SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		3 / 3 THR A 131
THR A 129
PRO A 134
 None
 0.81A 1a7yB-4yk2A:
undetectable		 1a7yB-4yk2A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		5 / 12 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
 None
 0.95A 1fbyA-4yk2A:
undetectable		 1fbyA-4yk2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		5 / 12 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
 None
 0.96A 1fbyB-4yk2A:
undetectable		 1fbyB-4yk2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		5 / 12 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
 None
 0.93A 1fm6A-4yk2A:
undetectable		 1fm6A-4yk2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		5 / 12 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
 None
 0.96A 1fm9A-4yk2A:
undetectable		 1fm9A-4yk2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		3 / 3 THR A 129
PRO A 134
THR A 131
 None
 0.85A 1i3wE-4yk2A:
undetectable		 1i3wE-4yk2A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		3 / 3 THR A 129
PRO A 134
THR A 131
 None
 0.87A 1ovfB-4yk2A:
undetectable		 1ovfB-4yk2A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		3 / 3 THR A 131
THR A 129
PRO A 134
 None
 0.77A 1qfiB-4yk2A:
undetectable		 1qfiB-4yk2A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		3 / 3 THR A 131
THR A 129
PRO A 134
 None
 0.85A 1unjF-4yk2A:
undetectable		 1unjF-4yk2A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		5 / 12 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
 None
 0.88A 1xdkA-4yk2A:
undetectable		 1xdkA-4yk2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		5 / 12 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
 None
 0.88A 1xdkE-4yk2A:
undetectable		 1xdkE-4yk2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		6 / 10 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
ILE A 167
 None
 1.45A 3falC-4yk2A:
undetectable		 3falC-4yk2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		6 / 11 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
ILE A 167
 None
 1.39A 3fc6A-4yk2A:
undetectable		 3fc6A-4yk2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		4 / 5 LYS A 162
SER A 127
LEU A  98
SER A  99
 None
 1.47A 3ijxH-4yk2A:
undetectable		 3ijxH-4yk2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		4 / 6 GLU A  92
ARG A  96
LEU A 113
TYR A 170
 None
 0.77A 5phhA-4yk2A:
undetectable		 5phhA-4yk2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		5 / 12 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
 None
 0.98A 5uanA-4yk2A:
undetectable		 5uanA-4yk2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		5 / 12 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
 None
 0.87A 5z12B-4yk2A:
undetectable		 5z12B-4yk2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
(Bartonella
clarridgeiae) 		6 / 12 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
ILE A 167
 None
 1.48A 6a5yD-4yk2A:
undetectable		 6a5yD-4yk2A:
19.05