SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 9 ILE A 141
PRO A 142
ALA A 137
ILE A 136
THR A 116
None
1.50A 1aj6A-4yhsA:
undetectable
1aj6A-4yhsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 ILE A 136
ALA A 118
GLN A 104
ASN A 148
THR A 116
None
1.13A 1dhfA-4yhsA:
undetectable
1dhfA-4yhsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 ARG A 303
PRO A 338
VAL A 337
ALA A 295
PHE A 327
None
1.12A 1gseA-4yhsA:
2.0
1gseA-4yhsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.06A 1gtnB-4yhsA:
undetectable
1gtnC-4yhsA:
undetectable
1gtnB-4yhsA:
14.02
1gtnC-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.05A 1gtnH-4yhsA:
undetectable
1gtnI-4yhsA:
undetectable
1gtnH-4yhsA:
14.02
1gtnI-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 11 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.03A 1gtnM-4yhsA:
undetectable
1gtnN-4yhsA:
undetectable
1gtnM-4yhsA:
14.02
1gtnN-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.02A 1gtnU-4yhsA:
undetectable
1gtnV-4yhsA:
undetectable
1gtnU-4yhsA:
14.02
1gtnV-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.03A 1utdO-4yhsA:
undetectable
1utdP-4yhsA:
undetectable
1utdO-4yhsA:
14.02
1utdP-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 11 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.04A 1utdP-4yhsA:
undetectable
1utdQ-4yhsA:
undetectable
1utdP-4yhsA:
14.02
1utdQ-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.03A 1utdT-4yhsA:
undetectable
1utdU-4yhsA:
undetectable
1utdT-4yhsA:
14.02
1utdU-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.23A 1zzrA-4yhsA:
undetectable
1zzrB-4yhsA:
undetectable
1zzrA-4yhsA:
22.62
1zzrB-4yhsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.24A 1zzrA-4yhsA:
undetectable
1zzrB-4yhsA:
undetectable
1zzrA-4yhsA:
22.62
1zzrB-4yhsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.24A 1zzuA-4yhsA:
undetectable
1zzuB-4yhsA:
undetectable
1zzuA-4yhsA:
22.62
1zzuB-4yhsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.23A 1zzuA-4yhsA:
undetectable
1zzuB-4yhsA:
undetectable
1zzuA-4yhsA:
22.62
1zzuB-4yhsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 5 LEU A  60
GLY A 315
PRO A 142
ALA A 118
None
0.89A 2aohA-4yhsA:
undetectable
2aohA-4yhsA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 ARG A 311
ALA A 157
PRO A 142
ALA A 156
None
0.96A 2ejfA-4yhsA:
undetectable
2ejfA-4yhsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 ILE A 136
ALA A 118
GLN A 104
ASN A 148
THR A 116
None
1.04A 2w3mA-4yhsA:
undetectable
2w3mA-4yhsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 ILE A 136
ALA A 118
GLN A 104
ASN A 148
THR A 116
None
1.09A 2w3mB-4yhsA:
undetectable
2w3mB-4yhsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 PRO A 191
GLY A 192
GLY A 223
LEU A 273
ILE A 290
None
0.97A 3douA-4yhsA:
3.0
3douA-4yhsA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.28A 3dqrA-4yhsA:
undetectable
3dqrB-4yhsA:
undetectable
3dqrA-4yhsA:
22.92
3dqrB-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 8 TYR A  48
ASP A 307
GLY A  87
SER A  83
None
0.87A 3ihzB-4yhsA:
undetectable
3ihzB-4yhsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.29A 3jx2A-4yhsA:
undetectable
3jx2B-4yhsA:
undetectable
3jx2A-4yhsA:
22.92
3jx2B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.27A 3jx3A-4yhsA:
undetectable
3jx3B-4yhsA:
undetectable
3jx3A-4yhsA:
22.92
3jx3B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.28A 3jx3A-4yhsA:
undetectable
3jx3B-4yhsA:
undetectable
3jx3A-4yhsA:
22.92
3jx3B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 6 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.31A 3jx4A-4yhsA:
undetectable
3jx4B-4yhsA:
undetectable
3jx4A-4yhsA:
22.92
3jx4B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.28A 3jx4A-4yhsA:
undetectable
3jx4B-4yhsA:
undetectable
3jx4A-4yhsA:
22.92
3jx4B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.26A 3jx5A-4yhsA:
