SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ymd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4ymd COLLECTIN-11
(Homo
sapiens) 		4 / 7 PHE A 225
GLU A 183
TRP A 251
ASN A 186
 None
 1.03A 1jqdA-4ymdA:
undetectable		 1jqdA-4ymdA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4ymd COLLECTIN-11
(Homo
sapiens) 		3 / 3 ASN A 252
PHE A 202
VAL A 254
 MAN  A 302 ( 2.6A)
None
MAN  A 302 ( 4.7A)
 0.74A 1kijA-4ymdA:
undetectable		 1kijA-4ymdA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ymd COLLECTIN-11
(Homo
sapiens) 		5 / 11 ARG A 200
GLY A 250
GLU A 232
GLU A 244
SER A 248
 MAN  A 301 (-3.4A)
None
MAN  A 302 ( 2.4A)
MAN  A 301 (-3.2A)
None
 1.25A 1odiA-4ymdA:
undetectable		 1odiA-4ymdA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ymd COLLECTIN-11
(Homo
sapiens) 		5 / 11 ARG A 200
GLY A 250
GLU A 232
GLU A 244
SER A 248
 MAN  A 301 (-3.4A)
None
MAN  A 302 ( 2.4A)
MAN  A 301 (-3.2A)
None
 1.23A 1odiC-4ymdA:
undetectable		 1odiC-4ymdA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ymd COLLECTIN-11
(Homo
sapiens) 		5 / 11 ARG A 200
GLY A 250
GLU A 232
GLU A 244
SER A 248
 MAN  A 301 (-3.4A)
None
MAN  A 302 ( 2.4A)
MAN  A 301 (-3.2A)
None
 1.24A 1odiD-4ymdA:
undetectable		 1odiD-4ymdA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ymd COLLECTIN-11
(Homo
sapiens) 		5 / 12 GLU A 211
GLY A 212
ASN A 234
ASP A 207
ALA A 213
 CA  A 303 (-2.2A)
None
MAN  A 302 ( 2.5A)
CA  A 303 ( 2.5A)
None
 1.28A 2br4B-4ymdA:
undetectable		 2br4B-4ymdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4ymd COLLECTIN-11
(Homo
sapiens) 		3 / 3 ASP A 218
ARG A 223
PRO A 221
 None
 1.08A 4wanC-4ymdA:
undetectable		 4wanC-4ymdA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4ymd COLLECTIN-11
(Homo
sapiens) 		3 / 5 GLY A 249
GLY A 187
GLU A 183
 None
 0.47A 4z2eA-4ymdA:
undetectable
4z2eD-4ymdA:
undetectable		 4z2eA-4ymdA:
15.45
4z2eD-4ymdA:
21.03