SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yiv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 8 ASP A 106
ASP A 205
TYR A 230
THR A 211
 None
 1.36A 1ceaA-4yivA:
undetectable
1ceaB-4yivA:
undetectable		 1ceaA-4yivA:
11.41
1ceaB-4yivA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 4 GLY A 297
ASP A 392
GLY A 302
THR A 457
 None
 1.05A 1hxbB-4yivA:
undetectable		 1hxbB-4yivA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		3 / 3 SER A  93
GLY A  94
ARG A 111
 None
None
CO  A 506 ( 4.9A)
 0.69A 1t9wA-4yivA:
undetectable		 1t9wA-4yivA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		3 / 3 PHE A  85
ARG A 369
ASN A 370
 None
 0.86A 1xzxX-4yivA:
undetectable		 1xzxX-4yivA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 5 ASP A 280
SER A 188
LEU A 191
GLY A 192
 None
 1.12A 2j2pA-4yivA:
undetectable
2j2pB-4yivA:
undetectable		 2j2pA-4yivA:
20.59
2j2pB-4yivA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		5 / 12 GLY A 366
GLY A  94
ALA A 114
VAL A 334
ASP A 388
 None
 1.08A 2yvlD-4yivA:
undetectable		 2yvlD-4yivA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 8 GLY A 372
TYR A 374
SER A 402
TYR A 403
 None
 0.79A 3u9hA-4yivA:
undetectable		 3u9hA-4yivA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 8 GLY A 372
TYR A 374
SER A 402
TYR A 403
 None
 0.77A 3u9hB-4yivA:
undetectable		 3u9hB-4yivA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 8 GLY A 372
TYR A 374
SER A 402
TYR A 403
 None
 0.81A 4bjcA-4yivA:
undetectable		 4bjcA-4yivA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 7 GLY A 372
TYR A 374
SER A 402
TYR A 403
 None
 0.76A 4hyfA-4yivA:
undetectable		 4hyfA-4yivA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 8 GLY A 372
TYR A 374
SER A 402
TYR A 403
 None
 0.79A 4hyfB-4yivA:
undetectable		 4hyfB-4yivA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 8 GLY A 372
TYR A 374
SER A 402
TYR A 403
 None
 0.79A 4hyfC-4yivA:
undetectable		 4hyfC-4yivA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		3 / 3 GLU A 125
TYR A  96
GLU A 330
 None
 0.80A 4ryaA-4yivA:
undetectable		 4ryaA-4yivA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 6 PHE A 256
LEU A 155
ASN A 153
PRO A 154
 None
 1.19A 4yv5B-4yivA:
undetectable		 4yv5B-4yivA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 6 PHE A 256
LEU A 155
ASN A 153
PRO A 154
 None
 1.19A 4yv5A-4yivA:
undetectable		 4yv5A-4yivA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		4 / 5 HIS A  91
ALA A 114
SER A  93
GLY A  94
 None
 1.17A 5yodD-4yivA:
undetectable		 5yodD-4yivA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		5 / 12 ALA A 195
GLY A 115
ASP A 190
ARG A 193
PRO A 279
 None
 1.18A 5zvgA-4yivA:
undetectable		 5zvgA-4yivA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4yiv APICAL MEMBRANE
ANTIGEN AMA1
(Toxoplasma
gondii) 		5 / 12 ALA A 195
GLY A 115
ASP A 190
ARG A 193
PRO A 279
 None
 1.19A 5zvgB-4yivA:
undetectable		 5zvgB-4yivA:
21.26