SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 12 PHE A 180
ALA A 174
GLY A 201
LEU A 211
PHE A 252
 None
 1.18A 1brpA-4yisA:
undetectable		 1brpA-4yisA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 6 PHE A 242
ILE A 249
LYS A 270
ALA A 273
 None
 1.14A 1hk2A-4yisA:
undetectable		 1hk2A-4yisA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 7 GLN A  74
LEU A  11
SER A  15
SER A  20
 None
 1.21A 1ig3A-4yisA:
undetectable
1ig3B-4yisA:
undetectable		 1ig3A-4yisA:
19.74
1ig3B-4yisA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 9 ALA A 174
GLY A  13
THR A  97
LEU A 211
LEU A 215
 None
 1.10A 1nr6A-4yisA:
undetectable		 1nr6A-4yisA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 11 THR A  33
TYR A  31
GLU A 117
LEU A 127
ILE A  37
 None
 1.40A 1t6zB-4yisA:
undetectable		 1t6zB-4yisA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 4 LYS A 108
LEU A 105
LEU A 134
SER A  22
 None
 1.47A 1tt6A-4yisA:
undetectable		 1tt6A-4yisA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 8 LEU A 134
LEU A 105
LYS A 108
ALA A 109
 None
 0.77A 2wekA-4yisA:
undetectable		 2wekA-4yisA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 12 LEU A 105
ILE A  86
LEU A  60
ILE A  56
PHE A  41
 None
 0.98A 2ygnA-4yisA:
undetectable		 2ygnA-4yisA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 12 LEU A  45
ILE A  56
LEU A  60
PHE A  90
PHE A  21
 None
 1.14A 2ygpA-4yisA:
undetectable		 2ygpA-4yisA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 4 ASP A 177
SER A 175
PHE A  14
SER A  20
 CA  A 301 ( 2.3A)
None
None
None
 1.38A 3i5uA-4yisA:
undetectable		 3i5uA-4yisA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		3 / 3 LEU A  95
TRP A 169
GLY A 172
 None
 0.80A 3l35A-4yisA:
undetectable
3l35H-4yisA:
undetectable		 3l35A-4yisA:
10.69
3l35H-4yisA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		3 / 3 LEU A  95
TRP A 169
GLY A 172
 None
 0.81A 3l35B-4yisA:
undetectable
3l35K-4yisA:
undetectable		 3l35B-4yisA:
10.69
3l35K-4yisA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 6 LEU A  11
PHE A  41
ALA A  42
LEU A  53
 None
 0.85A 3t3zA-4yisA:
undetectable		 3t3zA-4yisA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 6 LEU A  11
PHE A  41
ALA A  42
LEU A  53
 None
 0.84A 3t3zB-4yisA:
undetectable		 3t3zB-4yisA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 6 LEU A  11
PHE A  41
ALA A  42
LEU A  53
 None
 0.84A 3t3zD-4yisA:
undetectable		 3t3zD-4yisA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 11 ILE A 202
PHE A 252
ILE A 164
ALA A 174
VAL A  96
 None
 1.18A 4h1nA-4yisA:
undetectable		 4h1nA-4yisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 7 ILE A  25
LEU A 142
GLY A 129
LYS A 126
 None
 1.01A 4z69A-4yisA:
2.6		 4z69A-4yisA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 12 GLY A 172
LEU A  52
GLY A  44
PHE A 180
ILE A 258
 None
 1.18A 5tuiB-4yisA:
undetectable		 5tuiB-4yisA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 8 PHE A  75
SER A  15
HIS A  89
LEU A  60
 None
 0.89A 5y2tB-4yisA:
undetectable		 5y2tB-4yisA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		4 / 8 THR A  97
GLN A 100
THR A 104
LYS A 108
 None
 1.15A 6c06C-4yisA:
undetectable		 6c06C-4yisA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 12 LEU A  45
LEU A  52
GLY A 176
LYS A  48
LYS A  47
 None
None
CA  A 302 (-3.9A)
None
None
 1.04A 6ce2B-4yisA:
undetectable		 6ce2B-4yisA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 9 SER A 178
GLY A 201
ILE A 202
PHE A 237
ILE A 258
 None
 1.24A 6ebpA-4yisA:
undetectable		 6ebpA-4yisA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 10 SER A 178
GLY A 201
ILE A 202
PHE A 237
ILE A 258
 None
 1.24A 6ebpB-4yisA:
undetectable		 6ebpB-4yisA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4yis MEGANUCLEASE I-CPAMI
(Cryphonectria
parasitica) 		5 / 10 SER A 178
GLY A 201
ILE A 202
PHE A 237
ILE A 258
 None
 1.23A 6ebpC-4yisA:
undetectable		 6ebpC-4yisA:
15.00