SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 734
LEU B 697
LEU B 678
LEU B 264
 None
 0.77A 1errA-4yg8B:
undetectable		 1errA-4yg8B:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 10 LEU B 250
LEU B 227
THR B 288
ILE B 291
THR B 292
 None
 1.38A 1i18A-4yg8B:
undetectable
1i18B-4yg8B:
undetectable		 1i18A-4yg8B:
8.87
1i18B-4yg8B:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 10 LEU B 250
LEU B 227
THR B 288
ILE B 291
THR B 292
 None
 1.38A 1i18A-4yg8B:
undetectable
1i18B-4yg8B:
undetectable		 1i18A-4yg8B:
8.87
1i18B-4yg8B:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 201
GLY B 100
TYR B 134
ILE B  76
ARG B 186
 None
 1.36A 1tmxB-4yg8B:
undetectable		 1tmxB-4yg8B:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 4 ASP B 596
LEU B 618
LEU B 621
LEU B 599
 None
 1.12A 1u18A-4yg8B:
undetectable		 1u18A-4yg8B:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 5 TRP B 736
PRO B 205
LEU B  35
GLY B  31
 None
 1.46A 1ya4C-4yg8B:
0.2		 1ya4C-4yg8B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 352
TYR B 353
LYS B 384
 None
 1.19A 2othA-4yg8B:
undetectable		 2othA-4yg8B:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 315
LEU B 312
LEU B 308
THR B 344
VAL B 246
 None
 1.22A 2qd3A-4yg8B:
undetectable		 2qd3A-4yg8B:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 10 PHE B  51
ARG B 148
ILE B 160
ILE B  62
GLY B  52
 None
GOL  B 802 (-4.0A)
None
None
None
 1.36A 2v0mA-4yg8B:
undetectable		 2v0mA-4yg8B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 179
ALA A 232
LEU A 229
ASP A 189
PRO A 242
 None
 1.11A 2zulA-4yg8A:
undetectable		 2zulA-4yg8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 179
ALA A 232
LEU A 229
ASP A 189
PRO A 242
 None
 1.10A 3dmhA-4yg8A:
undetectable		 3dmhA-4yg8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 10 ILE B  46
ILE B 457
LEU B 453
ILE B 464
TYR B 689
 None
 1.14A 3hbbA-4yg8B:
undetectable		 3hbbA-4yg8B:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 11 PHE B 371
TRP B 523
GLY B 530
GLU B 534
ILE B 535
 None
 1.37A 3owxA-4yg8B:
undetectable
3owxB-4yg8B:
undetectable		 3owxA-4yg8B:
14.14
3owxB-4yg8B:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 174
SER A 193
ILE A 192
VAL A 176
VAL A 216
 None
 1.36A 3rf4A-4yg8A:
undetectable
3rf4B-4yg8A:
undetectable		 3rf4A-4yg8A:
16.78
3rf4B-4yg8A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 174
SER A 193
ILE A 192
VAL A 176
VAL A 216
 None
 1.32A 3rf4B-4yg8A:
undetectable
3rf4C-4yg8A:
undetectable		 3rf4B-4yg8A:
16.78
3rf4C-4yg8A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 5 TYR B 353
LEU A  71
LYS A  69
ARG B 350
 None
 1.47A 3sudD-4yg8B:
undetectable		 3sudD-4yg8B:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 340
PHE B 346
LEU B 347
LEU A  71
GLN A  67
 None
 1.28A 3tbgA-4yg8B:
undetectable		 3tbgA-4yg8B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 340
PHE B 346
LEU B 347
LEU A  71
GLN A  67
 None
 1.28A 3tbgC-4yg8B:
undetectable		 3tbgC-4yg8B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 6 THR B 158
CYH B 135
ASP B 144
ILE B  62
 None
 1.49A 3w9tB-4yg8B:
undetectable		 3w9tB-4yg8B:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 232
GLY A 179
PRO A 180
LEU A 229
 None
 0.96A 4dubA-4yg8A:
undetectable		 4dubA-4yg8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 315
LEU B 312
LEU B 308
THR B 344
VAL B 246
 None
 1.21A 4f4dA-4yg8B:
undetectable		 4f4dA-4yg8B:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 8 LYS B 527
