SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 4yk8 AUTOPHAGY PROTEIN 13
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY B 247
CYH B  47
THR B  51
ILE B 255
PHE B 253
 None
 1.37A 1m2zD-4yk8B:
undetectable		 1m2zD-4yk8B:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4yk8 AUTOPHAGY PROTEIN 13
(Schizosaccharomy
ces
pombe) 		4 / 8 SER B  58
THR B  51
LEU B 174
THR B 113
 None
 0.87A 2v0zO-4yk8B:
undetectable		 2v0zO-4yk8B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4yk8 AUTOPHAGY PROTEIN 13
(Schizosaccharomy
ces
pombe) 		5 / 10 PRO B 249
LEU B 156
ILE B  44
SER B  37
GLY B  41
 None
 1.31A 3ijxB-4yk8B:
undetectable
3ijxD-4yk8B:
undetectable		 3ijxB-4yk8B:
22.42
3ijxD-4yk8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA405_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 4yk8 MEIOTICALLY
UP-REGULATED GENE 66
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 5 ARG A  31
LEU A  85
TRP A 103
ASN A   3
 None
 1.32A 4ifxA-4yk8A:
0.0		 4ifxA-4yk8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4yk8 MEIOTICALLY
UP-REGULATED GENE 66
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 6 ASN A  57
MET A  81
ILE A  41
VAL A  43
 None
 0.96A 4olmA-4yk8A:
undetectable		 4olmA-4yk8A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA408_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4yk8 MEIOTICALLY
UP-REGULATED GENE 66
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 5 ARG A  31
LEU A  85
TRP A 103
ASN A   3
 None
 1.30A 4xdtA-4yk8A:
0.0		 4xdtA-4yk8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 4yk8 MEIOTICALLY
UP-REGULATED GENE 66
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LYS A  21
ASP A  69
PHE A  67
THR A  70
THR A 110
 None
 1.48A 4z7fB-4yk8A:
undetectable		 4z7fB-4yk8A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4yk8 MEIOTICALLY
UP-REGULATED GENE 66
PROTEIN
(Schizosaccharomy
ces
pombe) 		4 / 8 GLN A 135
ILE A   7
TRP A 106
GLN A 105
 None
 1.08A 5vlmD-4yk8A:
undetectable		 5vlmD-4yk8A:
22.60