SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 4yh8 SPLICING FACTOR U2AF
23 KDA SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 CYH A 157
CYH A 163
HIS A 167
 ZN  A 302 (-2.3A)
ZN  A 302 (-2.3A)
ZN  A 302 (-3.3A)
 0.87A 2iwkB-4yh8A:
undetectable		 2iwkB-4yh8A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4yh8 SPLICING FACTOR U2AF
23 KDA SUBUNIT
SPLICING FACTOR U2AF
59 KDA SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 6 TRP B 128
TYR A  77
GLN A 183
ILE B 125
 None
 1.33A 2pgzD-4yh8B:
undetectable
2pgzE-4yh8B:
undetectable		 2pgzD-4yh8B:
21.09
2pgzE-4yh8B:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4yh8 SPLICING FACTOR U2AF
23 KDA SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 CYH A  27
HIS A 102
PHE A  20
 ZN  A 301 (-2.4A)
None
None
 1.14A 3cr4X-4yh8A:
undetectable		 3cr4X-4yh8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4yh8 SPLICING FACTOR U2AF
23 KDA SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 8 ASN A  60
PRO A  59
PHE A  64
TYR A  52
 None
 1.42A 5amkA-4yh8A:
undetectable		 5amkA-4yh8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4yh8 SPLICING FACTOR U2AF
23 KDA SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A 161
ASP A 101
HIS A  57
ASN A  98
 None
 1.00A 5nnwD-4yh8A:
undetectable		 5nnwD-4yh8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4yh8 SPLICING FACTOR U2AF
23 KDA SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A 161
ASP A 101
HIS A  57
ASN A  98
 None
 0.97A 5no9D-4yh8A:
undetectable		 5no9D-4yh8A:
19.34