undetectable
3jx5B-4yhsA:
undetectable
3jx5A-4yhsA:
22.92
3jx5B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 6 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.31A 3n61A-4yhsA:
undetectable
3n61B-4yhsA:
undetectable
3n61A-4yhsA:
22.92
3n61B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.32A 3n61A-4yhsA:
undetectable
3n61B-4yhsA:
undetectable
3n61A-4yhsA:
22.92
3n61B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.28A 3nlpA-4yhsA:
undetectable
3nlpB-4yhsA:
undetectable
3nlpA-4yhsA:
22.92
3nlpB-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.30A 3nlpA-4yhsA:
undetectable
3nlpB-4yhsA:
undetectable
3nlpA-4yhsA:
22.92
3nlpB-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.29A 3nlqA-4yhsA:
undetectable
3nlqB-4yhsA:
undetectable
3nlqA-4yhsA:
22.92
3nlqB-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.25A 3nlrA-4yhsA:
undetectable
3nlrB-4yhsA:
undetectable
3nlrA-4yhsA:
22.92
3nlrB-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 GLU A 100
GLY A  97
PHE A  64
ASP A  69
ASN A 148
None
CL  A 402 ( 3.7A)
None
BTB  A 401 (-4.0A)
None
1.39A 3ps9A-4yhsA:
2.6
3ps9A-4yhsA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 11 TYR A 318
LEU A 313
ALA A 305
ILE A 304
THR A 116
None
1.40A 3qelA-4yhsA:
11.9
3qelB-4yhsA:
8.5
3qelA-4yhsA:
22.25
3qelB-4yhsA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 PHE A 206
TYR A 173
GLY A 205
ALA A 209
SER A  43
None
1.10A 3sudB-4yhsA:
undetectable
3sudB-4yhsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ILE A 124
LEU A 101
GLY A 122
ASP A 145
GLY A 149
None
1.04A 4bwlC-4yhsA:
undetectable
4bwlC-4yhsA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.28A 4cx3A-4yhsA:
undetectable
4cx3B-4yhsA:
undetectable
4cx3A-4yhsA:
22.92
4cx3B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.25A 4cx3A-4yhsA:
undetectable
4cx3B-4yhsA:
undetectable
4cx3A-4yhsA:
22.92
4cx3B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.28A 4cx4A-4yhsA:
undetectable
4cx4B-4yhsA:
undetectable
4cx4A-4yhsA:
22.92
4cx4B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.27A 4cx4A-4yhsA:
undetectable
4cx4B-4yhsA:
undetectable
4cx4A-4yhsA:
22.92
4cx4B-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 ILE A 136
ALA A 118
GLN A 104
ASN A 148
THR A 116
None
1.07A 4kebB-4yhsA:
2.0
4kebB-4yhsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 11 HIS A 321
PRO A  36
ASP A 154
ASP A 145
ILE A 150
None
1.44A 4ktvC-4yhsA:
undetectable
4ktvD-4yhsA:
undetectable
4ktvC-4yhsA:
21.79
4ktvD-4yhsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 6 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.23A 5addA-4yhsA:
undetectable
5addB-4yhsA:
undetectable
5addA-4yhsA:
22.92
5addB-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 6 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.32A 5adeA-4yhsA:
undetectable
5adeB-4yhsA:
undetectable
5adeA-4yhsA:
22.92
5adeB-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.02A 5eeuF-4yhsA:
undetectable
5eeuG-4yhsA:
undetectable
5eeuF-4yhsA:
14.02
5eeuG-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.05A 5eeuI-4yhsA:
undetectable
5eeuJ-4yhsA:
undetectable
5eeuI-4yhsA:
14.02
5eeuJ-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.03A 5eeuO-4yhsA:
undetectable
5eeuP-4yhsA:
undetectable
5eeuO-4yhsA:
14.02
5eeuP-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.06A 5eeuQ-4yhsA:
undetectable
5eeuR-4yhsA:
undetectable
5eeuQ-4yhsA:
14.02
5eeuR-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.02A 5eevF-4yhsA:
undetectable
5eevG-4yhsA:
undetectable
5eevF-4yhsA:
14.02
5eevG-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.05A 5eevI-4yhsA:
undetectable
5eevJ-4yhsA:
undetectable
5eevI-4yhsA:
14.02
5eevJ-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.04A 5eevO-4yhsA:
undetectable
5eevP-4yhsA:
undetectable
5eevO-4yhsA:
14.02
5eevP-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.06A 5eevQ-4yhsA:
