SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ykn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AFS_A_TESA325_1 (3-ALPHA-HYDROXYSTERO ID DEHYDROGENASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 7	LEU A1287 TYR A1250 THR A1229 TYR A1207	None	1.19A	1afsA-4yknA: undetectable	1afsA-4yknA: 12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AFS_B_TESB325_1 (3-ALPHA-HYDROXYSTERO ID DEHYDROGENASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 7	LEU A1287 TYR A1250 THR A1229 TYR A1207	None	1.18A	1afsB-4yknA: undetectable	1afsB-4yknA: 12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7F_A_BCZA801_1 (NEURAMINIDASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	ARG A1088 ARG A1704 ARG A1038	None	1.05A	1l7fA-4yknA: undetectable	1l7fA-4yknA: 13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7H_A_BCZA801_1 (NEURAMINIDASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	ARG A1088 ARG A1704 ARG A1038	None	1.05A	1l7hA-4yknA: undetectable	1l7hA-4yknA: 13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW5_A_SAMA401_1 (MODIFICATION METHYLASE RSRI)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	ASP A1915 HIS A1936 ASP A1933	None None 4EL A2101 (-4.6A)	0.89A	1nw5A-4yknA: undetectable	1nw5A-4yknA: 13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XQL_A_4AXA605_1 (ALANINE RACEMASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 8	TYR A 470 LYS A 567 TYR A 463 TYR A 467	None	1.49A	1xqlA-4yknA: undetectable 1xqlB-4yknA: undetectable	1xqlA-4yknA: 13.93 1xqlB-4yknA: 13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CIZ_A_ACTA1321_0 (CHLOROPEROXIDASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 5	LEU A1831 PHE A1980 VAL A1906 ALA A1987	None	1.16A	2cizA-4yknA: undetectable	2cizA-4yknA: 12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8L_A_SAMA400_1 (HYPOTHETICAL PROTEIN LMO1582)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 4	THR A 371 THR A 354 ASP A 352 ASP A1390	None	1.43A	2f8lA-4yknA: undetectable	2f8lA-4yknA: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OAX_D_SNLD4001_2 (MINERALOCORTICOID RECEPTOR)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 5	LEU A1956 LEU A1877 CYH A1971 THR A1972	None	1.40A	2oaxD-4yknA: undetectable	2oaxD-4yknA: 11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OPX_A_DXCA1003_0 (ALDEHYDE DEHYDROGENASE A)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 5	ILE A1393 LEU A1396 ASP A1390 ALA A1333	None	0.94A	2opxA-4yknA: undetectable	2opxA-4yknA: 16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P2F_A_ACTA653_0 (ACETYL-COENZYME A SYNTHETASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 5	THR A1679 VAL A1461 GLY A1460 TRP A1446	None	1.08A	2p2fA-4yknA: undetectable	2p2fA-4yknA: 17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QE6_A_SAMA400_1 (UNCHARACTERIZED PROTEIN TFU_2867)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	ASN A 377 ARG A 373 ASP A1454	None	1.00A	2qe6A-4yknA: undetectable	2qe6A-4yknA: 11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QE6_B_SAMB400_1 (UNCHARACTERIZED PROTEIN TFU_2867)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	ASN A 377 ARG A 373 ASP A1454	None	0.94A	2qe6B-4yknA: undetectable	2qe6B-4yknA: 11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3A_B_TOPB1189_1 (DIHYDROFOLATE REDUCTASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 10	ILE A1964 ALA A1902 PHE A1897 ILE A1857 LEU A1877	None	1.12A	2w3aB-4yknA: undetectable	2w3aB-4yknA: 9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGP_A_PCFA1213_0 (WNT INHIBITORY FACTOR 