SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ymx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 6 VAL A 218
VAL A 131
VAL A 151
ILE A 215
 None
 0.98A 3mssD-4ymxA:
undetectable		 3mssD-4ymxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 10 GLN A 128
SER A 157
ASP A  66
ARG A 113
GLU A  51
 None
ARG  A 301 ( 4.7A)
None
ARG  A 301 (-2.9A)
ARG  A 301 (-3.9A)
 1.40A 4fevA-4ymxA:
undetectable		 4fevA-4ymxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A 104
THR A  43
ASP A  66
THR A 195
ARG A 113
 None
None
None
None
ARG  A 301 (-2.9A)
 1.38A 4i41A-4ymxA:
undetectable		 4i41A-4ymxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 6 LYS A 170
LEU A 172
THR A 148
SER A 157
 None
None
None
ARG  A 301 ( 4.7A)
 0.93A 4pwjA-4ymxA:
undetectable		 4pwjA-4ymxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 122
PRO A 109
THR A 108
SER A 157
GLY A 154
 None
None
ARG  A 301 (-4.1A)
ARG  A 301 ( 4.7A)
None
 1.38A 4q15A-4ymxA:
2.9		 4q15A-4ymxA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 122
PRO A 109
THR A 108
SER A 157
GLY A 154
 None
None
ARG  A 301 (-4.1A)
ARG  A 301 ( 4.7A)
None
 1.36A 4q15B-4ymxA:
undetectable		 4q15B-4ymxA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4ymx ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Caldanaerobacter
subterraneus) 		5 / 12 VAL A 237
ASN A 238
ILE A 241
LYS A 245
VAL A 224
 None
 0.70A 5j2tC-4ymxA:
undetectable		 5j2tC-4ymxA:
21.12