SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yhb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 7 ASP A  52
ASP A  48
TYR A 137
ARG A   8
 None
 1.30A 1ceaB-4yhbA:
undetectable		 1ceaB-4yhbA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 4 LEU A  56
LEU A 129
SER A  17
LEU A  68
 None
None
None
MPD  A 303 (-4.6A)
 1.09A 1ya3A-4yhbA:
undetectable		 1ya3A-4yhbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		5 / 11 THR A  29
ALA A 156
GLU A 160
ASP A 184
PHE A 172
 None
 1.32A 2admA-4yhbA:
4.0		 2admA-4yhbA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 6 ALA A 155
PHE A 172
ILE A 191
VAL A 168
 None
 0.96A 2cizA-4yhbA:
undetectable		 2cizA-4yhbA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 6 PHE A 172
ILE A 191
VAL A 168
ALA A 185
 None
 0.77A 2j5mA-4yhbA:
undetectable		 2j5mA-4yhbA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 6 ARG A  87
GLY A 113
PHE A  58
PRO A  61
 FAD  A 301 (-3.8A)
FAD  A 301 (-3.6A)
None
None
 0.90A 2m2oB-4yhbA:
undetectable		 2m2oB-4yhbA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		5 / 12 GLY A 254
GLY A 226
LEU A 263
ASN A 262
GLU A 251
 None
 1.12A 2zw9B-4yhbA:
3.3		 2zw9B-4yhbA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 6 THR A  90
VAL A  91
GLU A 161
SER A  47
 FAD  A 301 (-3.9A)
None
None
None
 0.92A 3b6rB-4yhbA:
undetectable		 3b6rB-4yhbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		3 / 3 ARG A  92
ASP A  36
ASP A 104
 None
 0.79A 3jb2A-4yhbA:
4.3		 3jb2A-4yhbA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		3 / 3 ARG A  92
ASP A  36
ASP A 104
 None
 0.77A 3jb3A-4yhbA:
undetectable		 3jb3A-4yhbA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		3 / 3 ARG A 242
GLU A 215
THR A 214
 None
 0.85A 3v4tA-4yhbA:
undetectable		 3v4tA-4yhbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 7 TYR A 255
ASP A 253
ARG A   8
HIS A 265
 FAD  A 301 (-3.5A)
None
None
ZN  A 302 ( 3.4A)
 1.27A 3zodA-4yhbA:
undetectable		 3zodA-4yhbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 6 HIS A 265
HIS A  53
TYR A 255
TYR A 137
 ZN  A 302 ( 3.4A)
ZN  A 302 ( 3.4A)
FAD  A 301 (-3.5A)
None
 1.35A 4df2A-4yhbA:
undetectable		 4df2A-4yhbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		5 / 10 PHE A 105
LEU A  56
VAL A  54
LEU A  37
VAL A 128
 None
 0.98A 4e3hA-4yhbA:
undetectable		 4e3hA-4yhbA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 8 LEU A 207
THR A 214
ALA A 210
LEU A 206
 None
 0.98A 4ik6B-4yhbA:
undetectable		 4ik6B-4yhbA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		4 / 6 LEU A 207
THR A 214
ALA A 210
LEU A 206
 None
 1.05A 4pwjA-4yhbA:
undetectable		 4pwjA-4yhbA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4yhb IRON-CHELATOR
UTILIZATION PROTEIN
(Thermobifida
fusca) 		5 / 12 LEU A  37
ASP A 124
LEU A 126
THR A 102
ARG A  34
 None
 1.12A 6b0lB-4yhbA:
undetectable		 6b0lB-4yhbA:
14.07