1)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 12	ILE A1391 LEU A1367 ILE A1393 VAL A1437 PHE A1430	None	1.10A	2ygpA-4yknA: undetectable	2ygpA-4yknA: 9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADX_A_IMNA2_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 7	ILE A1921 LEU A1929 PHE A1930 LEU A1814	None	0.91A	3adxA-4yknA: undetectable	3adxA-4yknA: 12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3APW_A_DP0A190_2 (ALPHA-1-ACID GLYCOPROTEIN 2)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 4	VAL A1706 ARG A1704 HIS A1701 PHE A1119	None	1.42A	3apwA-4yknA: 0.0	3apwA-4yknA: 8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_D_SAMD300_1 (PUTATIVE RRNA METHYLASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	ASN A1920 ASP A1810 GLN A1809	None	0.77A	3eeyD-4yknA: undetectable	3eeyD-4yknA: 9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JQ7_B_DX2B271_1 (PTERIDINE REDUCTASE 1)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 8	SER A 474 TYR A 470 LEU A1445 PRO A1471	None	1.21A	3jq7B-4yknA: undetectable	3jq7B-4yknA: 11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L35_H_DHIH3_0 (GP41 N-PEPTIDE HIV ENTRY INHIBITOR PIE12)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	LEU A1452 TRP A1424 GLY A1425	None	0.65A	3l35A-4yknA: undetectable 3l35H-4yknA: undetectable	3l35A-4yknA: 3.04 3l35H-4yknA: 1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L35_K_DHIK3_0 (GP41 N-PEPTIDE HIV ENTRY INHIBITOR PIE12)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	LEU A1452 TRP A1424 GLY A1425	None	0.69A	3l35B-4yknA: undetectable 3l35K-4yknA: undetectable	3l35B-4yknA: 3.04 3l35K-4yknA: 1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6D_A_SAMA1350_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 12	PHE A2016 LEU A1570 TRP A1574 GLY A1364 ASP A1603	None	0.99A	4a6dA-4yknA: undetectable	4a6dA-4yknA: 13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6E_A_SAMA1349_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 12	PHE A2016 LEU A1570 TRP A1574 GLY A1364 ASP A1603	None	1.01A	4a6eA-4yknA: undetectable	4a6eA-4yknA: 13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BBO_D_ACTD1113_0 (BLR5658 PROTEIN)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 4	TRP A1383 LEU A1473 LEU A1404 THR A1358	None	1.25A	4bboD-4yknA: undetectable	4bboD-4yknA: 6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 8	VAL A1923 TYR A1904 CYH A1901 ILE A1921	None	1.22A	4bqtC-4yknA: undetectable 4bqtD-4yknA: undetectable	4bqtC-4yknA: 10.51 4bqtD-4yknA: 10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DTA_A_ADNA401_1 (APH(2'')-ID)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 10	ILE A1816 ILE A1910 HIS A1994 LEU A2026 ILE A1991	None	1.24A	4dtaA-4yknA: 2.8	4dtaA-4yknA: 11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F4D_A_CHDA506_0 (FERROCHELATASE, MITOCHONDRIAL)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 4	PRO A1566 LEU A1570 ILE A1543 ARG A 340	None	1.39A	4f4dA-4yknA: undetectable	4f4dA-4yknA: 13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_E_ACTE502_0 (RNA POLYMERASE 3D-POL)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	ARG A1230 LYS A1228 LYS A1227	None	1.22A	4k50E-4yknA: undetectable	4k50E-4yknA: 15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KM0_B_CP6B201_1 (DIHYDROFOLATE REDUCTASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 12	ILE A1991 ALA A1907 ILE A1817 PHE A1998 ILE A1823	None	1.13A	4km0B-4yknA: undetectable	4km0B-4yknA: 8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4C_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 