SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		3 / 3 VAL A 450
ALA A 449
HIS A 408
 None
 0.67A 1q23G-4yk6A:
undetectable		 1q23G-4yk6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		3 / 3 VAL A 450
ALA A 449
HIS A 408
 None
 0.69A 1q23J-4yk6A:
undetectable		 1q23J-4yk6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 585
ALA A 591
LEU A 595
LEU A 616
ILE A 631
 None
 1.15A 1s9pA-4yk6A:
undetectable		 1s9pA-4yk6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 639
HIS A 668
ILE A 632
 None
 0.70A 1s9pB-4yk6A:
undetectable		 1s9pB-4yk6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 707
ALA A 723
LEU A 710
SER A 713
 None
 1.12A 1tt6B-4yk6A:
undetectable		 1tt6B-4yk6A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.94A 1v54A-4yk6A:
2.3
1v54J-4yk6A:
undetectable		 1v54A-4yk6A:
18.86
1v54J-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.92A 1v54N-4yk6A:
undetectable
1v54W-4yk6A:
undetectable		 1v54N-4yk6A:
18.86
1v54W-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.95A 2dyrA-4yk6A:
undetectable
2dyrJ-4yk6A:
undetectable		 2dyrA-4yk6A:
18.86
2dyrJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.94A 2dyrN-4yk6A:
undetectable
2dyrW-4yk6A:
undetectable		 2dyrN-4yk6A:
18.86
2dyrW-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.96A 2dysA-4yk6A:
1.0
2dysJ-4yk6A:
undetectable		 2dysA-4yk6A:
18.86
2dysJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.92A 2dysN-4yk6A:
2.1
2dysW-4yk6A:
undetectable		 2dysN-4yk6A:
18.86
2dysW-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.95A 2eijA-4yk6A:
undetectable
2eijJ-4yk6A:
undetectable		 2eijA-4yk6A:
18.86
2eijJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.93A 2eijN-4yk6A:
undetectable
2eijW-4yk6A:
undetectable		 2eijN-4yk6A:
18.86
2eijW-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.94A 2eikA-4yk6A:
undetectable
2eikJ-4yk6A:
undetectable		 2eikA-4yk6A:
18.86
2eikJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.95A 2eikN-4yk6A:
2.3
2eikW-4yk6A:
undetectable		 2eikN-4yk6A:
18.86
2eikW-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.89A 2eilA-4yk6A:
0.9
2eilJ-4yk6A:
undetectable		 2eilA-4yk6A:
18.86
2eilJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 5 ASP A 482
SER A 494
LEU A 488
GLY A 487
 None
 0.98A 2j2pA-4yk6A:
undetectable
2j2pB-4yk6A:
undetectable		 2j2pA-4yk6A:
19.44
2j2pB-4yk6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 ASP A 482
SER A 494
LEU A 488
GLY A 487
 None
 0.97A 2j2pA-4yk6A:
undetectable
2j2pC-4yk6A:
undetectable		 2j2pA-4yk6A:
19.44
2j2pC-4yk6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 ASP A 482
SER A 494
LEU A 488
GLY A 487
 None
 0.99A 2j2pD-4yk6A:
undetectable
2j2pF-4yk6A:
undetectable		 2j2pD-4yk6A:
19.44
2j2pF-4yk6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.96A 2zxwA-4yk6A:
0.9
2zxwJ-4yk6A:
undetectable		 2zxwA-4yk6A:
18.86
2zxwJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.95A 3ablA-4yk6A:
undetectable
3ablJ-4yk6A:
undetectable		 3ablA-4yk6A:
18.86
3ablJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.93A 3ablN-4yk6A:
undetectable
3ablW-4yk6A:
undetectable		 3ablN-4yk6A:
18.86
3ablW-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 1.00A 3abmA-4yk6A:
undetectable
3abmJ-4yk6A:
undetectable		 3abmA-4yk6A:
18.86
3abmJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.91A 3ag3N-4yk6A:
2.5
3ag3W-4yk6A:
undetectable		 3ag3N-4yk6A:
18.86
3ag3W-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.94A 3asnA-4yk6A:
undetectable
3asnJ-4yk6A:
undetectable		 3asnA-4yk6A:
18.86
3asnJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.94A 3asnN-4yk6A:
2.2
3asnW-4yk6A:
undetectable		 3asnN-4yk6A:
18.86
3asnW-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.93A 3asoA-4yk6A:
2.1
3asoJ-4yk6A:
undetectable		 3asoA-4yk6A:
18.86
3asoJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.00A 3pghA-4yk6A:
undetectable		 3pghA-4yk6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.01A 3pghC-4yk6A:
undetectable		 3pghC-4yk6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.04A 3rr3A-4yk6A:
undetectable		 3rr3A-4yk6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.04A 3rr3B-4yk6A:
undetectable		 3rr3B-4yk6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 635
ASN A 679
ILE A 631
GLU A 582
LEU A 592
 None
 1.21A 4azsA-4yk6A:
undetectable		 4azsA-4yk6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 11 ALA A 597
SER A 634
MET A 573
LEU A 616
VAL A 642
 None
 1.46A 4eilE-4yk6A:
undetectable		 4eilE-4yk6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.99A 5b1bA-4yk6A:
undetectable
5b1bJ-4yk6A:
undetectable		 5b1bA-4yk6A:
18.86
5b1bJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.01A 5iktA-4yk6A:
0.2		 5iktA-4yk6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.00A 5iktB-4yk6A:
0.0		 5iktB-4yk6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.95A 5iy5A-4yk6A:
undetectable
5iy5J-4yk6A:
undetectable		 5iy5A-4yk6A:
18.86
5iy5J-4yk6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 7 GLY A 618
GLY A 635
SER A 634
GLY A 636
VAL A 617
 None
 1.44A 5izjB-4yk6A:
undetectable		 5izjB-4yk6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 563
GLY A 567
LEU A 551
LEU A 519
LEU A 529
 None
 1.24A 5nfjB-4yk6A:
undetectable		 5nfjB-4yk6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 5 MET A 701
ASN A 709
VAL A 704
LEU A 698
 None
 1.35A 5xdhB-4yk6A:
undetectable		 5xdhB-4yk6A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		4 / 5 MET A 701
ASN A 709
VAL A 704
LEU A 698
 None
 1.31A 5xdhD-4yk6A:
undetectable		 5xdhD-4yk6A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 637
GLY A 635
ASN A 641
SER A 590
THR A 675
 None
 1.06A 5yf0A-4yk6A:
undetectable		 5yf0A-4yk6A:
19.28