SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yjf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 LEU B 145
LEU B 148
LEU B  17
LEU B 316
THR B  43
 None
None
None
FAD  B 401 (-3.8A)
FAD  B 401 (-3.9A)
 1.41A 1a28B-4yjfB:
undetectable		 1a28B-4yjfB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		3 / 3 GLU B 304
LYS B 332
VAL B 333
 None
 0.90A 1l2iA-4yjfB:
undetectable		 1l2iA-4yjfB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		3 / 3 GLU B  64
TRP B  67
LYS B 116
 None
 1.25A 1qu2A-4yjfB:
undetectable		 1qu2A-4yjfB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 TYR B 224
GLY B 313
GLY B 315
THR B 317
ILE B 223
 98B  B 404 (-3.3A)
FAD  B 401 ( 3.5A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.7A)
None
 1.21A 2akeA-4yjfB:
undetectable		 2akeA-4yjfB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 TYR B 224
GLY B 313
GLY B 315
THR B 317
ILE B 223
 98B  B 404 (-3.3A)
FAD  B 401 ( 3.5A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.7A)
None
 1.22A 2azxA-4yjfB:
undetectable		 2azxA-4yjfB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 TYR B 224
GLY B 313
GLY B 315
THR B 317
ILE B 223
 98B  B 404 (-3.3A)
FAD  B 401 ( 3.5A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.7A)
None
 1.23A 2azxB-4yjfB:
undetectable		 2azxB-4yjfB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 11 TYR B 224
GLY B 313
GLY B 315
THR B 317
ILE B 223
 98B  B 404 (-3.3A)
FAD  B 401 ( 3.5A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.7A)
None
 1.20A 2dr2A-4yjfB:
2.3		 2dr2A-4yjfB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 THR B  44
ILE B   6
GLY B   7
GLY B   9
ALA B  36
 FAD  B 401 (-3.4A)
None
FAD  B 401 (-3.3A)
FAD  B 401 (-3.3A)
FAD  B 401 (-3.5A)
 0.92A 2fk8A-4yjfB:
undetectable		 2fk8A-4yjfB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		3 / 3 TYR B  95
GLY B 131
PHE B 133
 None
 0.66A 2m2pB-4yjfB:
undetectable		 2m2pB-4yjfB:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 GLY B  12
GLY B   7
ILE B 179
ALA B 323
THR B  43
 None
FAD  B 401 (-3.3A)
None
None
FAD  B 401 (-3.9A)
 1.27A 2vdvE-4yjfB:
3.2		 2vdvE-4yjfB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 11 GLY B  12
GLY B   7
ILE B 179
ALA B 323
THR B  43
 None
FAD  B 401 (-3.3A)
None
None
FAD  B 401 (-3.9A)
 1.27A 2vdvF-4yjfB:
3.2		 2vdvF-4yjfB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		3 / 3 PHE B 133
ASN B 134
PHE B 213
 None
 1.05A 2zbuD-4yjfB:
4.3		 2zbuD-4yjfB:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 8 ALA B   8
PHE B  39
THR B 149
LEU B 152
 FAD  B 401 (-3.8A)
None
None
None
 0.89A 3hrdA-4yjfB:
undetectable
3hrdB-4yjfB:
undetectable		 3hrdA-4yjfB:
22.46
3hrdB-4yjfB:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 5 ILE B  11
HIS B 311
VAL B 289
ASN B 308
 FAD  B 401 (-4.0A)
None
None
None
 1.28A 3nneA-4yjfB:
10.8		 3nneA-4yjfB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 6 ILE B  11
HIS B 311
VAL B 289
ASN B 308
 FAD  B 401 (-4.0A)
None
None
None
 1.21A 3nneG-4yjfB:
10.7		 3nneG-4yjfB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 TYR B  74
ALA B 323
GLY B 321
HIS B 311
SER B  14
 None
 1.25A 3pfgA-4yjfB:
3.6		 3pfgA-4yjfB:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 TYR B  74
TYR B 144
VAL B 157
LEU B  30
HIS B  24
 None
None
None
None
SO4  B 402 (-4.4A)
 1.48A 3vt7A-4yjfB:
undetectable		 3vt7A-4yjfB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 6 HIS B 217
ILE B 215
TYR B 224
ASN B 134
 None
None
98B  B 404 (-3.3A)
None
 1.49A 4o7gB-4yjfB:
undetectable		 4o7gB-4yjfB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 6 THR B 317
THR B  56
HIS B 217
ASN B 134
 FAD  B 401 (-3.7A)
None
None
None
 1.15A 4pfjB-4yjfB:
3.6		 4pfjB-4yjfB:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 9 LEU B  75
LEU B 233
THR B  90
LEU B 137
ILE B 138
 None
 1.35A 4ubsA-4yjfB:
undetectable		 4ubsA-4yjfB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD401_0
(PROTON-GATED ION
CHANNEL)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 5 PHE B 282
ARG B 199
ILE B 250
GLU B 249
 None
 1.12A 4zzcD-4yjfB:
0.3
4zzcE-4yjfB:
0.0		 4zzcD-4yjfB:
21.79
4zzcE-4yjfB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 5 GLY B 240
THR B 241
GLY B 113
LEU B  51
 None
 0.87A 5jlcA-4yjfB:
undetectable		 5jlcA-4yjfB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 GLY B 200
VAL B  10
GLY B 141
GLY B 312
VAL B 184
 FAD  B 401 ( 4.2A)
FAD  B 401 (-4.5A)
None
FAD  B 401 (-4.6A)
None
 1.06A 5tuiB-4yjfB:
13.9		 5tuiB-4yjfB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 PHE B 213
ALA B  48
TYR B 224
ALA B  49
GLY B  50
 None
FAD  B 401 (-3.6A)
98B  B 404 (-3.3A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.9A)
 1.25A 5tzoA-4yjfB:
undetectable		 5tzoA-4yjfB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 PHE B 213
ALA B  48
TYR B 224
ALA B  49
GLY B  50
 None
FAD  B 401 (-3.6A)
98B  B 404 (-3.3A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.9A)
 1.15A 5tzoB-4yjfB:
undetectable		 5tzoB-4yjfB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		5 / 12 PHE B 213
ALA B  48
TYR B 224
ALA B  49
GLY B  50
 None
FAD  B 401 (-3.6A)
98B  B 404 (-3.3A)
FAD  B 401 (-3.2A)
FAD  B 401 (-3.9A)
 1.26A 5tzoC-4yjfB:
undetectable		 5tzoC-4yjfB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 8 GLN B 288
GLY B 310
ILE B 318
TRP B  67
 None
 0.99A 5vlmH-4yjfB:
undetectable		 5vlmH-4yjfB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_2
(-)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 4 GLN B 146
THR B  40
HIS B 319
LEU B 139
 SO4  B 403 (-4.2A)
None
None
None
 1.47A 6f3nB-4yjfB:
3.9		 6f3nB-4yjfB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 8 VAL B 177
TYR B  23
GLU B 325
CYH B 322
 None
 1.25A 6gneB-4yjfB:
2.6		 6gneB-4yjfB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 4yjf D-AMINO-ACID OXIDASE
(Sus
scrofa) 		4 / 5 TYR B 128
ASN B  96
TYR B  95
PHE B 125
 None
 1.07A 6h3dA-4yjfB:
2.9		 6h3dA-4yjfB:
21.54