SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yj1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 LEU A  72
ILE A 207
GLY A 205
ALA A 206
LEU A 194
 None
 1.01A 1cqeA-4yj1A:
undetectable		 1cqeA-4yj1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 LEU A  72
ILE A 207
GLY A 205
ALA A 206
LEU A 194
 None
 1.01A 1cqeB-4yj1A:
undetectable		 1cqeB-4yj1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 LEU A  72
ILE A 207
GLY A 205
ALA A 206
LEU A 194
 None
 1.01A 1eqhA-4yj1A:
0.8		 1eqhA-4yj1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 LEU A  72
ILE A 207
GLY A 205
ALA A 206
LEU A 194
 None
 0.98A 1eqhB-4yj1A:
undetectable		 1eqhB-4yj1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 7 THR A 169
SER A 168
TYR A 143
LEU A 217
 None
 0.89A 1ibgL-4yj1A:
undetectable		 1ibgL-4yj1A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 5 SER A 168
THR A 169
PHE A 642
GLU A 630
 None
 1.18A 1icrA-4yj1A:
undetectable
1icrB-4yj1A:
undetectable		 1icrA-4yj1A:
14.94
1icrB-4yj1A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 5 GLU A 630
SER A 168
THR A 169
PHE A 642
 None
 1.19A 1icrA-4yj1A:
undetectable
1icrB-4yj1A:
undetectable		 1icrA-4yj1A:
14.94
1icrB-4yj1A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 6 GLU A 630
SER A 168
THR A 169
PHE A 642
 None
 1.15A 1icuA-4yj1A:
undetectable
1icuB-4yj1A:
undetectable		 1icuA-4yj1A:
14.94
1icuB-4yj1A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 5 SER A 168
THR A 169
PHE A 189
GLU A 630
 None
 1.29A 1icvC-4yj1A:
undetectable
1icvD-4yj1A:
undetectable		 1icvC-4yj1A:
14.94
1icvD-4yj1A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 5 SER A 168
THR A 169
PHE A 642
GLU A 630
 None
 1.20A 1icvC-4yj1A:
undetectable
1icvD-4yj1A:
undetectable		 1icvC-4yj1A:
14.94
1icvD-4yj1A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 5 GLU A 630
SER A 168
THR A 169
PHE A 189
 None
 1.28A 1icvC-4yj1A:
undetectable
1icvD-4yj1A:
undetectable		 1icvC-4yj1A:
14.94
1icvD-4yj1A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 5 GLU A 630
SER A 168
THR A 169
PHE A 642
 None
 1.14A 1icvC-4yj1A:
undetectable
1icvD-4yj1A:
undetectable		 1icvC-4yj1A:
14.94
1icvD-4yj1A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 5 GLU A 630
SER A 168
THR A 169
PHE A 642
 None
 1.23A 1kqbA-4yj1A:
undetectable
1kqbB-4yj1A:
undetectable		 1kqbA-4yj1A:
16.75
1kqbB-4yj1A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 6 SER A 168
THR A 169
PHE A 642
GLU A 630
 None
 1.16A 1kqbC-4yj1A:
undetectable
1kqbD-4yj1A:
undetectable		 1kqbC-4yj1A:
16.75
1kqbD-4yj1A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 8 ASP A 363
PHE A 380
ASN A 378
LEU A 417
 None
 1.10A 1lhvA-4yj1A:
undetectable		 1lhvA-4yj1A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 7 LEU A 247
ASP A 345
LEU A 405
ILE A 330
 None
 1.02A 1n13I-4yj1A:
undetectable
1n13L-4yj1A:
undetectable		 1n13I-4yj1A:
9.40
1n13L-4yj1A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 PHE A 280
LEU A 322
LEU A 304
LEU A 286
PRO A 283
 None
 1.19A 1p33A-4yj1A:
undetectable		 1p33A-4yj1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 4 VAL A 234
