SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yn2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4yn2 FUSOLIN
(unidentified
entomopoxvirus) 		4 / 5 LEU A  45
ASP A  42
GLY A  25
ALA A  54
 None
 0.94A 2aohA-4yn2A:
undetectable		 2aohA-4yn2A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4yn2 FUSOLIN
(unidentified
entomopoxvirus) 		5 / 12 HIS A   1
GLY A   2
VAL A 218
GLY A 221
PHE A 103
 ZN  A 404 (-3.0A)
None
None
None
None
 1.03A 3keeB-4yn2A:
undetectable		 3keeB-4yn2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4yn2 FUSOLIN
(unidentified
entomopoxvirus) 		3 / 3 PHE A 136
TYR A 223
LEU A 132
 None
 0.78A 3keeB-4yn2A:
undetectable		 3keeB-4yn2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 4yn2 FUSOLIN
(unidentified
entomopoxvirus) 		5 / 12 HIS A   1
GLY A   2
VAL A 218
GLY A 221
PHE A 103
 ZN  A 404 (-3.0A)
None
None
None
None
 1.00A 3keeC-4yn2A:
undetectable		 3keeC-4yn2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4yn2 FUSOLIN
(unidentified
entomopoxvirus) 		4 / 4 PHE A 136
TYR A 223
ARG A 202
LEU A 132
 None
 0.93A 3sueA-4yn2A:
undetectable		 3sueA-4yn2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4yn2 FUSOLIN
(unidentified
entomopoxvirus) 		3 / 3 PHE A 136
TYR A 223
LEU A 132
 None
 0.74A 3sueB-4yn2A:
undetectable		 3sueB-4yn2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4yn2 FUSOLIN
(unidentified
entomopoxvirus) 		3 / 3 ASP A  42
LYS A  43
ASP A  46
 None
 0.69A 4a7tA-4yn2A:
2.6		 4a7tA-4yn2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4yn2 FUSOLIN
(unidentified
entomopoxvirus) 		4 / 5 THR A 139
ALA A 140
TYR A 193
HIS A   1
 None
ZN  A 404 ( 4.3A)
None
ZN  A 404 (-3.0A)
 1.26A 5ecmA-4yn2A:
undetectable		 5ecmA-4yn2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4yn2 FUSOLIN
(unidentified
entomopoxvirus) 		4 / 8 GLY A 221
GLN A 213
PHE A 136
TYR A 193
 None
 0.80A 6eqpA-4yn2A:
undetectable		 6eqpA-4yn2A:
13.24