SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yhp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4yhp FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 TYR A 153
HIS A 208
LEU A 116
ALA A 176
THR A  91
 None
 1.29A 3jwqB-4yhpA:
undetectable
3jwqC-4yhpA:
undetectable		 3jwqB-4yhpA:
18.26
3jwqC-4yhpA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4yhp FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA A  92
THR A  91
VAL A 117
GLU A  89
 None
 0.75A 5ecmD-4yhpA:
undetectable		 5ecmD-4yhpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4yhp FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA A  92
THR A  91
VAL A 117
GLU A  89
 None
 0.83A 5ecoD-4yhpA:
undetectable		 5ecoD-4yhpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4yhp FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 7 PHE A 100
GLY A 103
GLY A 105
HIS A 107
 None
 1.04A 5n9xA-4yhpA:
undetectable		 5n9xA-4yhpA:
17.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4yhp FAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 TYR A  60
GLY A  66
THR A  69
 None
 0.16A 6cjkB-4yhpA:
25.5		 6cjkB-4yhpA:
61.64