SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yhw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICU_A_NIOA221_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	4yhw	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 (Saccharomyces cerevisiae)	4 / 6	SER A 460 PHE A 458 PHE A 441 GLY A 367	None None U E 87 ( 3.3A) None	1.16A	1icuA-4yhwA: undetectable 1icuB-4yhwA: undetectable	1icuA-4yhwA: 18.30 1icuB-4yhwA: 18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICU_D_NIOD223_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	4yhw	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 (Saccharomyces cerevisiae)	4 / 5	PHE A 441 GLY A 367 SER A 460 PHE A 458	U E 87 ( 3.3A) None None None	1.07A	1icuC-4yhwA: undetectable 1icuD-4yhwA: undetectable	1icuC-4yhwA: 18.30 1icuD-4yhwA: 18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICV_B_NIOB702_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	4yhw	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 (Saccharomyces cerevisiae)	4 / 5	PHE A 441 GLY A 367 SER A 460 PHE A 458	U E 87 ( 3.3A) None None None	1.21A	1icvA-4yhwA: undetectable 1icvB-4yhwA: undetectable	1icvA-4yhwA: 18.30 1icvB-4yhwA: 18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_A_BEZA524_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	4yhw	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 (Saccharomyces cerevisiae)	4 / 6	SER A 460 PHE A 458 PHE A 441 GLY A 367	None None U E 87 ( 3.3A) None	1.17A	1kqbA-4yhwA: undetectable 1kqbB-4yhwA: undetectable	1kqbA-4yhwA: 18.47 1kqbB-4yhwA: 18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_C_BEZC522_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	4yhw	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 (Saccharomyces cerevisiae)	4 / 6	SER A 460 PHE A 458 PHE A 441 GLY A 367	None None U E 87 ( 3.3A) None	1.16A	1kqbC-4yhwA: undetectable 1kqbD-4yhwA: undetectable	1kqbC-4yhwA: 18.47 1kqbD-4yhwA: 18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_D_BEZD523_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	4yhw	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 (Saccharomyces cerevisiae)	4 / 6	PHE A 441 GLY A 367 SER A 460 PHE A 458	U E 87 ( 3.3A) None None None	1.15A	1kqbC-4yhwA: undetectable 1kqbD-4yhwA: undetectable	1kqbC-4yhwA: 18.47 1kqbD-4yhwA: 18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_C_VIAC903_2 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4yhw	U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 (Saccharomyces cerevisiae)	3 / 3	ASN A 346 ILE A 380 MET A 442	None None G E 86 ( 3.8A)	0.84A	2h42C-4yhwA: undetectable	2h42C-4yhwA: 20.97

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ICU_A_NIOA221_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","4yhw","U4\/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3","Saccharomyces cerevisiae",4,"SER A 460;PHE A 458;PHE A 441;GLY A 367","None;None;  U E  87 ( 3.3A);None","1.16A","1icuA-4yhwA:undetectable;1icuB-4yhwA:undetectable","1icuA-4yhwA:18.30;1icuB-4yhwA:18.30"],["1ICU_D_NIOD223_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","4yhw","U4\/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3","Saccharomyces cerevisiae",4,"PHE A 441;GLY A 367;SER A 460;PHE A 458","  U E  87 ( 3.3A);None;None;None","1.07A","1icuC-4yhwA:undetectable;1icuD-4yhwA:undetectable","1icuC-4yhwA:18.30;1icuD-4yhwA:18.30"],["1ICV_B_NIOB702_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","4yhw","U4\/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3","Saccharomyces cerevisiae",4,"PHE A 441;GLY A 367;SER A 460;PHE A 458","  U E  87 ( 3.3A);None;None;None","1.21A","1icvA-4yhwA:undetectable;1icvB-4yhwA:undetectable","1icvA-4yhwA:18.30;1icvB-4yhwA:18.30"],["1KQB_A_BEZA524_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","4yhw","U4\/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3","Saccharomyces cerevisiae",4,"SER A 460;PHE A 458;PHE A 441;GLY A 367","None;None;  U E  87 ( 3.3A);None","1.17A","1kqbA-4yhwA:undetectable;1kqbB-4yhwA:undetectable","1kqbA-4yhwA:18.47;1kqbB-4yhwA:18.47"],["1KQB_C_BEZC522_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","4yhw","U4\/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3","Saccharomyces cerevisiae",4,"SER A 460;PHE A 458;PHE A 441;GLY A 367","None;None;  U E  87 ( 3.3A);None","1.16A","1kqbC-4yhwA:undetectable;1kqbD-4yhwA:undetectable","1kqbC-4yhwA:18.47;1kqbD-4yhwA:18.47"],["1KQB_D_BEZD523_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","4yhw","U4\/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3","Saccharomyces cerevisiae",4,"PHE A 441;GLY A 367;SER A 460;PHE A 458","  U E  87 ( 3.3A);None;None;None","1.15A","1kqbC-4yhwA:undetectable;1kqbD-4yhwA:undetectable","1kqbC-4yhwA:18.47;1kqbD-4yhwA:18.47"],["2H42_C_VIAC903_2","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4yhw","U4\/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3","Saccharomyces cerevisiae",3,"ASN A 346;ILE A 380;MET A 442","None;None;  G E  86 ( 3.8A)","0.84A","2h42C-4yhwA:undetectable","2h42C-4yhwA:20.97"]]