SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ymw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 11 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.17A 1akdA-4ymwJ:
undetectable		 1akdA-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 9 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.17A 1iwjA-4ymwJ:
undetectable		 1iwjA-4ymwJ:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 10 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.16A 1o76A-4ymwJ:
undetectable		 1o76A-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 11 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.15A 1phgA-4ymwJ:
undetectable		 1phgA-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 12 LEU J 167
LEU J 176
ALA J 199
PHE J 224
VAL J 175
 None
 1.33A 1rbpA-4ymwJ:
undetectable		 1rbpA-4ymwJ:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 4 THR J 193
GLY J 203
ASP J 204
ALA J 183
 None
 1.14A 1sg9A-4ymwJ:
2.7		 1sg9A-4ymwJ:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 9 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.13A 1t86B-4ymwJ:
undetectable		 1t86B-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 11 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.10A 2a1nA-4ymwJ:
undetectable		 2a1nA-4ymwJ:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 10 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.20A 2cp4A-4ymwJ:
undetectable		 2cp4A-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 7 THR J 188
LEU J  22
VAL J  24
VAL J  79
 None
 0.89A 2cppA-4ymwJ:
undetectable		 2cppA-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 10 VAL D 103
ALA D 148
ILE D 138
PRO D 139
ILE D 107
 None
 1.22A 3clbD-4ymwD:
undetectable		 3clbD-4ymwD:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 9 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.14A 3cppA-4ymwJ:
undetectable		 3cppA-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 6 ILE D 195
THR D  26
PHE D 153
PHE D 203
 None
 1.15A 3elzB-4ymwD:
undetectable		 3elzB-4ymwD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 10 VAL D 103
ALA D 148
ILE D 138
PRO D 139
ILE D 107
 None
 1.21A 3hbbD-4ymwD:
undetectable		 3hbbD-4ymwD:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 12 ILE J  60
VAL J  24
ILE J  32
VAL J 190
VAL J 157
 None
 1.04A 3iw1A-4ymwJ:
undetectable		 3iw1A-4ymwJ:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 12 VAL J   4
VAL J  24
ILE J  32
VAL J 190
VAL J 157
 None
 0.89A 3iw1A-4ymwJ:
undetectable		 3iw1A-4ymwJ:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 8 GLY D  37
SER D 100
ILE D  62
TYR D  58
 None
 0.68A 3pwwA-4ymwD:
undetectable		 3pwwA-4ymwD:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		3 / 3 LYS J 129
SER J 138
GLN J 141
 None
 1.10A 3si7A-4ymwJ:
19.6		 3si7A-4ymwJ:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 9 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.19A 4ek1B-4ymwJ:
undetectable		 4ek1B-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 8 THR J 188
LEU J  22
VAL J  24
VAL J  79
 None
 0.89A 4l4aA-4ymwJ:
undetectable		 4l4aA-4ymwJ:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 8 THR J 188
LEU J  22
VAL J  24
VAL J  79
 None
 0.85A 4l4eA-4ymwJ:
undetectable		 4l4eA-4ymwJ:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 8 THR J 188
LEU J  22
VAL J  24
VAL J  79
 None
 0.86A 4l4fA-4ymwJ:
undetectable		 4l4fA-4ymwJ:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 9 ALA J 117
GLN J 141
LEU J 137
LEU J 121
LEU J 145
 None
 1.49A 4x30A-4ymwJ:
undetectable		 4x30A-4ymwJ:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		3 / 3 SER J  38
GLU J 217
GLU J  28
 None
 0.68A 4ymgB-4ymwJ:
undetectable		 4ymgB-4ymwJ:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 9 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.15A 5cp4A-4ymwJ:
undetectable		 5cp4A-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 8 LEU D  25
GLY D  91
ALA D  90
SER D  93
 None
 0.76A 5f1aA-4ymwD:
undetectable		 5f1aA-4ymwD:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 7 LEU D  25
GLY D  91
ALA D  90
SER D  93
 None
 0.77A 5f1aB-4ymwD:
undetectable		 5f1aB-4ymwD:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 8 LEU D  67
ILE D  74
ALA D  29
LEU D  25
 HIS  D 301 ( 4.7A)
None
None
None
 0.63A 5y7pC-4ymwD:
undetectable		 5y7pC-4ymwD:
20.94