SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4yii ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens) 		4 / 8 ARG A 816
SER A 767
VAL A 814
SER A 811
 None
 1.22A 1hwiB-4yiiA:
undetectable		 1hwiB-4yiiA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4yii ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		5 / 11 LEU U 132
GLY U  64
LEU A 765
LEU U  42
MET U  43
 None
 1.01A 1mx1A-4yiiU:
undetectable		 1mx1A-4yiiU:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		3 / 3 PHE U  53
LEU U  39
MET U  44
 None
 0.86A 1mx1D-4yiiU:
undetectable		 1mx1D-4yiiU:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		4 / 8 ILE U 131
PHE U  85
GLY U  64
ILE U  66
 None
 0.97A 2qwxA-4yiiU:
undetectable
2qwxB-4yiiU:
undetectable		 2qwxA-4yiiU:
21.97
2qwxB-4yiiU:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		5 / 10 LEU U 132
LEU U  83
ALA U  52
LEU U  35
LEU U  42
 None
 1.08A 4p65A-4yiiU:
undetectable
4p65B-4yiiU:
undetectable
4p65F-4yiiU:
undetectable
4p65H-4yiiU:
undetectable		 4p65A-4yiiU:
8.06
4p65B-4yiiU:
11.03
4p65F-4yiiU:
11.03
4p65H-4yiiU:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		5 / 11 LEU U 132
LEU U  83
ALA U  52
LEU U  42
LEU U  35
 None
 1.02A 4p65C-4yiiU:
undetectable
4p65D-4yiiU:
undetectable
4p65J-4yiiU:
undetectable
4p65L-4yiiU:
undetectable		 4p65C-4yiiU:
8.06
4p65D-4yiiU:
11.03
4p65J-4yiiU:
11.03
4p65L-4yiiU:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		5 / 11 LEU U 132
LEU U  83
ALA U  52
LEU U  35
LEU U  42
 None
 0.94A 4p65E-4yiiU:
undetectable
4p65F-4yiiU:
undetectable
4p65J-4yiiU:
undetectable
4p65L-4yiiU:
undetectable		 4p65E-4yiiU:
8.06
4p65F-4yiiU:
11.03
4p65J-4yiiU:
11.03
4p65L-4yiiU:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		5 / 11 LEU U  42
LEU U  35
LEU U 132
LEU U  83
ALA U  52
 None
 1.09A 4p65B-4yiiU:
undetectable
4p65D-4yiiU:
undetectable
4p65G-4yiiU:
undetectable
4p65H-4yiiU:
undetectable		 4p65B-4yiiU:
11.03
4p65D-4yiiU:
11.03
4p65G-4yiiU:
8.06
4p65H-4yiiU:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		3 / 3 TYR U  79
THR U  65
THR U 100
 None
 0.77A 5aoxB-4yiiU:
undetectable		 5aoxB-4yiiU:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4yii ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		5 / 12 TYR A 757
LEU U  42
ILE A 758
PHE A 754
PRO U  54
 None
 1.50A 5ewjC-4yiiA:
undetectable
5ewjD-4yiiA:
undetectable		 5ewjC-4yiiA:
13.54
5ewjD-4yiiA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		4 / 5 LEU U  81
LEU U 118
PHE U  98
LEU U 138
 None
 1.01A 5gtrA-4yiiU:
undetectable		 5gtrA-4yiiU:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		4 / 8 TYR U  89
THR U  95
TRP U 122
LEU U 118
 None
 1.24A 5kxiA-4yiiU:
undetectable
5kxiB-4yiiU:
undetectable		 5kxiA-4yiiU:
18.13
5kxiB-4yiiU:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens) 		4 / 8 TYR U  89
THR U  95
TRP U 122
LEU U 118
 None
 1.31A 5kxiD-4yiiU:
undetectable
5kxiE-4yiiU:
undetectable		 5kxiD-4yiiU:
18.13
5kxiE-4yiiU:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4yii ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
UBIQUITIN-CONJUGATIN
G ENZYME E2 C
(Homo
sapiens;
Homo
sapiens) 		3 / 3 THR A 763
THR U  65
ARG U  78
 None
 1.06A 5wm2A-4yiiA:
undetectable		 5wm2A-4yiiA:
9.95