SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ync'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		3 / 3 TRP A 316
ALA A 266
VAL A 312
 None
 0.91A 1c4dC-4yncA:
undetectable
1c4dD-4yncA:
undetectable		 1c4dC-4yncA:
3.29
1c4dD-4yncA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 5 GLN A 168
TRP A  89
GLU A 172
LEU A 127
 None
 1.50A 1ulvA-4yncA:
undetectable		 1ulvA-4yncA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 LEU A  27
ILE A  22
VAL A 357
PHE A 284
HIS A 286
 None
 1.37A 2qo4A-4yncA:
undetectable		 2qo4A-4yncA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		3 / 3 GLY A 119
TYR A 134
SER A 136
 None
 0.78A 2xatA-4yncA:
undetectable		 2xatA-4yncA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 7 VAL A 174
LYS A 178
ILE A 181
GLY A 184
 None
 0.80A 3bjwF-4yncA:
undetectable		 3bjwF-4yncA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 7 VAL A 174
LYS A 178
ILE A 181
GLY A 184
 None
 0.86A 3bjwH-4yncA:
undetectable		 3bjwH-4yncA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		6 / 11 VAL A 285
LEU A 242
LEU A 287
VAL A 268
GLY A 270
ALA A 269
 None
 1.35A 3pghB-4yncA:
0.0		 3pghB-4yncA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		6 / 12 VAL A 285
LEU A 242
LEU A 287
VAL A 268
GLY A 270
ALA A 269
 None
 1.35A 3pghC-4yncA:
undetectable		 3pghC-4yncA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		6 / 12 VAL A 285
LEU A 242
LEU A 287
VAL A 268
GLY A 270
ALA A 269
 None
 1.35A 3pghD-4yncA:
undetectable		 3pghD-4yncA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 7 THR A  37
HIS A 191
ASN A 194
TYR A 196
TYR A 375
 4EG  A 402 ( 3.4A)
FMN  A 401 (-3.6A)
4EG  A 402 ( 3.0A)
4EG  A 402 (-3.7A)
FMN  A 401 (-4.9A)
 0.63A 4a3uA-4yncA:
48.7		 4a3uA-4yncA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 7 THR A  37
HIS A 191
ASN A 194
TYR A 196
TYR A 375
 4EG  A 402 ( 3.4A)
FMN  A 401 (-3.6A)
4EG  A 402 ( 3.0A)
4EG  A 402 (-3.7A)
FMN  A 401 (-4.9A)
 0.62A 4a3uB-4yncA:
48.8		 4a3uB-4yncA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 7 THR A  37
HIS A 191
ASN A 194
TYR A 196
 4EG  A 402 ( 3.4A)
FMN  A 401 (-3.6A)
4EG  A 402 ( 3.0A)
4EG  A 402 (-3.7A)
 0.42A 4awuA-4yncA:
49.1		 4awuA-4yncA:
38.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 6 THR A  37
HIS A 191
TYR A 196
TYR A 375
 4EG  A 402 ( 3.4A)
FMN  A 401 (-3.6A)
4EG  A 402 (-3.7A)
FMN  A 401 (-4.9A)
 0.77A 4df2A-4yncA:
58.3		 4df2A-4yncA:
42.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 GLN A  93
ILE A 100
TYR A  57
PRO A  35
ILE A  68
 None
None
None
FMN  A 401 (-3.9A)
None
 1.28A 4drhD-4yncA:
undetectable		 4drhD-4yncA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 VAL A 285
LEU A 242
VAL A 268
GLY A 270
ALA A 269
 None
 1.09A 4otyA-4yncA:
undetectable		 4otyA-4yncA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 11 ALA A  73
VAL A 111
ASP A 186
SER A 180
GLY A 184
 None
 0.84A 4xp4A-4yncA:
undetectable		 4xp4A-4yncA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 ALA A 121
GLY A 119
GLY A  80
ALA A 137
LEU A 198
 None
 0.95A 5c0oG-4yncA:
undetectable		 5c0oG-4yncA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 LEU A 115
GLN A 114
GLY A 241
ASN A 194
VAL A 117
 None
FMN  A 401 (-2.9A)
None
4EG  A 402 ( 3.0A)
None
 1.31A 5d0yA-4yncA:
undetectable		 5d0yA-4yncA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		3 / 3 GLU A  55
TYR A  56
ARG A  60
 None
 0.81A 5uunA-4yncA:
undetectable		 5uunA-4yncA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		3 / 3 GLU A  55
TYR A  56
ARG A  60
 None
 0.83A 5uunB-4yncA:
undetectable		 5uunB-4yncA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		7 / 8 THR A  37
HIS A 191
ASN A 194
TYR A 196
PHE A 250
PRO A 295
TYR A 375
 4EG  A 402 ( 3.4A)
FMN  A 401 (-3.6A)
4EG  A 402 ( 3.0A)
4EG  A 402 (-3.7A)
4EG  A 402 ( 4.6A)
4EG  A 402 ( 4.5A)
FMN  A 401 (-4.9A)
 0.52A 5v4vA-4yncA:
73.8		 5v4vA-4yncA:
79.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		7 / 8 THR A  37
HIS A 191
ASN A 194
TYR A 196
PHE A 250
PRO A 295
TYR A 375
 4EG  A 402 ( 3.4A)
FMN  A 401 (-3.6A)
4EG  A 402 ( 3.0A)
4EG  A 402 (-3.7A)
4EG  A 402 ( 4.6A)
4EG  A 402 ( 4.5A)
FMN  A 401 (-4.9A)
 0.53A 5v4vB-4yncA:
73.8		 5v4vB-4yncA:
79.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 8 GLY A 363
ARG A  63
GLN A  62
ASP A 358
 None
 1.08A 5vlmA-4yncA:
undetectable		 5vlmA-4yncA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 8 ASN A 207
GLN A 200
ASN A 140
TRP A 120
 None
 1.32A 5vunA-4yncA:
undetectable		 5vunA-4yncA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 8 LEU A 244
ILE A 315
ALA A 221
LEU A 225
 None
 0.78A 5y7pC-4yncA:
undetectable		 5y7pC-4yncA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 4 GLY A  81
ARG A 129
ASN A 126
LEU A 127
 None
 1.25A 6b58A-4yncA:
undetectable		 6b58A-4yncA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 6 GLU A 273
ARG A 281
LYS A 317
VAL A 320
 None
 1.47A 6fgdA-4yncA:
undetectable		 6fgdA-4yncA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		5 / 12 ASP A 310
ASN A 309
PHE A 311
PRO A 290
GLY A 324
 CL  A 403 ( 4.0A)
None
None
None
FMN  A 401 (-3.7A)
 1.35A 6gnfA-4yncA:
undetectable		 6gnfA-4yncA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4ync NADPH DEHYDROGENASE
1
(Saccharomyces
pastorianus) 		4 / 6 PRO A 354
ILE A 383
TYR A  56
GLU A  55
 None
 1.02A 6gqiA-4yncA:
undetectable		 6gqiA-4yncA:
21.14