SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4yme SENSORY BOX/GGDEF
FAMILY PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ASP A 375
LEU A 377
GLY A 376
VAL A 431
ALA A 434
 None
 1.09A 1axwA-4ymeA:
undetectable		 1axwA-4ymeA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4yme SENSORY BOX/GGDEF
FAMILY PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ASP A 375
LEU A 377
GLY A 376
VAL A 431
ALA A 434
 None
 1.08A 4foxD-4ymeA:
undetectable		 4foxD-4ymeA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4yme SENSORY BOX/GGDEF
FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ILE A 409
CYH A 408
LEU A 450
ALA A 448
 None
 1.00A 5hrqE-4ymeA:
undetectable
5hrqF-4ymeA:
undetectable
5hrqJ-4ymeA:
undetectable		 5hrqE-4ymeA:
8.50
5hrqF-4ymeA:
30.00
5hrqJ-4ymeA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4yme SENSORY BOX/GGDEF
FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 PRO A 503
TYR A 502
VAL A 397
GLY A 401
 None
 0.95A 5nzyA-4ymeA:
undetectable		 5nzyA-4ymeA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4yme SENSORY BOX/GGDEF
FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ALA A 405
ILE A 394
ALA A 393
LEU A 390
 None
 0.78A 5te8B-4ymeA:
undetectable		 5te8B-4ymeA:
14.23