SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4yk3 BEPE PROTEIN
(Bartonella
henselae) 		5 / 12 GLN A 244
LEU A 235
ASP A 193
ALA A 245
VAL A 184
 None
 1.32A 2g70A-4yk3A:
undetectable		 2g70A-4yk3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4yk3 BEPE PROTEIN
(Bartonella
henselae) 		5 / 12 GLN A 244
LEU A 235
ASP A 193
ALA A 245
VAL A 184
 None
 1.30A 2g70B-4yk3A:
undetectable		 2g70B-4yk3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4yk3 BEPE PROTEIN
(Bartonella
henselae) 		3 / 3 LYS A 187
PRO A 188
SER A 189
 None
 0.47A 4k50I-4yk3A:
undetectable		 4k50I-4yk3A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4yk3 BEPE PROTEIN
(Bartonella
henselae) 		4 / 7 CYH A 167
HIS A 230
LEU A 231
ALA A 234
 None
 0.66A 5hrqE-4yk3A:
undetectable
5hrqF-4yk3A:
undetectable
5hrqJ-4yk3A:
undetectable		 5hrqE-4yk3A:
11.22
5hrqF-4yk3A:
13.01
5hrqJ-4yk3A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4yk3 BEPE PROTEIN
(Bartonella
henselae) 		4 / 6 HIS A 165
CYH A 167
HIS A 230
LEU A 231
 None
 1.33A 5hrqD-4yk3A:
undetectable
5hrqG-4yk3A:
undetectable
5hrqH-4yk3A:
undetectable		 5hrqD-4yk3A:
13.01
5hrqG-4yk3A:
11.22
5hrqH-4yk3A:
13.01