SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yn8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AW1_A_COXA264_1 (CARBONIC ANHYDRASE II)	4yn8	RESPONSE REGULATOR CHRA (Corynebacterium diphtheriae)	5 / 12	ILE A 44 VAL A 47 LEU A 65 VAL A 73 LEU A 61	None	0.98A	2aw1A-4yn8A: undetectable	2aw1A-4yn8A: 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UBE_A_2FAA401_2 (ADENOSINE KINASE)	4yn8	RESPONSE REGULATOR CHRA (Corynebacterium diphtheriae)	4 / 4	ALA A 105 VAL A 110 GLY A 95 THR A 119	None	0.93A	4ubeA-4yn8A: 4.9	4ubeA-4yn8A: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XJ7_D_ADND303_1 (5'/3'-NUCLEOTIDASE SURE)	4yn8	RESPONSE REGULATOR CHRA (Corynebacterium diphtheriae)	5 / 10	GLY A 36 ASP A 9 SER A 34 ALA A 83 ILE A 59	None MG A 204 (-4.0A) SO4 A 201 (-4.2A) SO4 A 200 (-3.5A) None	1.07A	4xj7C-4yn8A: 4.7 4xj7D-4yn8A: 4.7	4xj7C-4yn8A: 26.42 4xj7D-4yn8A: 26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C0O_H_SAMH301_1 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE TRMI)	4yn8	RESPONSE REGULATOR CHRA (Corynebacterium diphtheriae)	4 / 5	THR A 56 GLY A 58 HIS A 10 ASP A 35	None None MG A 204 (-3.5A) None	1.24A	5c0oH-4yn8A: undetectable	5c0oH-4yn8A: 25.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2AW1_A_COXA264_1","CARBONIC ANHYDRASE II","4yn8","RESPONSE REGULATOR CHRA","Corynebacterium diphtheriae",5,"ILE A  44;VAL A  47;LEU A  65;VAL A  73;LEU A  61","None","0.98A","2aw1A-4yn8A:undetectable","2aw1A-4yn8A:24.42"],["4UBE_A_2FAA401_2","ADENOSINE KINASE","4yn8","RESPONSE REGULATOR CHRA","Corynebacterium diphtheriae",4,"ALA A 105;VAL A 110;GLY A  95;THR A 119","None","0.93A","4ubeA-4yn8A:4.9","4ubeA-4yn8A:20.29"],["4XJ7_D_ADND303_1","5'\/3'-NUCLEOTIDASE SURE;5'\/3'-NUCLEOTIDASE SURE","4yn8","RESPONSE REGULATOR CHRA","Corynebacterium diphtheriae",5,"GLY A  36;ASP A   9;SER A  34;ALA A  83;ILE A  59","None; MG A 204 (-4.0A);SO4 A 201 (-4.2A);SO4 A 200 (-3.5A);None","1.07A","4xj7C-4yn8A:4.7;4xj7D-4yn8A:4.7","4xj7C-4yn8A:26.42;4xj7D-4yn8A:26.42"],["5C0O_H_SAMH301_1","TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRMI","4yn8","RESPONSE REGULATOR CHRA","Corynebacterium diphtheriae",4,"THR A  56;GLY A  58;HIS A  10;ASP A  35","None;None; MG A 204 (-3.5A);None","1.24A","5c0oH-4yn8A:undetectable","5c0oH-4yn8A:25.67"]]