SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yj5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 9 VAL A 509
GLY A 426
ALA A 427
PHE A 470
ILE A 451
 None
None
None
SER  A 603 (-4.3A)
None
 0.97A 1cetA-4yj5A:
3.0		 1cetA-4yj5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		4 / 8 PHE A 280
GLY A 276
ARG A 279
VAL A 251
 None
 0.99A 1gsfC-4yj5A:
undetectable		 1gsfC-4yj5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		4 / 4 LEU A 297
VAL A 292
CYH A 326
ALA A 351
 None
 1.19A 1mz9E-4yj5A:
undetectable		 1mz9E-4yj5A:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 ILE A 156
GLU A 154
VAL A 132
LEU A 203
ALA A 138
 None
 1.26A 2jj8C-4yj5A:
undetectable		 2jj8C-4yj5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		4 / 6 PRO A  53
HIS A  78
ASP A 228
TYR A  83
 None
 1.08A 2lh8A-4yj5A:
undetectable		 2lh8A-4yj5A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 10 THR A 454
LEU A 512
GLY A 514
GLY A 520
THR A 432
 None
 1.27A 2wd9C-4yj5A:
undetectable		 2wd9C-4yj5A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		4 / 7 PRO A  53
SER A  55
ILE A  51
GLY A 363
 None
 0.99A 2y7kA-4yj5A:
undetectable		 2y7kA-4yj5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 9 ARG A  43
ALA A 442
LEU A 465
PRO A 471
ILE A 450
 SER  A 603 (-3.9A)
None
None
SER  A 603 (-4.5A)
None
 1.09A 3em4B-4yj5A:
undetectable		 3em4B-4yj5A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		4 / 7 GLN A 329
GLY A 298
GLY A 295
ALA A 303
 None
None
PYR  A 601 (-3.3A)
None
 0.88A 3fpjB-4yj5A:
2.5		 3fpjB-4yj5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 ILE A 164
LEU A 157
LEU A 183
GLN A 184
LYS A 173
 None
 1.14A 3ix9B-4yj5A:
undetectable		 3ix9B-4yj5A:
17.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		10 / 10 THR A  50
PRO A  53
ARG A  73
ASN A  75
HIS A  78
GLY A  79
TYR A  83
GLY A 363
ALA A 366
LYS A 367
 None
None
PYR  A 601 ( 4.7A)
MG  A 602 (-3.2A)
None
None
None
None
None
None
 0.48A 3pp7B-4yj5A:
49.3		 3pp7B-4yj5A:
49.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 THR A 513
LEU A 431
VAL A 528
ILE A 510
VAL A 509
 None
 0.95A 4c9lA-4yj5A:
undetectable		 4c9lA-4yj5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 THR A 513
LEU A 431
VAL A 528
ILE A 510
VAL A 509
 None
 0.95A 4c9lB-4yj5A:
undetectable		 4c9lB-4yj5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 THR A 513
LEU A 431
VAL A 528
ILE A 510
VAL A 509
 None
 0.97A 4c9oB-4yj5A:
undetectable		 4c9oB-4yj5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 11 GLY A 289
GLN A 462
MET A 239
PHE A 241
ILE A 325
 None
 1.46A 4j4vA-4yj5A:
undetectable		 4j4vA-4yj5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		4 / 8 THR A 195
THR A 121
LEU A 183
VAL A 176
 None
 0.96A 4l4aA-4yj5A:
undetectable		 4l4aA-4yj5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		4 / 8 THR A 195
THR A 121
LEU A 183
VAL A 176
 None
 1.13A 4l4fA-4yj5A:
undetectable		 4l4fA-4yj5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 GLU A 253
ILE A 245
ILE A 283
SER A 287
ARG A 246
 None
 1.31A 4uroB-4yj5A:
undetectable		 4uroB-4yj5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 GLY A 189
LEU A 211
ILE A 299
GLY A 208
THR A 121
 None
 0.98A 4ze2A-4yj5A:
undetectable		 4ze2A-4yj5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		4 / 4 VAL A 511
ILE A 451
ASN A 491
VAL A 530
 None
 1.17A 5ajqA-4yj5A:
undetectable		 5ajqA-4yj5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 GLY A 189
LEU A 211
ILE A 299
GLY A 208
THR A 121
 None
 0.92A 5eskA-4yj5A:
undetectable		 5eskA-4yj5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 ALA A 327
SER A 333
THR A 341
GLU A 364
SER A 362
 PYR  A 601 ( 4.5A)
None
None
None
None
 1.24A 5hfjE-4yj5A:
undetectable		 5hfjE-4yj5A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 12 LEU A 203
VAL A 209
GLY A 208
ASP A 178
GLY A 179
 None
 1.19A 5nnaD-4yj5A:
undetectable		 5nnaD-4yj5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		3 / 3 GLU A  82
TYR A  83
ARG A  56
 None
 0.76A 5uunA-4yj5A:
undetectable		 5uunA-4yj5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 9 VAL A  71
ILE A 267
LYS A 266
ARG A  73
ASP A 113
 None
None
None
PYR  A 601 ( 4.7A)
MG  A 602 (-3.4A)
 1.27A 6c2mC-4yj5A:
undetectable		 6c2mC-4yj5A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		3 / 3 ARG A 443
LYS A 322
TYR A 466
 None
 1.10A 6gnaA-4yj5A:
undetectable		 6gnaA-4yj5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		3 / 3 ARG A 443
LYS A 322
TYR A 466
 None
 1.10A 6gnbA-4yj5A:
undetectable		 6gnbA-4yj5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 4yj5 PYRUVATE KINASE PKM
(Homo
sapiens) 		5 / 11 ASP A 296
ASN A 273
ASP A 250
GLY A 116
ASP A 225
 PYR  A 601 (-3.5A)
None
None
None
None
 1.32A 6mb5A-4yj5A:
undetectable		 6mb5A-4yj5A:
10.95