SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ylg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 LEU A 141
LEU A 103
ILE A 132
LEU A  21
VAL A  64
 None
 1.19A 1hrkA-4ylgA:
3.9		 1hrkA-4ylgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 LEU A 141
LEU A 103
ILE A 132
LEU A  21
VAL A  64
 None
 1.21A 2po7A-4ylgA:
3.9		 2po7A-4ylgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 LEU A 141
LEU A 103
ILE A 132
LEU A  21
VAL A  64
 None
 1.21A 2po7B-4ylgA:
4.0		 2po7B-4ylgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 9 ALA A  83
LEU A 118
ILE A  29
LEU A  33
PHE A  59
 None
 1.37A 3fl9D-4ylgA:
undetectable		 3fl9D-4ylgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.86A 4ax8A-4ylgA:
undetectable		 4ax8A-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.88A 4aztA-4ylgA:
undetectable		 4aztA-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.85A 4azvA-4ylgA:
undetectable		 4azvA-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 10 LEU A 162
LEU A 166
LEU A   8
ILE A  29
VAL A  52
 None
 1.09A 4mk4A-4ylgA:
2.6		 4mk4A-4ylgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4ylg ADP-RIBOSYLATION
FACTOR
(Entamoeba
histolytica) 		5 / 12 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.95A 4uw0A-4ylgA:
undetectable		 4uw0A-4ylgA:
15.88