ALA A 131
LEU A 225
PHE A 134
 None
 1.08A 1q97B-4yj1A:
3.0		 1q97B-4yj1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 11 VAL A 256
PHE A 280
THR A 309
ILE A 311
LEU A 322
 None
 0.94A 1z11A-4yj1A:
undetectable		 1z11A-4yj1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 11 VAL A 256
PHE A 280
THR A 309
ILE A 311
LEU A 322
 None
 0.93A 1z11B-4yj1A:
undetectable		 1z11B-4yj1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 LEU A  72
ILE A 207
GLY A 205
ALA A 206
LEU A 194
 None
 0.98A 2aylB-4yj1A:
undetectable		 2aylB-4yj1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 10 SER A 320
ASP A 409
ASP A 411
THR A 412
LYS A 350
 ADP  A 701 ( 2.4A)
MG  A 702 ( 4.3A)
MG  A 702 ( 4.2A)
None
None
 1.50A 2j1gE-4yj1A:
undetectable
2j1gF-4yj1A:
undetectable		 2j1gE-4yj1A:
15.26
2j1gF-4yj1A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 10 SER A 320
ASP A 411
THR A 412
GLU A 556
LYS A 350
 ADP  A 701 ( 2.4A)
MG  A 702 ( 4.2A)
None
None
None
 1.41A 2j1gE-4yj1A:
undetectable
2j1gF-4yj1A:
undetectable		 2j1gE-4yj1A:
15.26
2j1gF-4yj1A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 4 LEU A 115
THR A 117
ILE A 235
HIS A 238
 None
 1.35A 2jfaB-4yj1A:
undetectable		 2jfaB-4yj1A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 7 LEU A 247
ASP A 345
LEU A 405
ILE A 330
 None
 1.06A 2qqdA-4yj1A:
undetectable
2qqdE-4yj1A:
undetectable		 2qqdA-4yj1A:
6.17
2qqdE-4yj1A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		3 / 3 SER A 320
GLU A 556
ASP A 411
 ADP  A 701 ( 2.4A)
None
MG  A 702 ( 4.2A)
 0.73A 2zthA-4yj1A:
undetectable		 2zthA-4yj1A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		3 / 3 SER A 320
GLU A 556
ASP A 411
 ADP  A 701 ( 2.4A)
None
MG  A 702 ( 4.2A)
 0.79A 3bwmA-4yj1A:
undetectable		 3bwmA-4yj1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		3 / 3 SER A 320
GLU A 556
ASP A 411
 ADP  A 701 ( 2.4A)
None
MG  A 702 ( 4.2A)
 0.79A 3bwyA-4yj1A:
undetectable		 3bwyA-4yj1A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 4 VAL A 222
ARG A 102
ILE A  79
THR A 108
 None
 1.31A 3cl9A-4yj1A:
undetectable		 3cl9A-4yj1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 11 GLY A 619
ALA A 618
ILE A 649
GLY A 652
LEU A 655
 None
 0.94A 3em4A-4yj1A:
undetectable		 3em4A-4yj1A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 11 GLY A 619
ALA A 618
ILE A 649
GLY A 652
LEU A 655
 None
 0.81A 3em4U-4yj1A:
undetectable		 3em4U-4yj1A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		3 / 3 ASP A 444
LEU A 445
GLN A 404
 None
 0.76A 3g4lA-4yj1A:
undetectable		 3g4lA-4yj1A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 6 LEU A 136
SER A 138
PHE A 139
ILE A 188
 None
 1.00A 3ko0B-4yj1A:
undetectable		 3ko0B-4yj1A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 6 VAL A 362
VAL A 511
PHE A 609
GLU A 397
 None
 1.35A 3n61A-4yj1A:
undetectable
3n61B-4yj1A:
undetectable		 3n61A-4yj1A:
22.75
3n61B-4yj1A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 LEU A  72
ILE A 207
GLY A 205
ALA A 206
LEU A 194
 None
 0.95A 3n8xB-4yj1A:
1.4		 3n8xB-4yj1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 6 LEU A 326
