SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LW0_A_NVPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	4yn0	AMYLOID BETA A4 PROTEIN (Mus musculus)	5 / 10	LEU B 419 VAL B 479 TYR B 474 LEU B 470 TYR B 401	None	1.40A	1lw0A-4yn0B: undetectable	1lw0A-4yn0B: 17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LWC_A_NVPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	4yn0	AMYLOID BETA A4 PROTEIN (Mus musculus)	5 / 11	LEU B 419 VAL B 479 TYR B 474 LEU B 470 TYR B 401	None	1.42A	1lwcA-4yn0B: undetectable	1lwcA-4yn0B: 17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_A_VDYA1002_1 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	4yn0	AMYLOID BETA A4 PROTEIN (Mus musculus)	4 / 4	ILE B 462 LEU B 459 VAL B 455 ALA B 449	None	0.97A	1mz9A-4yn0B: 3.3	1mz9A-4yn0B: 10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HND_A_NVPA999_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	4yn0	AMYLOID BETA A4 PROTEIN (Mus musculus)	5 / 10	LEU B 419 VAL B 479 TYR B 474 LEU B 470 TYR B 401	None	1.46A	2hndA-4yn0B: 2.5	2hndA-4yn0B: 17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HNY_A_NVPA999_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	4yn0	AMYLOID BETA A4 PROTEIN (Mus musculus)	5 / 10	LEU B 419 VAL B 479 TYR B 474 LEU B 470 TYR B 401	None	1.43A	2hnyA-4yn0B: undetectable	2hnyA-4yn0B: 17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PS9_A_SAMA670_1 (TRNA 5-METHYLAMINOMETHYL- 2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC)	4yn0	TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21 (Mus musculus)	4 / 6	GLY A 52 THR A 53 LEU A 50 GLU A 100	None	0.98A	3ps9A-4yn0A: undetectable	3ps9A-4yn0A: 14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZT_A_SAMA1472_1 (METHYLTRANSFERASE WBDD)	4yn0	AMYLOID BETA A4 PROTEIN (Mus musculus)	3 / 3	GLN B 492 ASP B 485 GLN B 484	None	0.91A	4aztA-4yn0B: undetectable	4aztA-4yn0B: 18.10

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LW0_A_NVPA999_1","HIV-1 REVERSE TRANSCRIPTASE","4yn0","AMYLOID BETA A4 PROTEIN","Mus musculus",5,"LEU B 419;VAL B 479;TYR B 474;LEU B 470;TYR B 401","None","1.40A","1lw0A-4yn0B:undetectable","1lw0A-4yn0B:17.92"],["1LWC_A_NVPA999_1","HIV-1 REVERSE TRANSCRIPTASE","4yn0","AMYLOID BETA A4 PROTEIN","Mus musculus",5,"LEU B 419;VAL B 479;TYR B 474;LEU B 470;TYR B 401","None","1.42A","1lwcA-4yn0B:undetectable","1lwcA-4yn0B:17.92"],["1MZ9_A_VDYA1002_1","CARTILAGE OLIGOMERIC MATRIX PROTEIN","4yn0","AMYLOID BETA A4 PROTEIN","Mus musculus",4,"ILE B 462;LEU B 459;VAL B 455;ALA B 449","None","0.97A","1mz9A-4yn0B:3.3","1mz9A-4yn0B:10.62"],["2HND_A_NVPA999_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","4yn0","AMYLOID BETA A4 PROTEIN","Mus musculus",5,"LEU B 419;VAL B 479;TYR B 474;LEU B 470;TYR B 401","None","1.46A","2hndA-4yn0B:2.5","2hndA-4yn0B:17.88"],["2HNY_A_NVPA999_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","4yn0","AMYLOID BETA A4 PROTEIN","Mus musculus",5,"LEU B 419;VAL B 479;TYR B 474;LEU B 470;TYR B 401","None","1.43A","2hnyA-4yn0B:undetectable","2hnyA-4yn0B:17.88"],["3PS9_A_SAMA670_1","TRNA 5-METHYLAMINOMETHYL-2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC","4yn0","TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21","Mus musculus",4,"GLY A  52;THR A  53;LEU A  50;GLU A 100","None","0.98A","3ps9A-4yn0A:undetectable","3ps9A-4yn0A:14.35"],["4AZT_A_SAMA1472_1","METHYLTRANSFERASE WBDD","4yn0","AMYLOID BETA A4 PROTEIN","Mus musculus",3,"GLN B 492;ASP B 485;GLN B 484","None","0.91A","4aztA-4yn0B:undetectable","4aztA-4yn0B:18.10"]]