SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 4 ILE A 102
LEU A 200
VAL A 133
ILE A 158
 None
 0.94A 1fm6D-4yioA:
undetectable		 1fm6D-4yioA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 1v54A-4yioA:
undetectable
1v54C-4yioA:
undetectable		 1v54A-4yioA:
17.68
1v54C-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 1v54N-4yioA:
undetectable
1v54P-4yioA:
undetectable		 1v54N-4yioA:
17.68
1v54P-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 1v55A-4yioA:
undetectable
1v55C-4yioA:
undetectable		 1v55A-4yioA:
17.68
1v55C-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 12 GLY A  74
GLY A  76
ASN A  73
LEU A  70
ILE A  62
 None
 1.01A 1zq9B-4yioA:
undetectable		 1zq9B-4yioA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 12 SER A 126
GLN A 147
LEU A  87
HIS A  80
ALA A 167
 None
None
None
FE  A 301 (-3.3A)
FE  A 301 ( 4.9A)
 1.06A 2bxcA-4yioA:
undetectable		 2bxcA-4yioA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 2dyrA-4yioA:
undetectable
2dyrC-4yioA:
undetectable		 2dyrA-4yioA:
17.68
2dyrC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 2dyrN-4yioA:
undetectable
2dyrP-4yioA:
undetectable		 2dyrN-4yioA:
17.68
2dyrP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 2dysA-4yioA:
undetectable
2dysC-4yioA:
undetectable		 2dysA-4yioA:
17.68
2dysC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.44A 2dysN-4yioA:
undetectable
2dysP-4yioA:
undetectable		 2dysN-4yioA:
17.68
2dysP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 2eijA-4yioA:
undetectable
2eijC-4yioA:
undetectable		 2eijA-4yioA:
17.68
2eijC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 2eijN-4yioA:
1.4
2eijP-4yioA:
undetectable		 2eijN-4yioA:
17.68
2eijP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 2eikA-4yioA:
undetectable
2eikC-4yioA:
undetectable		 2eikA-4yioA:
17.68
2eikC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 2eikN-4yioA:
1.4
2eikP-4yioA:
undetectable		 2eikN-4yioA:
17.68
2eikP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 2eilA-4yioA:
undetectable
2eilC-4yioA:
undetectable		 2eilA-4yioA:
17.68
2eilC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 2eilN-4yioA:
undetectable
2eilP-4yioA:
undetectable		 2eilN-4yioA:
17.68
2eilP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.44A 2eimA-4yioA:
undetectable
2eimC-4yioA:
undetectable		 2eimA-4yioA:
17.68
2eimC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.49A 2eimN-4yioA:
undetectable
2eimP-4yioA:
undetectable		 2eimN-4yioA:
17.68
2eimP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.46A 2einA-4yioA:
undetectable
2einC-4yioA:
undetectable		 2einA-4yioA:
17.68
2einC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 2einN-4yioA:
1.5
2einP-4yioA:
undetectable		 2einN-4yioA:
17.68
2einP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 7 THR A 149
PRO A 150
SER A 152
GLU A  53
PRO A 157
 None
 1.29A 2v2gA-4yioA:
undetectable
2v2gB-4yioA:
undetectable		 2v2gA-4yioA:
21.96
2v2gB-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 7 PRO A 157
THR A 149
PRO A 150
SER A 152
GLU A  53
 None
 1.28A 2v2gA-4yioA:
undetectable
2v2gB-4yioA:
undetectable		 2v2gA-4yioA:
21.96
2v2gB-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 7 THR A 149
PRO A 150
SER A 152
GLU A  53
PRO A 157
 None
 1.27A 2v2gC-4yioA:
undetectable
2v2gD-4yioA:
undetectable		 2v2gC-4yioA:
21.96
2v2gD-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 7 PRO A 157
THR A 149
PRO A 150
SER A 152
GLU A  53
 None
 1.30A 2v2gC-4yioA:
undetectable
2v2gD-4yioA:
undetectable		 2v2gC-4yioA:
21.96
