SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yl6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4yl6 MALCAVERNIN
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
(Homo
sapiens) 		5 / 12 LEU A 338
LEU A 310
LEU A 299
LEU B  14
TYR A 302
 None
 1.12A 3vw7A-4yl6A:
undetectable		 3vw7A-4yl6A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4yl6 MALCAVERNIN
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
(Homo
sapiens;
Homo
sapiens) 		5 / 11 ILE B  10
ALA A 320
LEU A 341
PHE A 318
LEU A 353
 None
 1.34A 4i1nA-4yl6B:
undetectable		 4i1nA-4yl6B:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4yl6 MALCAVERNIN
(Homo
sapiens) 		5 / 12 LEU A 369
PHE A 368
LEU A 321
LEU A 341
LEU A 306
 None
 1.13A 5iepA-4yl6A:
undetectable		 5iepA-4yl6A:
26.39