4yg7D:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		5 / 10 ALA D 421
ILE D 366
HIS D 346
LEU D 350
ILE D 347
 None
 1.24A 4dtaA-4yg7D:
5.1		 4dtaA-4yg7D:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		4 / 5 ILE D 399
LEU D 427
ASP D 404
VAL D 418
 None
 1.06A 4nkxB-4yg7D:
undetectable		 4nkxB-4yg7D:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		3 / 3 PRO D 329
VAL D 233
HIS D 178
 None
 0.80A 4pevC-4yg7D:
undetectable		 4pevC-4yg7D:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		4 / 6 LEU D 282
PHE D 259
THR D 258
VAL D 317
 None
 1.11A 4udaA-4yg7D:
undetectable		 4udaA-4yg7D:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		4 / 6 ALA D 376
THR D 377
VAL D 380
HIS D 373
 None
 1.05A 5eclA-4yg7D:
undetectable		 5eclA-4yg7D:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		5 / 6 ILE D 275
ALA D 376
THR D 377
VAL D 380
HIS D 373
 None
 1.44A 5eclD-4yg7D:
undetectable		 5eclD-4yg7D:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		4 / 8 HIS D 430
VAL D 426
LEU D 403
ALA D 402
 None
 0.69A 5tt3H-4yg7D:
undetectable		 5tt3H-4yg7D:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA
(Escherichia
coli) 		5 / 11 LEU D 129
VAL D 128
ILE D 149
ALA D 232
LEU D 160
 None
 1.24A 6h1lB-4yg7D:
undetectable		 6h1lB-4yg7D:
24.90