2v2gD-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 8 THR A 149
PRO A 150
SER A 152
GLU A  53
PRO A 157
 None
 1.22A 2v32A-4yioA:
undetectable
2v32B-4yioA:
undetectable		 2v32A-4yioA:
21.96
2v32B-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 8 PRO A 157
THR A 149
PRO A 150
SER A 152
GLU A  53
 None
 1.28A 2v32A-4yioA:
undetectable
2v32B-4yioA:
undetectable		 2v32A-4yioA:
21.96
2v32B-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 8 THR A 149
PRO A 150
SER A 152
GLU A  53
PRO A 157
 None
 1.31A 2v32C-4yioA:
undetectable
2v32D-4yioA:
undetectable		 2v32C-4yioA:
21.96
2v32D-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 8 PRO A 157
THR A 149
PRO A 150
SER A 152
GLU A  53
 None
 1.28A 2v32C-4yioA:
undetectable
2v32D-4yioA:
undetectable		 2v32C-4yioA:
21.96
2v32D-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 9 THR A 149
PRO A 150
SER A 152
GLU A  53
PRO A 157
 None
 1.33A 2v41A-4yioA:
undetectable
2v41B-4yioA:
undetectable		 2v41A-4yioA:
21.96
2v41B-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 9 PRO A 157
THR A 149
PRO A 150
SER A 152
GLU A  53
 None
 1.28A 2v41A-4yioA:
undetectable
2v41B-4yioA:
undetectable		 2v41A-4yioA:
21.96
2v41B-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 8 THR A 149
PRO A 150
SER A 152
GLU A  53
PRO A 157
 None
 1.29A 2v41C-4yioA:
undetectable
2v41D-4yioA:
undetectable		 2v41C-4yioA:
21.96
2v41D-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 8 PRO A 157
THR A 149
PRO A 150
SER A 152
GLU A  53
 None
 1.37A 2v41C-4yioA:
undetectable
2v41D-4yioA:
undetectable		 2v41C-4yioA:
21.96
2v41D-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 7 THR A 149
PRO A 150
SER A 152
GLU A  53
PRO A 157
 None
 1.22A 2v41E-4yioA:
undetectable
2v41F-4yioA:
undetectable		 2v41E-4yioA:
21.96
2v41F-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 7 PRO A 157
THR A 149
PRO A 150
SER A 152
GLU A  53
 None
 1.36A 2v41E-4yioA:
undetectable
2v41F-4yioA:
undetectable		 2v41E-4yioA:
21.96
2v41F-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 8 THR A 149
PRO A 150
SER A 152
GLU A  53
PRO A 157
 None
 1.27A 2v41G-4yioA:
undetectable
2v41H-4yioA:
undetectable		 2v41G-4yioA:
21.96
2v41H-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 8 PRO A 157
THR A 149
PRO A 150
SER A 152
GLU A  53
 None
 1.30A 2v41G-4yioA:
undetectable
2v41H-4yioA:
undetectable		 2v41G-4yioA:
21.96
2v41H-4yioA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 10 THR A 144
VAL A 142
PHE A 116
VAL A 163
GLY A 127
 None
 1.36A 2x2iD-4yioA:
undetectable		 2x2iD-4yioA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 2y69A-4yioA:
undetectable
2y69C-4yioA:
undetectable		 2y69A-4yioA:
17.68
2y69C-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 2zxwA-4yioA:
1.4
2zxwC-4yioA:
undetectable		 2zxwA-4yioA:
17.68
2zxwC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 2zxwN-4yioA:
undetectable
2zxwP-4yioA:
undetectable		 2zxwN-4yioA:
17.68
2zxwP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.50A 3abkA-4yioA:
undetectable
3abkC-4yioA:
undetectable		 3abkA-4yioA:
17.68
3abkC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.46A 3abkN-4yioA:
undetectable
3abkP-4yioA:
undetectable		 3abkN-4yioA:
17.68
3abkP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 3abmN-4yioA:
undetectable
3abmP-4yioA:
undetectable		 3abmN-4yioA:
17.68
3abmP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.49A 3ag1A-4yioA:
1.5
3ag1C-4yioA:
undetectable		 3ag1A-4yioA:
17.68
3ag1C-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 3ag1N-4yioA:
1.4
3ag1P-4yioA:
