SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ygs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4ygs HYDROLASE
(Thermococcus
onnurineus) 		5 / 9 LEU A  95
VAL A   4
GLY A 106
LEU A 124
TYR A 127
 None
 1.41A 1lwfA-4ygsA:
undetectable		 1lwfA-4ygsA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ygs HYDROLASE
(Thermococcus
onnurineus) 		4 / 5 TYR A 114
LYS A 118
LEU A  18
GLU A  15
 None
 1.29A 4z4hA-4ygsA:
2.8		 4z4hA-4ygsA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4ygs HYDROLASE
(Thermococcus
onnurineus) 		4 / 5 TYR A 114
LYS A 118
LEU A  18
GLU A  15
 None
 1.19A 5js1A-4ygsA:
4.0		 5js1A-4ygsA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4ygs HYDROLASE
(Thermococcus
onnurineus) 		4 / 6 LEU A  23
TYR A 114
ASP A   9
GLU A  15
 None
 1.42A 6djzC-4ygsA:
undetectable		 6djzC-4ygsA:
23.79