SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4yit MEGANUCLEASE I-AABMI
(Gremmeniella
abietina) 		3 / 3 PHE A 211
PHE A 239
PHE A 240
 None
 0.84A 2od9A-4yitA:
undetectable		 2od9A-4yitA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4yit MEGANUCLEASE I-AABMI
(Gremmeniella
abietina) 		3 / 3 PHE A 211
PHE A 239
PHE A 240
 None
 0.84A 2qqgA-4yitA:
undetectable		 2qqgA-4yitA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4yit MEGANUCLEASE I-AABMI
(Gremmeniella
abietina) 		5 / 10 ILE A 156
GLY A   8
GLY A 164
SER A 163
PHE A 239
 None
 1.28A 4bwlC-4yitA:
undetectable		 4bwlC-4yitA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4yit MEGANUCLEASE I-AABMI
(Gremmeniella
abietina) 		3 / 3 ARG A  44
LYS A  51
TYR A  69
 None
 1.31A 6gnaA-4yitA:
undetectable		 6gnaA-4yitA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4yit MEGANUCLEASE I-AABMI
(Gremmeniella
abietina) 		3 / 3 ARG A  44
LYS A  51
TYR A  69
 None
 1.31A 6gnbA-4yitA:
undetectable		 6gnbA-4yitA:
20.77