undetectable
5eevR-4yhsA:
undetectable
5eevQ-4yhsA:
14.02
5eevR-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.03A 5eewF-4yhsA:
undetectable
5eewG-4yhsA:
undetectable
5eewF-4yhsA:
14.02
5eewG-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.05A 5eewI-4yhsA:
undetectable
5eewJ-4yhsA:
undetectable
5eewI-4yhsA:
14.02
5eewJ-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.03A 5eewO-4yhsA:
undetectable
5eewP-4yhsA:
undetectable
5eewO-4yhsA:
14.02
5eewP-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.06A 5eewQ-4yhsA:
undetectable
5eewR-4yhsA:
undetectable
5eewQ-4yhsA:
14.02
5eewR-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.03A 5eexF-4yhsA:
undetectable
5eexG-4yhsA:
undetectable
5eexF-4yhsA:
14.02
5eexG-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.04A 5eexO-4yhsA:
undetectable
5eexP-4yhsA:
undetectable
5eexO-4yhsA:
14.02
5eexP-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.03A 5eeyF-4yhsA:
undetectable
5eeyG-4yhsA:
undetectable
5eeyF-4yhsA:
14.02
5eeyG-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.04A 5eeyO-4yhsA:
undetectable
5eeyP-4yhsA:
undetectable
5eeyO-4yhsA:
14.02
5eeyP-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.03A 5eezF-4yhsA:
undetectable
5eezG-4yhsA:
undetectable
5eezF-4yhsA:
14.02
5eezG-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.04A 5eezO-4yhsA:
undetectable
5eezP-4yhsA:
undetectable
5eezO-4yhsA:
14.02
5eezP-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.03A 5ef0F-4yhsA:
undetectable
5ef0G-4yhsA:
undetectable
5ef0F-4yhsA:
14.02
5ef0G-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.04A 5ef0O-4yhsA:
undetectable
5ef0P-4yhsA:
undetectable
5ef0O-4yhsA:
14.02
5ef0P-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.03A 5ef1F-4yhsA:
undetectable
5ef1G-4yhsA:
undetectable
5ef1F-4yhsA:
14.02
5ef1G-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.04A 5ef1O-4yhsA:
undetectable
5ef1P-4yhsA:
undetectable
5ef1O-4yhsA:
14.02
5ef1P-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.04A 5ef2F-4yhsA:
undetectable
5ef2G-4yhsA:
undetectable
5ef2F-4yhsA:
14.02
5ef2G-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.04A 5ef2O-4yhsA:
undetectable
5ef2P-4yhsA:
undetectable
5ef2O-4yhsA:
14.02
5ef2P-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 ALA A 274
GLY A 284
ALA A 293
THR A 278
ILE A 285
None
1.03A 5ef3F-4yhsA:
undetectable
5ef3G-4yhsA:
undetectable
5ef3F-4yhsA:
14.02
5ef3G-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 GLY A 284
ALA A 293
THR A 278
ILE A 285
ALA A 274
None
1.04A 5ef3O-4yhsA:
undetectable
5ef3P-4yhsA:
undetectable
5ef3O-4yhsA:
14.02
5ef3P-4yhsA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 TYR A 318
LEU A 313
ALA A 305
ILE A 304
THR A 116
None
1.37A 5ewjC-4yhsA:
12.9
5ewjD-4yhsA:
8.6
5ewjC-4yhsA:
21.63
5ewjD-4yhsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 VAL A 299
VAL A 147
TRP A  72
PHE A  64
None
1.28A 5g0pA-4yhsA:
undetectable
5g0pB-4yhsA:
undetectable
5g0pA-4yhsA:
22.92
5g0pB-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
4 / 7 TRP A  72
PHE A  64
VAL A 299
VAL A 147
None
1.30A 5g0pA-4yhsA:
undetectable
5g0pB-4yhsA:
undetectable
5g0pA-4yhsA:
22.92
5g0pB-4yhsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 10 MET A 207
PHE A 206
GLY A 167
ILE A 261
LEU A 266
None
1.19A 5oy01-4yhsA:
undetectable
5oy07-4yhsA:
undetectable
5oy01-4yhsA:
14.13
5oy07-4yhsA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 9 GLN A 230
GLY A 223
GLY A 192
ALA A 196
VAL A 199
None
1.30A 5v3cA-4yhsA:
undetectable
5v3cA-4yhsA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
3 / 3 TYR A  77
PRO A 344
LEU A  73
None
0.90A 6beoA-4yhsA:
undetectable
6beoA-4yhsA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp.
BTAi1)
5 / 12 LEU A 129
ILE A 150
ILE A 108
VAL A 112
ILE A 121
None
1.06A 6emuB-4yhsA:
undetectable
6emuB-4yhsA:
22.93