SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ygu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ygu PUTATIVE ADHESIN
(Bacteroides
eggerthii) 		5 / 9 PHE A 132
VAL A 130
LEU A 127
PHE A 119
LEU A 145
 None
 1.32A 1wrkA-4yguA:
undetectable
1wrkB-4yguA:
undetectable		 1wrkA-4yguA:
18.54
1wrkB-4yguA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4ygu PUTATIVE ADHESIN
(Bacteroides
eggerthii) 		5 / 10 ALA A 105
LEU A 145
LEU A 108
LYS A 109
LEU A 125
 None
 1.15A 2xn6A-4yguA:
undetectable
2xn6B-4yguA:
undetectable		 2xn6A-4yguA:
22.25
2xn6B-4yguA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ygu PUTATIVE ADHESIN
(Bacteroides
eggerthii) 		5 / 11 VAL A  68
PHE A  84
GLY A  47
GLY A 117
ILE A  49
 None
 1.36A 4zvmA-4yguA:
undetectable
4zvmB-4yguA:
undetectable		 4zvmA-4yguA:
22.92
4zvmB-4yguA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ygu PUTATIVE ADHESIN
(Bacteroides
eggerthii) 		5 / 12 ILE A  49
GLU A 112
PHE A  38
ALA A 105
SER A 131
 None
 1.32A 5iwuA-4yguA:
undetectable		 5iwuA-4yguA:
20.26