SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		4 / 5 PHE A  42
PHE A  91
TRP A  61
GLY A  14
 None
 1.26A 2qmzA-4yhxA:
undetectable
2qmzB-4yhxA:
undetectable		 2qmzA-4yhxA:
21.02
2qmzB-4yhxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		4 / 6 VAL A  65
GLN A  43
GLY A  20
LEU A  96
 None
 1.08A 3bjwE-4yhxA:
undetectable		 3bjwE-4yhxA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		5 / 8 PHE A  42
TYR A 104
PHE A  91
TRP A  61
GLY A  14
 None
 1.45A 4qoiA-4yhxA:
undetectable
4qoiB-4yhxA:
undetectable		 4qoiA-4yhxA:
21.02
4qoiB-4yhxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		5 / 9 ALA A  16
VAL A  86
THR A  60
ILE A  44
VAL A  63
 None
 1.10A 4r21B-4yhxA:
undetectable		 4r21B-4yhxA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		5 / 12 ILE A 264
LEU A 268
GLU A  19
GLY A 182
GLY A 178
 None
None
CA  A 402 ( 2.8A)
CA  A 403 (-3.8A)
None
 1.17A 5l6eA-4yhxA:
undetectable		 5l6eA-4yhxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		5 / 12 GLY A  41
ILE A  23
PHE A  22
ASN A 136
LEU A 135
 None
 1.32A 5nz0A-4yhxA:
undetectable		 5nz0A-4yhxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		5 / 10 ILE A 254
ILE A 250
LEU A 203
ILE A 263
ASN A 262
 None
 1.40A 5vkqA-4yhxA:
undetectable
5vkqD-4yhxA:
undetectable		 5vkqA-4yhxA:
11.72
5vkqD-4yhxA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		5 / 10 ILE A 263
ASN A 262
ILE A 254
ILE A 250
LEU A 203
 None
 1.38A 5vkqA-4yhxA:
undetectable
5vkqB-4yhxA:
undetectable		 5vkqA-4yhxA:
11.72
5vkqB-4yhxA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		5 / 10 ILE A 263
ASN A 262
ILE A 254
ILE A 250
LEU A 203
 None
 1.39A 5vkqC-4yhxA:
undetectable
5vkqD-4yhxA:
undetectable		 5vkqC-4yhxA:
11.72
5vkqD-4yhxA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN
(Grosmannia
penicillata) 		4 / 8 GLN A  43
GLY A  41
TRP A  61
ASP A  83
 None
 1.01A 5vlmD-4yhxA:
undetectable		 5vlmD-4yhxA:
20.26