8	PHE A1139 LEU A1639 VAL A1146 ILE A1143	None	0.93A	4l4cB-4yknA: undetectable	4l4cB-4yknA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_2 (PROSTAGLANDIN G/H SYNTHASE 2)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	LEU A1812 ARG A1808 MET A1675	None	0.82A	4m11C-4yknA: undetectable	4m11C-4yknA: 17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MX0_A_BCZA513_1 (NEURAMINIDASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	3 / 3	ARG A1088 ASP A1746 ARG A1038	None	1.01A	4mx0A-4yknA: undetectable	4mx0A-4yknA: 13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_A_ADNA401_1 (ADENOSINE KINASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 12	LEU A1396 ASN A1370 ALA A1400 ASN A 377 GLY A 376	None	1.21A	4n09A-4yknA: undetectable	4n09A-4yknA: 12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_C_ADNC401_1 (ADENOSINE KINASE)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 12	GLY A1359 ASN A1370 ALA A1400 LEU A1429 GLY A 376	None	0.83A	4n09C-4yknA: undetectable	4n09C-4yknA: 12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R29_C_SAMC301_0 (UNCHARACTERIZED PROTEIN)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 12	ALA A1747 ARG A1704 GLY A1750 PHE A1751 GLU A1710	None	1.27A	4r29C-4yknA: undetectable	4r29C-4yknA: 9.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 12	ILE A1848 VAL A1851 THR A1856 MET A1922 ILE A1932	4EL A2101 (-3.9A) 4EL A2101 (-4.0A) 4EL A2101 ( 4.3A) 4EL A2101 (-3.7A) 4EL A2101 (-3.8A)	1.19A	4xe0A-4yknA: 31.3	4xe0A-4yknA: 32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	7 / 12	MET A1772 PRO A1778 TYR A1836 VAL A1851 THR A1856 MET A1922 ILE A1932	4EL A2101 (-4.6A) 4EL A2101 (-4.2A) 4EL A2101 (-4.1A) 4EL A2101 (-4.0A) 4EL A2101 ( 4.3A) 4EL A2101 (-3.7A) 4EL A2101 (-3.8A)	1.06A	4xe0A-4yknA: 31.3	4xe0A-4yknA: 32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	8 / 12	PRO A1778 TRP A1780 ILE A1800 TYR A1836 VAL A1851 THR A1856 MET A1922 ILE A1932	4EL A2101 (-4.2A) None 4EL A2101 ( 4.4A) 4EL A2101 (-4.1A) 4EL A2101 (-4.0A) 4EL A2101 ( 4.3A) 4EL A2101 (-3.7A) 4EL A2101 (-3.8A)	0.44A	4xe0A-4yknA: 31.3	4xe0A-4yknA: 32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JH7_D_6K9D502_0 (TUBULIN BETA-2B CHAIN)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 11	GLN A1637 ASN A1677 THR A1679 PRO A1607 TYR A1641	None	1.45A	5jh7D-4yknA: undetectable	5jh7D-4yknA: 16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFP_A_8W5A804_2 (GLUCOCORTICOID RECEPTOR)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 4	LEU A2001 MET A1820 ILE A2019 LEU A1911	None	1.14A	5nfpA-4yknA: undetectable	5nfpA-4yknA: 11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y1Y_A_HNQA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 8	LEU A1092 LEU A1094 CYH A1036 ILE A1045	None	0.90A	5y1yA-4yknA: undetectable	5y1yA-4yknA: 6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Z_D_9CRD501_0 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 12	ILE A1427 ILE A1336 LEU A1443 ALA A1442 ILE A1360	None	1.04A	6a5zD-4yknA: undetectable	6a5zD-4yknA: 5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_B_TA1B501_2 (TUBULIN BETA CHAIN)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 5	LEU A1831 THR A1908 ARG A1818 PRO A1835	None	1.29A	6ew0B-4yknA: undetectable	6ew0B-4yknA: 4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_D_TA1D501_2 (TUBULIN BETA CHAIN)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 5	LEU A1831 THR A1908 ARG A1818 PRO A1835	None	1.29A	6ew0D-4yknA: undetectable	6ew0D-4yknA: 