SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 9 VAL A 590
VAL A1030
LEU A 624
ILE A 601
LEU A1045
 None
 1.17A 1eqgA-4yhcA:
undetectable		 1eqgA-4yhcA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 11 VAL A 590
VAL A1030
LEU A 624
ILE A 601
LEU A1045
 None
 1.17A 1eqgB-4yhcA:
undetectable		 1eqgB-4yhcA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 8 VAL A 613
LEU A 642
SER A 655
VAL A 654
 None
 1.16A 1jtvA-4yhcA:
undetectable		 1jtvA-4yhcA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 686
SER A 680
SER A 658
LEU A 674
HIS A 676
 None
 1.42A 1rk3A-4yhcA:
undetectable		 1rk3A-4yhcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 PRO A 692
GLY A 693
ASP A 648
PHE A 717
PHE A 657
 None
 1.45A 2b9eA-4yhcA:
undetectable		 2b9eA-4yhcA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 7 SER A 838
SER A 850
SER A 851
GLN A1003
 None
 0.97A 2cmlA-4yhcA:
7.7		 2cmlA-4yhcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 838
SER A 850
SER A 851
GLN A1003
 None
 1.05A 2cmlB-4yhcA:
5.3		 2cmlB-4yhcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 838
SER A 850
SER A 851
GLN A1003
 None
 1.08A 2cmlD-4yhcA:
6.9		 2cmlD-4yhcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 819
ASP A 799
ILE A 795
GLY A 794
ILE A 792
 None
 1.11A 2o4kA-4yhcA:
undetectable		 2o4kA-4yhcA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 8 PRO A 895
ASP A 896
SER A 873
SER A 838
 None
 1.23A 2p02A-4yhcA:
undetectable		 2p02A-4yhcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 719
LEU A 705
VAL A 707
GLN A 715
ILE A 664
 None
 1.23A 2q6hA-4yhcA:
undetectable		 2q6hA-4yhcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 689
SER A 767
ALA A 751
LEU A 814
ILE A 744
 None
CIT  A1102 ( 4.6A)
CIT  A1102 ( 4.2A)
None
None
 1.20A 2xkwB-4yhcA:
undetectable		 2xkwB-4yhcA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 686
SER A 680
SER A 658
LEU A 674
HIS A 676
 None
 1.41A 2zlcA-4yhcA:
undetectable		 2zlcA-4yhcA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A 569
MET A1015
PRO A 589
GLY A1040
ILE A1021
 None
 1.43A 3jb2A-4yhcA:
undetectable		 3jb2A-4yhcA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		3 / 3 SER A 569
SER A1018
HIS A 593
 None
 0.69A 3mzeA-4yhcA:
undetectable		 3mzeA-4yhcA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 686
SER A 680
SER A 658
LEU A 674
HIS A 676
 None
 1.39A 3vt3A-4yhcA:
undetectable		 3vt3A-4yhcA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 686
SER A 680
SER A 658
LEU A 674
HIS A 676
 None
 1.40A 3vt7A-4yhcA:
undetectable		 3vt7A-4yhcA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 809
LEU A 825
ILE A 828
VAL A 835
 None
 0.89A 4a9kA-4yhcA:
undetectable		 4a9kA-4yhcA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 8 PRO A 895
ASP A 896
SER A 873
SER A 838
 None
 1.22A 4ndnA-4yhcA:
undetectable		 4ndnA-4yhcA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 631
VAL A 620
LEU A 642
GLY A 614
SER A 612
 None
 1.24A 4zbqA-4yhcA:
undetectable		 4zbqA-4yhcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A1013
ILE A 587
PRO A 589
LEU A1039
 None
 1.11A 5eb3A-4yhcA:
undetectable		 5eb3A-4yhcA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A 607
TYR A 866
SER A 834
 None
 0.95A 5iktB-4yhcA:
undetectable		 5iktB-4yhcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 648
SER A 669
ASN A 666
SER A 604
 None
 1.10A 5l1fA-4yhcA:
undetectable
5l1fB-4yhcA:
undetectable		 5l1fA-4yhcA:
20.12
5l1fB-4yhcA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE A 792
PHE A 802
VAL A 763
ASP A 799
ILE A 812
 None
 1.03A 5lg3H-4yhcA:
undetectable		 5lg3H-4yhcA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 642
GLY A 614
LEU A 665
LEU A 633
MET A 638
 None
 1.12A 5nfjB-4yhcA:
undetectable		 5nfjB-4yhcA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 642
GLY A 614
LEU A 665
LEU A 633
MET A 638
 None
 1.10A 5nfjC-4yhcA:
undetectable		 5nfjC-4yhcA:
19.46