SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4yl0 PROSTAGLANDIN E
SYNTHASE
(Homo
sapiens) 		4 / 7 PHE A  16
SER A  10
PHE A  82
ALA A  99
 None
 1.18A 1fxvA-4yl0A:
undetectable
1fxvB-4yl0A:
undetectable		 1fxvA-4yl0A:
22.39
1fxvB-4yl0A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4yl0 PROSTAGLANDIN E
SYNTHASE
(Homo
sapiens) 		3 / 3 LYS A  26
VAL A  30
HIS A  72
 None
 1.20A 3tj7A-4yl0A:
undetectable		 3tj7A-4yl0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4yl0 PROSTAGLANDIN E
SYNTHASE
(Homo
sapiens) 		4 / 6 ARG A  70
ALA A  71
LEU A 118
LYS A 120
 None
None
PEG  A 206 ( 4.0A)
BOG  A 204 (-4.0A)
 0.99A 4ot2A-4yl0A:
3.0		 4ot2A-4yl0A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4yl0 PROSTAGLANDIN E
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  65
THR A  34
ARG A  38
 None
 0.72A 5b2sB-4yl0A:
undetectable		 5b2sB-4yl0A:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4yl0 PROSTAGLANDIN E
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  65
THR A  34
ARG A  38
 None
 0.71A 5b2tB-4yl0A:
2.1		 5b2tB-4yl0A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4yl0 PROSTAGLANDIN E
SYNTHASE
(Homo
sapiens) 		4 / 8 HIS A 113
ASN A  74
ARG A  70
ARG A  73
 GSH  A 202 (-4.0A)
GSH  A 202 (-3.6A)
None
GSH  A 202 (-3.3A)
 1.29A 5db5A-4yl0A:
undetectable
5db5B-4yl0A:
undetectable		 5db5A-4yl0A:
17.24
5db5B-4yl0A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4yl0 PROSTAGLANDIN E
SYNTHASE
(Homo
sapiens) 		4 / 8 ILE A 144
PHE A  87
LEU A  13
ALA A  12
 None
 0.88A 5y7pC-4yl0A:
undetectable		 5y7pC-4yl0A:
18.21