SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AL4_A_DVAA6_0
(GRAMICIDIN D)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		4 / 5 ALA A 108
TRP A 123
TRP A  77
TRP A  67
 None
 1.47A 1al4A-4ylaA:
undetectable
1al4B-4ylaA:
undetectable		 1al4A-4ylaA:
18.64
1al4B-4ylaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		4 / 7 HIS A 258
LEU A 299
ASP A 249
PHE A 285
 None
 1.13A 1ismB-4ylaA:
undetectable		 1ismB-4ylaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		4 / 6 LEU A 141
TRP A  67
MET A 162
LEU A  63
 None
 1.41A 2oz7A-4ylaA:
undetectable		 2oz7A-4ylaA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 12 GLY A 182
LEU A 190
VAL A 236
ALA A 184
GLY A 217
 SO4  A 402 (-3.2A)
None
None
None
None
 1.38A 2vmyB-4ylaA:
undetectable		 2vmyB-4ylaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		4 / 6 ARG A  24
GLY A 339
ALA A 335
LEU A 347
 None
 0.99A 3bgdA-4ylaA:
undetectable		 3bgdA-4ylaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 12 LEU A 197
LEU A 224
LEU A 176
ALA A 193
LEU A 190
 None
 0.98A 3r9cA-4ylaA:
undetectable		 3r9cA-4ylaA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		4 / 6 GLY A 220
ASP A   4
ASN A 349
GLU A  89
 ILV  A 401 (-3.8A)
ILV  A 401 (-4.5A)
ILV  A 401 (-3.6A)
ILV  A 401 (-3.3A)
 0.83A 3vywC-4ylaA:
undetectable		 3vywC-4ylaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		3 / 3 ARG A 207
ARG A 200
TRP A 203
 None
 1.47A 4cpzE-4ylaA:
undetectable		 4cpzE-4ylaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		4 / 6 GLY A  68
GLY A 122
GLU A 124
TYR A 125
 None
 0.87A 4dxuA-4ylaA:
undetectable		 4dxuA-4ylaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLW_A_TESA1001_1
(ANDROGEN RECEPTOR)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 12 LEU A 206
GLY A 205
GLN A 204
VAL A 199
MET A 194
 None
 1.29A 4hlwA-4ylaA:
undetectable		 4hlwA-4ylaA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 11 CYH A 366
ALA A 369
ALA A 337
THR A 338
CYH A  42
 None
 1.48A 4qw3V-4ylaA:
undetectable
4qw3W-4ylaA:
0.2		 4qw3V-4ylaA:
18.93
4qw3W-4ylaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 12 CYH A 366
ALA A 369
ALA A 337
THR A 338
CYH A  42
 None
 1.47A 5d0xH-4ylaA:
undetectable
5d0xI-4ylaA:
undetectable		 5d0xH-4ylaA:
18.93
5d0xI-4ylaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 12 ALA A 241
PRO A   5
PHE A   6
GLY A 220
SER A 221
 None
None
None
ILV  A 401 (-3.8A)
ILV  A 401 (-4.7A)
 1.19A 5hfjB-4ylaA:
undetectable		 5hfjB-4ylaA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 12 ALA A 241
PRO A   5
PHE A   6
GLY A 220
SER A 221
 None
None
None
ILV  A 401 (-3.8A)
ILV  A 401 (-4.7A)
 1.11A 5hfjD-4ylaA:
undetectable		 5hfjD-4ylaA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 12 ALA A 241
PRO A   5
PHE A   6
GLY A 220
SER A 221
 None
None
None
ILV  A 401 (-3.8A)
ILV  A 401 (-4.7A)
 1.18A 5hfjF-4ylaA:
undetectable		 5hfjF-4ylaA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 12 LEU A  90
HIS A  43
ALA A  56
THR A 105
PRO A 170
 None
None
None
DST  A 405 ( 3.8A)
None
 1.25A 5hnzB-4ylaA:
undetectable		 5hnzB-4ylaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		4 / 5 ARG A 155
GLY A  10
ASN A   9
ASP A   8
 None
 0.89A 6dwjB-4ylaA:
undetectable
6dwjD-4ylaA:
undetectable		 6dwjB-4ylaA:
22.00
6dwjD-4ylaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		3 / 3 LEU A 143
LEU A 224
ARG A 139
 None
 0.56A 6fgcA-4ylaA:
undetectable		 6fgcA-4ylaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		3 / 3 LEU A 143
LEU A 224
ARG A 139
 None
 0.59A 6fgdA-4ylaA:
undetectable		 6fgdA-4ylaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		4 / 7 TYR A 125
HIS A 160
LEU A 141
VAL A 140
 None
 1.08A 6g2pA-4ylaA:
undetectable		 6g2pA-4ylaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		4 / 8 ALA A 329
GLY A  47
LEU A  46
ALA A 100
 None
 0.73A 6mdqA-4ylaA:
undetectable		 6mdqA-4ylaA:
11.65