undetectable		 3ag1N-4yioA:
17.68
3ag1P-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.49A 3ag2A-4yioA:
undetectable
3ag2C-4yioA:
undetectable		 3ag2A-4yioA:
17.68
3ag2C-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 3ag2N-4yioA:
undetectable
3ag2P-4yioA:
undetectable		 3ag2N-4yioA:
17.68
3ag2P-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 3ag3A-4yioA:
undetectable
3ag3C-4yioA:
undetectable		 3ag3A-4yioA:
17.68
3ag3C-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 3ag3N-4yioA:
1.8
3ag3P-4yioA:
undetectable		 3ag3N-4yioA:
17.68
3ag3P-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 3ag4A-4yioA:
undetectable
3ag4C-4yioA:
undetectable		 3ag4A-4yioA:
17.68
3ag4C-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 3ag4N-4yioA:
undetectable
3ag4P-4yioA:
undetectable		 3ag4N-4yioA:
17.68
3ag4P-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.49A 3asnA-4yioA:
1.5
3asnC-4yioA:
undetectable		 3asnA-4yioA:
17.68
3asnC-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		3 / 3 GLU A  85
HIS A  80
HIS A  77
 None
FE  A 301 (-3.3A)
None
 0.77A 3co4A-4yioA:
undetectable		 3co4A-4yioA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 12 HIS A  31
GLY A  75
GLY A  74
LEU A  55
ALA A  81
 None
 1.19A 3i5uA-4yioA:
undetectable		 3i5uA-4yioA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 12 HIS A  31
GLY A  75
GLY A  74
LEU A  55
ALA A  81
 None
 1.19A 3i5uB-4yioA:
undetectable		 3i5uB-4yioA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.49A 5b1aN-4yioA:
1.7
5b1aP-4yioA:
undetectable		 5b1aN-4yioA:
17.68
5b1aP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.47A 5b1bN-4yioA:
undetectable
5b1bP-4yioA:
undetectable		 5b1bN-4yioA:
17.68
5b1bP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.49A 5iy5A-4yioA:
undetectable
5iy5C-4yioA:
undetectable		 5iy5A-4yioA:
17.68
5iy5C-4yioA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMX_B_RBFB202_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 10 LEU A  86
TRP A 130
GLY A  75
HIS A  77
TRP A 128
 None
 1.48A 5umxA-4yioA:
0.0
5umxB-4yioA:
0.0		 5umxA-4yioA:
14.75
5umxB-4yioA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.48A 5x19N-4yioA:
1.6
5x19P-4yioA:
undetectable		 5x19N-4yioA:
17.68
5x19P-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.50A 5x1fN-4yioA:
undetectable
5x1fP-4yioA:
undetectable		 5x1fN-4yioA:
17.68
5x1fP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.50A 5zcqN-4yioA:
undetectable
5zcqP-4yioA:
undetectable		 5zcqN-4yioA:
17.68
5zcqP-4yioA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 11 VAL A  98
THR A  95
VAL A 141
LEU A 131
PHE A 109
 None
 1.25A 6dryA-4yioA:
undetectable		 6dryA-4yioA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		3 / 3 HIS A  80
ASN A  79
LEU A  78
 FE  A 301 (-3.3A)
None
None
 0.88A 6f7lB-4yioA:
undetectable		 6f7lB-4yioA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 11 ALA A  38
ALA A  69
ALA A  41
GLY A  76
GLY A  75
 None
 0.87A 6hwdK-4yioA:
undetectable
6hwdL-4yioA:
undetectable		 6hwdK-4yioA:
16.76
6hwdL-4yioA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		5 / 11 ALA A  38
ALA A  69
ALA A  41
GLY A  76
GLY A  75
 None
 0.88A 6hwdY-4yioA:
undetectable
6hwdZ-4yioA:
undetectable		 6hwdY-4yioA:
16.76
6hwdZ-4yioA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yio SUPEROXIDE DISMUTASE
(Streptococcus
thermophilus) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 FE  A 301 (-3.3A)
GOL  A 308 (-2.3A)
None
None
 1.49A 6nknA-4yioA:
1.5
6nknC-4yioA:
undetectable		 6nknA-4yioA:
17.68
6nknC-4yioA:
18.87