SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 10 ALA A 169
LEU A 192
LYS A 191
ILE A 152
TYR A 139
 None
 1.46A 1tdrB-4yh2A:
undetectable		 1tdrB-4yh2A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		3 / 3 GLY A 203
ARG A 207
TYR A 198
 None
 0.65A 2opxA-4yh2A:
undetectable		 2opxA-4yh2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		4 / 8 TYR A 139
ARG A 184
ILE A 185
ASP A 140
 None
 1.13A 2xytE-4yh2A:
undetectable		 2xytE-4yh2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		4 / 8 TYR A 139
ARG A 184
ILE A 185
ASP A 140
 None
 1.08A 2xytH-4yh2A:
undetectable		 2xytH-4yh2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 12 GLU A 193
ASN A 202
GLY A 203
VAL A 142
ILE A 189
 None
 1.00A 3k13A-4yh2A:
undetectable		 3k13A-4yh2A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 12 GLU A 193
ASN A 202
GLY A 203
VAL A 142
ILE A 189
 None
 0.97A 3k13B-4yh2A:
undetectable		 3k13B-4yh2A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 12 GLU A 193
ASN A 202
GLY A 203
VAL A 142
ILE A 189
 None
 0.99A 3k13C-4yh2A:
undetectable		 3k13C-4yh2A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		3 / 3 ASN A 110
ALA A 134
ARG A 131
 None
 0.82A 3tj7C-4yh2A:
undetectable
3tj7D-4yh2A:
undetectable		 3tj7C-4yh2A:
20.83
3tj7D-4yh2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		4 / 6 PHE A 162
SER A 166
ALA A  17
LEU A 164
 None
 1.20A 5dzkB-4yh2A:
undetectable
5dzkP-4yh2A:
undetectable		 5dzkB-4yh2A:
25.48
5dzkP-4yh2A:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		4 / 7 VAL A 165
SER A 166
ALA A 169
GLY A 203
 None
 0.94A 5fpdA-4yh2A:
undetectable		 5fpdA-4yh2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		4 / 7 LEU A 157
TRP A 188
VAL A 168
SER A 167
 None
 1.20A 5umwA-4yh2A:
undetectable
5umwF-4yh2A:
undetectable		 5umwA-4yh2A:
16.59
5umwF-4yh2A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 12 GLU A 193
ASN A 202
GLY A 203
VAL A 142
ILE A 189
 None
 0.97A 5vooB-4yh2A:
undetectable		 5vooB-4yh2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 12 GLU A 193
ASN A 202
GLY A 203
VAL A 142
ILE A 189
 None
 0.93A 5vooD-4yh2A:
undetectable		 5vooD-4yh2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 12 GLU A 193
ASN A 202
GLY A 203
VAL A 142
ILE A 189
 None
 0.92A 5vooF-4yh2A:
undetectable		 5vooF-4yh2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 12 GLU A 193
ASN A 202
GLY A 203
VAL A 142
ILE A 189
 None
 0.98A 5vopA-4yh2A:
undetectable		 5vopA-4yh2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 12 GLU A 193
ASN A 202
GLY A 203
VAL A 142
ILE A 189
 None
 1.02A 5vopB-4yh2A:
undetectable		 5vopB-4yh2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		4 / 6 ARG A  99
LEU A 100
ALA A  73
GLN A  98
 None
 0.80A 6b89B-4yh2A:
undetectable		 6b89B-4yh2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4yh2 GLUTATHIONE S
TRANSFERASE E6
(Drosophila
melanogaster) 		5 / 12 LEU A 192
ILE A 152
VAL A 107
THR A 158
LEU A  85
 None
 1.26A 6djzB-4yh2A:
undetectable		 6djzB-4yh2A:
22.51