ILE A 478
MET A 302
THR A 309
 None
 0.96A 4do3B-4yj1A:
undetectable		 4do3B-4yj1A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 6 LEU A 326
LEU A 322
ILE A 478
MET A 302
 None
 0.89A 4do3B-4yj1A:
undetectable		 4do3B-4yj1A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 6 PHE A 210
ALA A 206
ALA A 154
LEU A 194
 None
 1.01A 4dtzB-4yj1A:
undetectable		 4dtzB-4yj1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 ALA A 325
ILE A 649
HIS A 648
LEU A 405
GLY A 402
 None
 1.22A 4l9qA-4yj1A:
undetectable		 4l9qA-4yj1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 ARG A 339
ALA A 645
GLU A 560
ARG A 167
ARG A 137
 None
 1.37A 4mwrA-4yj1A:
undetectable		 4mwrA-4yj1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		3 / 3 PHE A 521
THR A 586
LEU A 655
 None
 0.60A 4qztA-4yj1A:
undetectable		 4qztA-4yj1A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		3 / 3 SER A 320
GLU A 556
ASP A 411
 ADP  A 701 ( 2.4A)
None
MG  A 702 ( 4.2A)
 0.75A 4xudA-4yj1A:
undetectable		 4xudA-4yj1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 10 MET A 396
LEU A 408
SER A 403
LEU A 399
VAL A 451
 None
 1.36A 4yb6D-4yj1A:
undetectable
4yb6E-4yj1A:
undetectable		 4yb6D-4yj1A:
20.10
4yb6E-4yj1A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 VAL A  61
ILE A 207
LEU A 214
CYH A  85
ALA A 154
 None
 1.27A 5fctB-4yj1A:
undetectable		 5fctB-4yj1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		3 / 3 ARG A 606
THR A 347
ASP A 345
 None
 0.95A 5g5gA-4yj1A:
undetectable
5g5gB-4yj1A:
undetectable		 5g5gA-4yj1A:
16.89
5g5gB-4yj1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 6 VAL A 234
HIS A 231
LEU A 230
LEU A 115
 None
 1.17A 5hrqB-4yj1A:
undetectable
5hrqI-4yj1A:
undetectable
5hrqJ-4yj1A:
undetectable		 5hrqB-4yj1A:
5.27
5hrqI-4yj1A:
3.11
5hrqJ-4yj1A:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 5 ASP A 626
HIS A 625
GLY A 619
ALA A 618
 None
 1.00A 5hwaA-4yj1A:
undetectable		 5hwaA-4yj1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		3 / 3 ARG A 191
PRO A 639
ASN A 565
 None
 0.96A 5jwaA-4yj1A:
undetectable
5jwaH-4yj1A:
undetectable		 5jwaA-4yj1A:
20.69
5jwaH-4yj1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 ARG A 339
ALA A 645
GLU A 560
ARG A 167
ARG A 137
 None
 1.38A 5l17A-4yj1A:
undetectable		 5l17A-4yj1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		5 / 12 LEU A 304
GLY A 307
SER A 452
LEU A 408
LEU A 406
 None
 1.08A 5nwvA-4yj1A:
undetectable		 5nwvA-4yj1A:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 6 ARG A 127
ARG A 128
PHE A 134
ILE A 186
 None
 1.02A 5vceA-4yj1A:
undetectable		 5vceA-4yj1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 8 GLY A 599
ARG A 137
VAL A 129
ASP A 133
 None
 0.92A 5vlmA-4yj1A:
undetectable		 5vlmA-4yj1A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		4 / 8 ILE A 649
ARG A 647
GLN A 563
VAL A 555
 None
 1.03A 5vlmF-4yj1A:
undetectable		 5vlmF-4yj1A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4yj1 UNCHARACTERIZED
PROTEIN
(Trypanosoma
brucei) 		3 / 3 ARG A 137
HIS A 140
ARG A 144
 None
 1.09A 6dwdD-4yj1A:
undetectable		 6dwdD-4yj1A:
21.92