SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 8 THR A  78
GLY A 381
LEU A 383
ARG A 377
GLY A 385
 None
 1.34A 1d0vA-4yn5A:
2.7		 1d0vA-4yn5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 9 THR A  78
GLY A 381
LEU A 383
ARG A 377
GLY A 385
 None
 1.32A 1jhyA-4yn5A:
2.7		 1jhyA-4yn5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 9 THR A  78
GLY A 381
LEU A 383
ARG A 377
GLY A 385
 None
 1.33A 1l4nA-4yn5A:
undetectable		 1l4nA-4yn5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 12 ASP A 275
LEU A 269
LEU A 265
MET A 307
TYR A 268
 None
 1.48A 1p33A-4yn5A:
2.2		 1p33A-4yn5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 12 ASP A 275
LEU A 269
LEU A 265
MET A 307
TYR A 268
 None
 1.42A 1p33B-4yn5A:
2.2		 1p33B-4yn5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 10 ASP A 284
TYR A 231
THR A 322
GLY A 282
ARG A 209
 None
None
None
None
CAC  A 501 ( 4.9A)
 1.45A 1rmtA-4yn5A:
undetectable		 1rmtA-4yn5A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 12 MET A 360
ARG A 356
LEU A 345
ILE A 348
PHE A 404
 None
 1.19A 1y0xX-4yn5A:
undetectable		 1y0xX-4yn5A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		3 / 3 THR A 362
PRO A 375
TYR A 341
 None
 0.88A 2dxrA-4yn5A:
undetectable		 2dxrA-4yn5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 6 ARG A 243
TYR A 253
THR A 238
PRO A 210
 None
 1.40A 2ql8A-4yn5A:
undetectable
2ql8B-4yn5A:
undetectable		 2ql8A-4yn5A:
16.02
2ql8B-4yn5A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 8 ASN A 153
PHE A 154
VAL A 167
PHE A 211
 None
 1.07A 2wekB-4yn5A:
undetectable		 2wekB-4yn5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		3 / 3 LEU A 413
TRP A 411
GLY A 143
 None
 0.64A 3l35A-4yn5A:
undetectable
3l35H-4yn5A:
undetectable		 3l35A-4yn5A:
7.87
3l35H-4yn5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		3 / 3 LEU A 413
TRP A 411
GLY A 143
 None
 0.71A 3l35B-4yn5A:
undetectable
3l35K-4yn5A:
undetectable		 3l35B-4yn5A:
7.87
3l35K-4yn5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 6 GLN A 361
HIS A 150
ARG A 209
HIS A 212
 None
CAC  A 501 (-3.8A)
CAC  A 501 ( 4.9A)
CAC  A 501 (-3.8A)
 1.25A 3nvcA-4yn5A:
undetectable		 3nvcA-4yn5A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		3 / 3 HIS A 150
SER A 110
GLU A 115
 CAC  A 501 (-3.8A)
None
None
 0.90A 3s8pA-4yn5A:
undetectable		 3s8pA-4yn5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 7 PRO A 101
GLY A 143
ALA A 102
PHE A 104
 None
 0.95A 3tehB-4yn5A:
undetectable		 3tehB-4yn5A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 7 TYR A 341
LEU A 389
ASN A 332
TYR A 368
 None
 1.37A 4f8yC-4yn5A:
undetectable
4f8yD-4yn5A:
1.1		 4f8yC-4yn5A:
17.87
4f8yD-4yn5A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 8 GLY A 367
GLY A  76
GLU A  75
LEU A  79
 None
 0.90A 4fgzB-4yn5A:
undetectable		 4fgzB-4yn5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 8 LEU A 185
LEU A 172
TYR A 235
MET A 149
 None
 1.11A 5hbsA-4yn5A:
undetectable		 5hbsA-4yn5A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		3 / 3 GLY A 384
ASP A 378
ASN A  95
 None
 0.51A 5jglA-4yn5A:
undetectable		 5jglA-4yn5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 12 GLY A 300
ASP A 284
THR A 322
ALA A 306
LEU A 305
 None
 0.85A 5kocA-4yn5A:
undetectable		 5kocA-4yn5A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 12 ARG A 209
GLN A 285
LEU A 283
LEU A 301
ILE A 348
 CAC  A 501 ( 4.9A)
None
None
None
None
 1.10A 5uahC-4yn5A:
undetectable		 5uahC-4yn5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 12 ALA A  72
VAL A 374
PHE A 104
LEU A 405
ARG A  85
 None
 1.19A 5w7pA-4yn5A:
undetectable		 5w7pA-4yn5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 5 ALA A 358
SER A  61
GLY A  62
TYR A 401
 None
 1.22A 5yodB-4yn5A:
undetectable		 5yodB-4yn5A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		5 / 12 ILE A 280
VAL A  42
LEU A  57
THR A  50
LEU A  53
 None
 1.24A 6b54A-4yn5A:
undetectable		 6b54A-4yn5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 7 ASP A 186
ALA A 190
LYS A 246
LEU A 242
 None
 0.93A 6ci6A-4yn5A:
undetectable		 6ci6A-4yn5A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		4 / 8 GLY A  68
GLN A 361
PHE A 396
TYR A 341
 None
 1.16A 6eqpA-4yn5A:
undetectable		 6eqpA-4yn5A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE
(Bacillus
sp.
JAMB750) 		3 / 3 TRP A 220
ILE A 171
GLU A 230
 None
 0.72A 6hcxA-4yn5A:
undetectable		 6hcxA-4yn5A:
13.41