SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 LEU A  89
VAL A  25
ILE A 169
GLU A 184
VAL A 100
 None
 1.03A 1cqpA-4ylyA:
2.6
1cqpB-4ylyA:
2.4		 1cqpA-4ylyA:
18.66
1cqpB-4ylyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 LEU A  89
VAL A  25
ILE A 169
LEU A 102
VAL A 100
 None
 1.15A 1cqpA-4ylyA:
2.6
1cqpB-4ylyA:
2.4		 1cqpA-4ylyA:
18.66
1cqpB-4ylyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 9 GLY A  22
GLU A  60
ILE A 162
ALA A 165
VAL A 161
 None
 1.40A 2drdA-4ylyA:
undetectable		 2drdA-4ylyA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 LEU A  37
ILE A  75
VAL A  72
CYH A   3
VAL A   5
 None
 1.23A 2g72B-4ylyA:
undetectable		 2g72B-4ylyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 PHE A  42
LYS A  41
ASP A  77
TYR A  79
 None
 1.27A 3aruA-4ylyA:
undetectable		 3aruA-4ylyA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 132
GLY A 134
VAL A 161
ASP A  92
ILE A 131
 None
 1.00A 3embA-4ylyA:
undetectable		 3embA-4ylyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 SER A 116
GLY A 113
PRO A  61
ASN A   9
 None
 0.91A 3lslA-4ylyA:
undetectable
3lslD-4ylyA:
undetectable		 3lslA-4ylyA:
22.48
3lslD-4ylyA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 PRO A  61
ASN A   9
SER A 116
GLY A 113
 None
 0.81A 3lslA-4ylyA:
undetectable
3lslD-4ylyA:
undetectable		 3lslA-4ylyA:
22.48
3lslD-4ylyA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 VAL A  72
ILE A  75
LEU A  30
LEU A  37
 None
 0.87A 4l1wA-4ylyA:
undetectable		 4l1wA-4ylyA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 VAL A 189
ILE A 162
VAL A  25
LEU A  89
ALA A 168
 None
 1.32A 4m11C-4ylyA:
undetectable		 4m11C-4ylyA:
15.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		8 / 9 HIS A  19
LEU A  93
GLY A 110
HIS A 111
ASN A 112
VAL A 142
VAL A 146
LEU A 147
 None
 0.71A 4qd3A-4ylyA:
28.3		 4qd3A-4ylyA:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		4 / 5 GLY A 134
ARG A  18
GLU A 154
PHE A 150
 None
 0.87A 4r82A-4ylyA:
undetectable
4r82B-4ylyA:
undetectable		 4r82A-4ylyA:
22.61
4r82B-4ylyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 132
GLY A 134
VAL A 161
ASP A  92
ILE A 131
 None
 0.99A 5ehiA-4ylyA:
undetectable		 5ehiA-4ylyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 132
GLY A 134
VAL A 161
ASP A  92
ILE A 131
 None
 1.04A 5ehiC-4ylyA:
undetectable		 5ehiC-4ylyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 132
GLY A 134
VAL A 161
ASP A  92
ILE A 131
 None
 1.00A 5eiwA-4ylyA:
undetectable		 5eiwA-4ylyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 132
GLY A 134
VAL A 161
ASP A  92
ILE A 131
 None
 0.98A 5ekxA-4ylyA:
undetectable		 5ekxA-4ylyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 HIS A  19
ASP A  91
HIS A 111
MET A  65
 None
 1.44A 5m45A-4ylyA:
undetectable		 5m45A-4ylyA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 HIS A  19
ASP A  91
HIS A 111
MET A  65
 None
 1.43A 5m45D-4ylyA:
undetectable		 5m45D-4ylyA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 HIS A  19
ASP A  91
HIS A 111
MET A  65
 None
 1.43A 5m45G-4ylyA:
0.0		 5m45G-4ylyA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 HIS A  19
ASP A  91
HIS A 111
MET A  65
 None
 1.43A 5m45J-4ylyA:
undetectable		 5m45J-4ylyA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4yly PEPTIDYL-TRNA
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 GLY A   6
VAL A  88
PHE A 126
GLY A 110
GLY A 109
 None
 1.14A 6brdB-4ylyA:
2.8		 6brdB-4ylyA:
16.41