4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_H_TA1H501_2 (TUBULIN BETA CHAIN)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 5	LEU A1831 THR A1908 ARG A1818 PRO A1835	None	1.29A	6ew0H-4yknA: undetectable	6ew0H-4yknA: 4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_I_TA1I501_2 (TUBULIN BETA CHAIN)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 5	LEU A1831 THR A1908 ARG A1818 PRO A1835	None	1.29A	6ew0I-4yknA: undetectable	6ew0I-4yknA: 4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGC_A_D95A816_0 (GEPHYRIN)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	5 / 11	MET A2005 PHE A2002 ILE A2019 LEU A1938 ILE A1819	None	1.35A	6fgcA-4yknA: undetectable	6fgcA-4yknA: 4.73

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AFS_A_TESA325_1","3-ALPHA-HYDROXYSTEROID DEHYDROGENASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A1287;TYR A1250;THR A1229;TYR A1207","None","1.19A","1afsA-4yknA:undetectable","1afsA-4yknA:12.65"],["1AFS_B_TESB325_1","3-ALPHA-HYDROXYSTEROID DEHYDROGENASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A1287;TYR A1250;THR A1229;TYR A1207","None","1.18A","1afsB-4yknA:undetectable","1afsB-4yknA:12.65"],["1L7F_A_BCZA801_1","NEURAMINIDASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"ARG A1088;ARG A1704;ARG A1038","None","1.05A","1l7fA-4yknA:undetectable","1l7fA-4yknA:13.52"],["1L7H_A_BCZA801_1","NEURAMINIDASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"ARG A1088;ARG A1704;ARG A1038","None","1.05A","1l7hA-4yknA:undetectable","1l7hA-4yknA:13.52"],["1NW5_A_SAMA401_1","MODIFICATION METHYLASE RSRI","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"ASP A1915;HIS A1936;ASP A1933","None;None;4EL A2101 (-4.6A)","0.89A","1nw5A-4yknA:undetectable","1nw5A-4yknA:13.05"],["1XQL_A_4AXA605_1","ALANINE RACEMASE;ALANINE RACEMASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"TYR A 470;LYS A 567;TYR A 463;TYR A 467","None","1.49A","1xqlA-4yknA:undetectable;1xqlB-4yknA:undetectable","1xqlA-4yknA:13.93;1xqlB-4yknA:13.93"],["2CIZ_A_ACTA1321_0","CHLOROPEROXIDASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A1831;PHE A1980;VAL A1906;ALA A1987","None","1.16A","2cizA-4yknA:undetectable","2cizA-4yknA:12.11"],["2F8L_A_SAMA400_1","HYPOTHETICAL PROTEIN LMO1582","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"THR A 371;THR A 354;ASP A 352;ASP A1390","None","1.43A","2f8lA-4yknA:undetectable","2f8lA-4yknA:14.43"],["2OAX_D_SNLD4001_2","MINERALOCORTICOID RECEPTOR","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A1956;LEU A1877;CYH A1971;THR A1972","None","1.40A","2oaxD-4yknA:undetectable","2oaxD-4yknA:11.68"],["2OPX_A_DXCA1003_0","ALDEHYDE DEHYDROGENASE A","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"ILE A1393;LEU A1396;ASP A1390;ALA A1333","None","0.94A","2opxA-4yknA:undetectable","2opxA-4yknA:16.24"],["2P2F_A_ACTA653_0","ACETYL-COENZYME A SYNTHETASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"THR A1679;VAL A1461;GLY A1460;TRP A1446","None","1.08A","2p2fA-4yknA:undetectable","2p2fA-4yknA:17.75"],["2QE6_A_SAMA400_1","UNCHARACTERIZED PROTEIN TFU_2867","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"ASN A 377;ARG A 373;ASP A1454","None","1.00A","2qe6A-4yknA:undetectable","2qe6A-4yknA:11.12"],["2QE6_B_SAMB400_1","UNCHARACTERIZED PROTEIN TFU_2867","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"ASN A 377;ARG A 373;ASP A1454","None","0.94A","2qe6B-4yknA:undetectable","2qe6B-4yknA:11.12"],["2W3A_B_TOPB1189_1","DIHYDROFOLATE REDUCTASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"ILE A1964;ALA A1902;PHE A1897;ILE A1857;LEU