ARG B 379
TYR B 375
ASP B 295
 None
 1.40A 4kr4C-4yg8B:
undetectable		 4kr4C-4yg8B:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		6 / 12 LEU B 678
LEU B 653
ASN B 191
PHE B 695
LEU B 700
MET B 733
 None
None
EPE  B 801 (-4.9A)
EPE  B 801 ( 4.5A)
None
None
 1.36A 4lmnA-4yg8B:
undetectable		 4lmnA-4yg8B:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 338
TRP B 523
SER B 370
 None
 0.89A 4lrhB-4yg8B:
undetectable		 4lrhB-4yg8B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 338
TRP B 523
SER B 370
 None
 0.93A 4lrhF-4yg8B:
undetectable		 4lrhF-4yg8B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 512
THR B 516
ARG B 625
ASP B 596
LEU B 599
 None
 1.37A 4pbhA-4yg8B:
undetectable		 4pbhA-4yg8B:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 588
ASP B 592
ASN B 510
 None
 0.76A 4q5mA-4yg8B:
undetectable		 4q5mA-4yg8B:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 173
GLN A  91
ALA A 201
ILE A 199
 None
 0.83A 4txnA-4yg8A:
undetectable		 4txnA-4yg8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 173
GLN A  91
ALA A 201
ILE A 199
 None
 0.86A 4txnB-4yg8A:
undetectable		 4txnB-4yg8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 173
GLN A  91
ALA A 201
ILE A 199
 None
 0.85A 4txnC-4yg8A:
undetectable		 4txnC-4yg8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 173
GLN A  91
ALA A 201
ILE A 199
 None
 0.83A 4txnD-4yg8A:
undetectable		 4txnD-4yg8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 274
SER A 188
VAL A 176
VAL A 245
LEU A 204
 None
 1.16A 4wnvA-4yg8A:
undetectable		 4wnvA-4yg8A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 11 PHE B 371
TRP B 523
GLY B 530
GLU B 534
ILE B 535
 None
 1.27A 4zvmA-4yg8B:
undetectable
4zvmB-4yg8B:
undetectable		 4zvmA-4yg8B:
14.01
4zvmB-4yg8B:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 11 PHE B 371
TRP B 523
GLY B 530
GLU B 534
ILE B 535
 None
 1.44A 4zvmA-4yg8B:
undetectable
4zvmB-4yg8B:
undetectable		 4zvmA-4yg8B:
14.01
4zvmB-4yg8B:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 5 ILE B  78
ARG B  58
CYH B  54
GLU B  53
 None
 1.29A 5fseC-4yg8B:
2.1		 5fseC-4yg8B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 531
LEU B 586
LEU B 589
LEU B 544
 None
 1.00A 5gs4A-4yg8B:
undetectable		 5gs4A-4yg8B:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 4 TYR B 689
ASN B 465
ILE B 464
GLN B 456
 None
 1.26A 5hhjA-4yg8B:
0.0		 5hhjA-4yg8B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 11 GLU B 102
CYH B 692
ALA B 187
THR B 190
LEU B 222
 None
 1.13A 5lf7H-4yg8B:
undetectable
5lf7I-4yg8B:
undetectable		 5lf7H-4yg8B:
16.16
5lf7I-4yg8B:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 318
ILE B 307
THR B 311
MET B 290
 None
 1.25A 5ljeA-4yg8B:
undetectable		 5ljeA-4yg8B:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 4 ARG B 186
ILE B  76
TYR B  97
ILE B  78
 None
 1.24A 5odhG-4yg8B:
undetectable		 5odhG-4yg8B:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		4 / 4 GLU B 203
THR B 190
GLU B  77
HIS B  80
 None
None
None
GOL  B 802 ( 4.6A)
 1.18A 5utuF-4yg8B:
undetectable		 5utuF-4yg8B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 634
GLU B 617
LEU B 619
ILE B 622
ARG B 625
 None
 1.40A 5vlmE-4yg8B:
undetectable		 5vlmE-4yg8B:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6
(Saccharomyces
cerevisiae) 		3 / 3 THR B 344
GLU B 534
ASN B 376
 None
 0.78A 6nj9K-4yg8B:
undetectable		 6nj9K-4yg8B:
19.30