SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 10 ALA A 275
THR A 274
ALA A 273
GLY A 230
ALA A 150
 None
 1.00A 2f16K-4yleA:
undetectable
2f16L-4yleA:
undetectable		 2f16K-4yleA:
22.29
2f16L-4yleA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 10 ALA A 275
THR A 274
ALA A 273
VAL A 311
ALA A 150
 None
 0.95A 2f16K-4yleA:
undetectable
2f16L-4yleA:
undetectable		 2f16K-4yleA:
22.29
2f16L-4yleA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 10 ALA A 275
THR A 274
ALA A 273
GLY A 230
ALA A 150
 None
 1.00A 2f16Y-4yleA:
undetectable
2f16Z-4yleA:
undetectable		 2f16Y-4yleA:
22.29
2f16Z-4yleA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 10 ALA A 275
THR A 274
ALA A 273
VAL A 311
ALA A 150
 None
 0.95A 2f16Y-4yleA:
undetectable
2f16Z-4yleA:
undetectable		 2f16Y-4yleA:
22.29
2f16Z-4yleA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 10 ILE A 119
ILE A 118
ASN A 122
VAL A  85
ILE A 123
 None
 1.25A 2nnhB-4yleA:
undetectable		 2nnhB-4yleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		4 / 7 GLY A 143
GLN A 277
PHE A  46
PHE A  47
 None
UNL  A 401 ( 3.2A)
UNL  A 401 ( 3.7A)
None
 0.91A 2qmzA-4yleA:
4.2
2qmzB-4yleA:
4.0		 2qmzA-4yleA:
22.52
2qmzB-4yleA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 7 GLY A 143
THR A 309
GLN A 277
PHE A  46
PHE A  47
 None
None
UNL  A 401 ( 3.2A)
UNL  A 401 ( 3.7A)
None
 1.07A 2qx4A-4yleA:
2.1
2qx4B-4yleA:
4.3		 2qx4A-4yleA:
22.52
2qx4B-4yleA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		4 / 6 GLY A 143
GLN A 277
PHE A  46
PHE A  47
 None
UNL  A 401 ( 3.2A)
UNL  A 401 ( 3.7A)
None
 0.99A 2qx6A-4yleA:
4.5
2qx6B-4yleA:
4.0		 2qx6A-4yleA:
22.52
2qx6B-4yleA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		4 / 7 ILE A 169
VAL A 254
GLY A 255
THR A 183
 None
 0.74A 2wd9A-4yleA:
6.7		 2wd9A-4yleA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		4 / 8 ILE A 169
VAL A 254
GLY A 255
THR A 183
 None
 0.78A 2wd9B-4yleA:
6.3		 2wd9B-4yleA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		4 / 8 GLY A 154
ILE A 169
MET A 195
ALA A 273
 None
 0.88A 2x0pA-4yleA:
undetectable		 2x0pA-4yleA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 12 ASN A 231
GLY A 255
VAL A 253
MET A 265
ILE A 236
 UNL  A 401 ( 3.9A)
None
None
None
None
 1.41A 3h52A-4yleA:
undetectable		 3h52A-4yleA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 9 LEU A 157
GLY A 154
MET A 217
LEU A 227
VAL A 254
 None
 1.09A 4x3mB-4yleA:
4.4		 4x3mB-4yleA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 9 ALA A 275
THR A 274
ALA A 273
GLY A 230
ALA A 150
 None
 1.13A 5l5zK-4yleA:
undetectable
5l5zL-4yleA:
undetectable		 5l5zK-4yleA:
23.29
5l5zL-4yleA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 11 ALA A 275
THR A 274
ALA A 273
GLY A 230
ALA A 150
 None
 1.02A 5lf3K-4yleA:
undetectable
5lf3L-4yleA:
undetectable		 5lf3K-4yleA:
22.76
5lf3L-4yleA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 11 ALA A 275
THR A 274
ALA A 273
GLY A 230
ALA A 150
 None
 1.02A 5lf3Y-4yleA:
undetectable
5lf3Z-4yleA:
undetectable		 5lf3Y-4yleA:
22.76
5lf3Z-4yleA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		6 / 11 ALA A 275
THR A 274
ALA A 273
VAL A 311
GLY A 230
ALA A 150
 None
 1.11A 5lf7K-4yleA:
undetectable
5lf7L-4yleA:
undetectable		 5lf7K-4yleA:
22.76
5lf7L-4yleA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		6 / 11 ALA A 275
THR A 274
ALA A 273
VAL A 311
GLY A 230
ALA A 150
 None
 1.11A 5lf7Y-4yleA:
undetectable
5lf7Z-4yleA:
undetectable		 5lf7Y-4yleA:
22.76
5lf7Z-4yleA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 12 VAL A  97
LEU A  67
LEU A 291
ILE A 294
ALA A 290
 None
 1.30A 5xprA-4yleA:
undetectable		 5xprA-4yleA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4yle PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Burkholderia
multivorans) 		5 / 12 ALA A 235
GLY A 237
GLY A 210
LEU A 266
ASN A 233
 None
 1.07A 5ybbA-4yleA:
undetectable		 5ybbA-4yleA:
20.99