A1877","None","1.12A","2w3aB-4yknA:undetectable","2w3aB-4yknA:9.04"],["2YGP_A_PCFA1213_0","WNT INHIBITORY FACTOR 1","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"ILE A1391;LEU A1367;ILE A1393;VAL A1437;PHE A1430","None","1.10A","2ygpA-4yknA:undetectable","2ygpA-4yknA:9.32"],["3ADX_A_IMNA2_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"ILE A1921;LEU A1929;PHE A1930;LEU A1814","None","0.91A","3adxA-4yknA:undetectable","3adxA-4yknA:12.33"],["3APW_A_DP0A190_2","ALPHA-1-ACID GLYCOPROTEIN 2","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"VAL A1706;ARG A1704;HIS A1701;PHE A1119","None","1.42A","3apwA-4yknA:0.0","3apwA-4yknA:8.46"],["3EEY_D_SAMD300_1","PUTATIVE RRNA METHYLASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"ASN A1920;ASP A1810;GLN A1809","None","0.77A","3eeyD-4yknA:undetectable","3eeyD-4yknA:9.10"],["3JQ7_B_DX2B271_1","PTERIDINE REDUCTASE 1","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"SER A 474;TYR A 470;LEU A1445;PRO A1471","None","1.21A","3jq7B-4yknA:undetectable","3jq7B-4yknA:11.81"],["3L35_H_DHIH3_0","GP41 N-PEPTIDE;HIV ENTRY INHIBITOR PIE12","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"LEU A1452;TRP A1424;GLY A1425","None","0.65A","3l35A-4yknA:undetectable;3l35H-4yknA:undetectable","3l35A-4yknA:3.04;3l35H-4yknA:1.16"],["3L35_K_DHIK3_0","GP41 N-PEPTIDE;HIV ENTRY INHIBITOR PIE12","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"LEU A1452;TRP A1424;GLY A1425","None","0.69A","3l35B-4yknA:undetectable;3l35K-4yknA:undetectable","3l35B-4yknA:3.04;3l35K-4yknA:1.16"],["4A6D_A_SAMA1350_0","HYDROXYINDOLE O-METHYLTRANSFERASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"PHE A2016;LEU A1570;TRP A1574;GLY A1364;ASP A1603","None","0.99A","4a6dA-4yknA:undetectable","4a6dA-4yknA:13.59"],["4A6E_A_SAMA1349_0","HYDROXYINDOLE O-METHYLTRANSFERASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"PHE A2016;LEU A1570;TRP A1574;GLY A1364;ASP A1603","None","1.01A","4a6eA-4yknA:undetectable","4a6eA-4yknA:13.59"],["4BBO_D_ACTD1113_0","BLR5658 PROTEIN","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"TRP A1383;LEU A1473;LEU A1404;THR A1358","None","1.25A","4bboD-4yknA:undetectable","4bboD-4yknA:6.75"],["4BQT_C_C5EC301_0","SOLUBLE ACETYLCHOLINE RECEPTOR","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"VAL A1923;TYR A1904;CYH A1901;ILE A1921","None","1.22A","4bqtC-4yknA:undetectable;4bqtD-4yknA:undetectable","4bqtC-4yknA:10.51;4bqtD-4yknA:10.51"],["4DTA_A_ADNA401_1","APH(2'')-ID","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"ILE A1816;ILE A1910;HIS A1994;LEU A2026;ILE A1991","None","1.24A","4dtaA-4yknA:2.8","4dtaA-4yknA:11.90"],["4F4D_A_CHDA506_0","FERROCHELATASE, MITOCHONDRIAL","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"PRO A1566;LEU A1570;ILE A1543;ARG A 340","None","1.39A","4f4dA-4yknA:undetectable","4f4dA-4yknA:13.77"],["4K50_E_ACTE502_0","RNA POLYMERASE 3D-POL","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"ARG A1230;LYS A1228;LYS A1227","None","1.22A","4k50E-4yknA:undetectable","4k50E-4yknA:15.82"],["4KM0_B_CP6B201_1","DIHYDROFOLATE REDUCTASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"ILE A1991;ALA A1907;ILE A1817;PHE A1998;ILE A1823","None","1.13A","4km0B-4yknA:undetectable","4km0B-4yknA:8.95"],["4L4C_B_CAMB502_0","CAMPHOR 5-MONOOXYGENASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"PHE A1139;LEU A1639;VAL A1146;ILE A1143","None","0.93A","4l4cB-4yknA:undetectable","4l4cB-4yknA:15.44"],["4M11_C_MXMC606_2","PROSTAGLANDIN G\/H SYNTHASE 2","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"LEU A1812;ARG