SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 8 GLN A 335
LEU A 370
ARG A 306
LEU A 310
 None
 0.99A 1hk3A-4ykeA:
undetectable		 1hk3A-4ykeA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4yke MRE11
(Chaetomium
thermophilum) 		5 / 12 LEU A  76
LEU A 140
ILE A  40
PRO A  64
VAL A  20
 None
 1.39A 1hrkB-4ykeA:
undetectable		 1hrkB-4ykeA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4yke MRE11
(Chaetomium
thermophilum) 		3 / 3 ASP A  57
HIS A 125
HIS A  19
 MN  A 602 ( 2.7A)
None
MN  A 601 (-3.4A)
 0.48A 1oe1A-4ykeA:
undetectable		 1oe1A-4ykeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4yke MRE11
(Chaetomium
thermophilum) 		3 / 3 ASP A  57
HIS A 125
HIS A  19
 MN  A 602 ( 2.7A)
None
MN  A 601 (-3.4A)
 0.47A 1oe3A-4ykeA:
undetectable		 1oe3A-4ykeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4yke MRE11
(Chaetomium
thermophilum) 		3 / 3 THR A  16
GLU A 274
HIS A  60
 None
 0.64A 1xwfA-4ykeA:
undetectable		 1xwfA-4ykeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4yke MRE11
(Chaetomium
thermophilum) 		3 / 3 THR A  16
GLU A 274
HIS A  60
 None
 0.68A 1xwfB-4ykeA:
undetectable		 1xwfB-4ykeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4yke MRE11
(Chaetomium
thermophilum) 		3 / 3 THR A  16
GLU A 274
HIS A  60
 None
 0.63A 1xwfC-4ykeA:
undetectable		 1xwfC-4ykeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4yke MRE11
(Chaetomium
thermophilum) 		3 / 3 THR A  16
GLU A 274
HIS A  60
 None
 0.68A 1xwfD-4ykeA:
undetectable		 1xwfD-4ykeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 6 LEU A 270
ALA A 275
ASP A  32
TYR A  22
 None
 1.29A 2dpzA-4ykeA:
undetectable		 2dpzA-4ykeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 6 GLY A 263
PRO A 262
ILE A 238
GLY A 240
 None
 0.85A 2jkjA-4ykeA:
undetectable		 2jkjA-4ykeA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 6 GLY A 263
PRO A 262
ILE A 238
GLY A 240
 None
 0.85A 2jkjB-4ykeA:
undetectable		 2jkjB-4ykeA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 6 GLY A 263
PRO A 262
ILE A 238
GLY A 240
 None
 0.85A 2jkjC-4ykeA:
undetectable		 2jkjC-4ykeA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 6 GLY A 263
PRO A 262
ILE A 238
GLY A 240
 None
 0.84A 2jklB-4ykeA:
undetectable		 2jklB-4ykeA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4yke MRE11
(Chaetomium
thermophilum) 		3 / 3 ASP A  57
HIS A 125
HIS A  19
 MN  A 602 ( 2.7A)
None
MN  A 601 (-3.4A)
 0.49A 2xxgA-4ykeA:
undetectable		 2xxgA-4ykeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4yke MRE11
(Chaetomium
thermophilum) 		3 / 3 ASP A  57
HIS A 125
HIS A  19
 MN  A 602 ( 2.7A)
None
MN  A 601 (-3.4A)
 0.51A 2xxgC-4ykeA:
undetectable		 2xxgC-4ykeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4yke MRE11
(Chaetomium
thermophilum) 		3 / 3 HIS A  60
HIS A  19
HIS A 125
 None
MN  A 601 (-3.4A)
None
 0.85A 3mihA-4ykeA:
undetectable		 3mihA-4ykeA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 8 PHE A 390
VAL A 404
ILE A 368
GLU A 385
 None
 1.07A 4a97G-4ykeA:
undetectable		 4a97G-4ykeA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4yke MRE11
(Chaetomium
thermophilum) 		5 / 12 HIS A  19
HIS A 243
GLY A 263
ASP A  57
GLY A  56
 MN  A 601 (-3.4A)
MN  A 601 (-3.5A)
None
MN  A 602 ( 2.7A)
None
 1.28A 4bz6C-4ykeA:
undetectable		 4bz6C-4ykeA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 8 ASN A 147
PHE A  98
VAL A  97
LEU A 165
 None
 1.14A 4f5zA-4ykeA:
undetectable		 4f5zA-4ykeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4yke MRE11
(Chaetomium
thermophilum) 		5 / 12 HIS A  19
HIS A 243
GLY A 263
ASP A  57
GLY A  56
 MN  A 601 (-3.4A)
MN  A 601 (-3.5A)
None
MN  A 602 ( 2.7A)
None
 1.29A 4qa0A-4ykeA:
undetectable		 4qa0A-4ykeA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4yke MRE11
(Chaetomium
thermophilum) 		5 / 12 HIS A  19
HIS A 243
GLY A 263
ASP A  57
GLY A  56
 MN  A 601 (-3.4A)
MN  A 601 (-3.5A)
None
MN  A 602 ( 2.7A)
None
 1.29A 4qa2A-4ykeA:
undetectable		 4qa2A-4ykeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 5 GLN A 214
LEU A 212
ASP A  57
ASP A  61
 None
None
MN  A 602 ( 2.7A)
None
 1.13A 4qtuD-4ykeA:
undetectable		 4qtuD-4ykeA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 5 ILE A 266
SER A 269
HIS A 243
ASP A  61
 None
None
MN  A 601 (-3.5A)
None
 1.25A 4rzvB-4ykeA:
undetectable		 4rzvB-4ykeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 6 ASP A  57
HIS A 125
HIS A  19
HIS A 241
 MN  A 602 ( 2.7A)
None
MN  A 601 (-3.4A)
MN  A 602 (-2.9A)
 0.93A 5ncdA-4ykeA:
undetectable
5ncdD-4ykeA:
undetectable		 5ncdA-4ykeA:
18.36
5ncdD-4ykeA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 8 VAL A  72
GLY A  56
LEU A  54
THR A  16
 None
 1.09A 5sxqB-4ykeA:
undetectable		 5sxqB-4ykeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 8 VAL A  72
GLY A  56
LEU A  54
THR A  16
 None
 1.09A 5syjA-4ykeA:
undetectable		 5syjA-4ykeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4yke MRE11
(Chaetomium
thermophilum) 		4 / 4 LEU A 137
ASP A 138
GLN A 141
VAL A 237
 None
 0.87A 6bzoF-4ykeA:
undetectable		 6bzoF-4ykeA:
22.11