SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ykc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4ykc MALCAVERNIN
(Homo
sapiens) 		4 / 6 ILE A 428
LEU A 299
PHE A 356
GLY A 352
 None
 0.97A 3sj1X-4ykcA:
undetectable		 3sj1X-4ykcA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4ykc MALCAVERNIN
(Homo
sapiens) 		5 / 12 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.50A 5cymA-4ykcA:
undetectable		 5cymA-4ykcA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4ykc MALCAVERNIN
(Homo
sapiens) 		5 / 12 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.48A 5cyqA-4ykcA:
undetectable		 5cyqA-4ykcA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4ykc MALCAVERNIN
(Homo
sapiens) 		5 / 12 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.46A 6eliA-4ykcA:
undetectable		 6eliA-4ykcA:
15.24