SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ym3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ym3 GALECTIN-4
(Homo
sapiens) 		4 / 8 SER A 220
ASN A 238
GLN A 313
PHE A 221
 None
LAT  A 401 (-4.0A)
None
None
 1.35A 1rs6A-4ym3A:
undetectable		 1rs6A-4ym3A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ym3 GALECTIN-4
(Homo
sapiens) 		4 / 8 SER A 220
ASN A 238
GLN A 313
PHE A 221
 None
LAT  A 401 (-4.0A)
None
None
 1.34A 1rs7B-4ym3A:
undetectable		 1rs7B-4ym3A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4ym3 GALECTIN-4
(Homo
sapiens) 		5 / 10 ARG A 306
GLY A 281
ASP A 296
ILE A 208
ALA A 234
 None
 0.82A 1sh9B-4ym3A:
undetectable		 1sh9B-4ym3A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4ym3 GALECTIN-4
(Homo
sapiens) 		5 / 10 ILE A 233
ALA A 234
ILE A 278
GLU A 311
ILE A 223
 None
 1.40A 2dm6A-4ym3A:
undetectable
2dm6B-4ym3A:
undetectable		 2dm6A-4ym3A:
18.64
2dm6B-4ym3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4ym3 GALECTIN-4
(Homo
sapiens) 		5 / 12 LEU A 202
ALA A 234
ASP A 232
ILE A 223
LEU A 198
 None
 0.87A 2o4nA-4ym3A:
undetectable		 2o4nA-4ym3A:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 6 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.27A 3galA-4ym3A:
22.8		 3galA-4ym3A:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 6 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.30A 3galB-4ym3A:
22.6		 3galB-4ym3A:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4ym3 GALECTIN-4
(Homo
sapiens) 		5 / 10 VAL A 287
PHE A 295
PHE A 221
ILE A 223
PHE A 268
 None
 1.31A 3t3rD-4ym3A:
undetectable		 3t3rD-4ym3A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ym3 GALECTIN-4
(Homo
sapiens) 		4 / 7 SER A 220
ASN A 238
GLN A 313
PHE A 221
 None
LAT  A 401 (-4.0A)
None
None
 1.44A 4kcnB-4ym3A:
undetectable		 4kcnB-4ym3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4ym3 GALECTIN-4
(Homo
sapiens) 		5 / 10 MET A 241
VAL A 192
ILE A 210
LEU A 318
LEU A 235
 None
 1.04A 5ienB-4ym3A:
1.6		 5ienB-4ym3A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 7 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.19A 6b8kA-4ym3A:
22.4		 6b8kA-4ym3A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 8 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.33A 6b94A-4ym3A:
18.7		 6b94A-4ym3A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 4ym3 GALECTIN-4
(Homo
sapiens) 		6 / 10 HIS A 236
ASN A 238
ARG A 240
ASN A 249
TRP A 256
GLU A 259
 LAT  A 401 (-3.9A)
LAT  A 401 (-4.0A)
LAT  A 401 (-2.6A)
LAT  A 401 (-3.7A)
LAT  A 401 ( 3.8A)
LAT  A 401 (-3.1A)
 0.35A 6b94A-4ym3A:
18.7
6b94B-4ym3A:
18.2		 6b94A-4ym3A:
24.46
6b94B-4ym3A:
24.46