A1808;MET A1675","None","0.82A","4m11C-4yknA:undetectable","4m11C-4yknA:17.24"],["4MX0_A_BCZA513_1","NEURAMINIDASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",3,"ARG A1088;ASP A1746;ARG A1038","None","1.01A","4mx0A-4yknA:undetectable","4mx0A-4yknA:13.64"],["4N09_A_ADNA401_1","ADENOSINE KINASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"LEU A1396;ASN A1370;ALA A1400;ASN A 377;GLY A 376","None","1.21A","4n09A-4yknA:undetectable","4n09A-4yknA:12.42"],["4N09_C_ADNC401_1","ADENOSINE KINASE","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"GLY A1359;ASN A1370;ALA A1400;LEU A1429;GLY A 376","None","0.83A","4n09C-4yknA:undetectable","4n09C-4yknA:12.42"],["4R29_C_SAMC301_0","UNCHARACTERIZED PROTEIN","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"ALA A1747;ARG A1704;GLY A1750;PHE A1751;GLU A1710","None","1.27A","4r29C-4yknA:undetectable","4r29C-4yknA:9.97"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"ILE A1848;VAL A1851;THR A1856;MET A1922;ILE A1932","4EL A2101 (-3.9A);4EL A2101 (-4.0A);4EL A2101 ( 4.3A);4EL A2101 (-3.7A);4EL A2101 (-3.8A)","1.19A","4xe0A-4yknA:31.3","4xe0A-4yknA:32.46"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",7,"MET A1772;PRO A1778;TYR A1836;VAL A1851;THR A1856;MET A1922;ILE A1932","4EL A2101 (-4.6A);4EL A2101 (-4.2A);4EL A2101 (-4.1A);4EL A2101 (-4.0A);4EL A2101 ( 4.3A);4EL A2101 (-3.7A);4EL A2101 (-3.8A)","1.06A","4xe0A-4yknA:31.3","4xe0A-4yknA:32.46"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",8,"PRO A1778;TRP A1780;ILE A1800;TYR A1836;VAL A1851;THR A1856;MET A1922;ILE A1932","4EL A2101 (-4.2A);None;4EL A2101 ( 4.4A);4EL A2101 (-4.1A);4EL A2101 (-4.0A);4EL A2101 ( 4.3A);4EL A2101 (-3.7A);4EL A2101 (-3.8A)","0.44A","4xe0A-4yknA:31.3","4xe0A-4yknA:32.46"],["5JH7_D_6K9D502_0","TUBULIN BETA-2B CHAIN","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"GLN A1637;ASN A1677;THR A1679;PRO A1607;TYR A1641","None","1.45A","5jh7D-4yknA:undetectable","5jh7D-4yknA:16.01"],["5NFP_A_8W5A804_2","GLUCOCORTICOID RECEPTOR","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A2001;MET A1820;ILE A2019;LEU A1911","None","1.14A","5nfpA-4yknA:undetectable","5nfpA-4yknA:11.69"],["5Y1Y_A_HNQA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A1092;LEU A1094;CYH A1036;ILE A1045","None","0.90A","5y1yA-4yknA:undetectable","5y1yA-4yknA:6.68"],["6A5Z_D_9CRD501_0","RETINOIC ACID RECEPTOR RXR-ALPHA","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"ILE A1427;ILE A1336;LEU A1443;ALA A1442;ILE A1360","None","1.04A","6a5zD-4yknA:undetectable","6a5zD-4yknA:5.50"],["6EW0_B_TA1B501_2","TUBULIN BETA CHAIN","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A1831;THR A1908;ARG A1818;PRO A1835","None","1.29A","6ew0B-4yknA:undetectable","6ew0B-4yknA:4.52"],["6EW0_D_TA1D501_2","TUBULIN BETA CHAIN","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A1831;THR A1908;ARG A1818;PRO A1835","None","1.29A","6ew0D-4yknA:undetectable","6ew0D-4yknA:4.52"],["6EW0_H_TA1H501_2","TUBULIN BETA CHAIN","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A1831;THR A1908;ARG A1818;PRO A1835","None","1.29A","6ew0H-4yknA:undetectable","6ew0H-4yknA:4.52"],["6EW0_I_TA1I501_2","TUBULIN BETA CHAIN","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",4,"LEU A1831;THR A1908;ARG A1818;PRO A1835","None","1.29A","6ew0I-4yknA:undetectable","6ew0I-4yknA:4.52"],["6FGC_A_D95A816_0","GEPHYRIN","4ykn","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN","Homo sapiens",5,"MET A2005;PHE A2002;ILE A2019;LEU A1938;ILE A1819","None","1.35A","6fgcA-4yknA:undetectable","6fgcA-4yknA:4.73"]]